INT98702

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.48
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
amygdala 2
afferent neurons 2
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 99.78 Very High Very High Very High
amygdala 2 99.68 Very High Very High Very High
Morphine 11 99.28 Very High Very High Very High
cannabis 3 99.12 Very High Very High Very High
Opioid receptor 1 5 95.92 Very High Very High Very High
mu opioid receptor 2 95.92 Very High Very High Very High
alcohol 3 94.44 High High
narcan 4 92.80 High High
Antihyperalgesic 2 89.60 High High
Opioid 11 86.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 99.78 Very High Very High Very High
Adhesions 6 94.00 High High
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether protein expressed from this cDNA exhibits the biochemical characteristics expected of the mu 3 receptor, the cDNA clone was expressed in a heterologous system.
Spec (whether) Positive_regulation (expected) of Gene_expression (expected) of mu 3 receptor
1) Confidence 0.31 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12734358 Disease Relevance 0 Pain Relevance 1.03
At 2 and 6 hours, a rebound effect was observed as noted by an increase in mu receptor expression, and at 24 hours mu receptor expression returned to control levels in the SNAP-treated cells.
Positive_regulation (increase) of Gene_expression (expression) of mu receptor
2) Confidence 0.24 Published 2001 Journal Med. Sci. Monit. Section Body Doc Link 11687719 Disease Relevance 0 Pain Relevance 0
Peripheral inflammation causes an increase in mu receptor levels on peripheral terminals of primary afferent neurons.
Positive_regulation (increase) of Gene_expression (levels) of mu receptor in afferent neurons associated with inflammation
3) Confidence 0.08 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054115 Disease Relevance 0.10 Pain Relevance 0.33
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Positive_regulation (increased) of Gene_expression (expression) of mu receptor in amygdala associated with cannabis and amygdala
4) Confidence 0.07 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.83
Also, indolactam V did not induce mu receptor expression, suggesting that morphine acts on U937 cells in a non-specific fashion.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of mu receptor associated with morphine
5) Confidence 0.00 Published 2001 Journal J. Cell. Physiol. Section Abstract Doc Link 11598903 Disease Relevance 0.38 Pain Relevance 0.92

General Comments

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