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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ear1) cellular_component (Ear1) biological_process (Ear1)
nuclease activity (Ear1)
Anatomy Link Frequency
nasal 1
eosinophil 1
Ear1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 9 97.58 Very High Very High Very High
cytokine 24 59.28 Quite High
Inflammation 17 32.80 Quite Low
corticosteroid 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyps 1 75.00 Quite High
Rhinitis 14 68.72 Quite High
Nasal Polyps 4 54.20 Quite High
Asthma 25 52.16 Quite High
Hypersensitivity 16 51.56 Quite High
Apoptosis 77 50.00 Quite Low
INFLAMMATION 16 32.80 Quite Low
Disease 20 16.92 Low Low
Death 22 5.00 Very Low Very Low Very Low
Hypereosinophilic Syndrome 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Topical treatment with capsaicin significantly increased NSAV and very significantly improved subjective and endoscopy scores, but did not significantly alter ECP levels in nasal lavages.
Neg (not) Regulation (alter) of ECP in nasal associated with qutenza
1) Confidence 0.51 Published 2000 Journal Acta Otolaryngol. Section Abstract Doc Link 11603795 Disease Relevance 0.29 Pain Relevance 0.35
In addition, high levels of PU.1 lead to an increase in myeloid differentiation.3 In most cells, PU.1 antagonizes GATA-1 (a zinc finger family member), the latter of which has synergistic activity in regulating eosinophil lineage specification and eosinophil granule protein transcription.4 The interferon consensus sequence binding protein (ICSBP) is also a key transcription factor for eosinophils and is demonstrated by a loss of eosinophils in ICSBP-deficient mice.5 Of these transcription factors, GATA-1 is clearly the most important for eosinophil lineage specification, based on loss of the eosinophil lineage in mice harboring a targeted deletion of the high affinity GATA-binding site in the GATA-1 promoter,6 and based on eosinophil differentiation experiments in vitro.7
Regulation (regulating) of eosinophil granule protein in eosinophil
2) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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