INT98782

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 70
Total Number 73
Disease Relevance 36.43
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Anatomy Link Frequency
nucleus 4
brain 3
amacrine cells 2
neuronal 1
levator ani 1
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 157 99.18 Very High Very High Very High
Glutamate 35 98.04 Very High Very High Very High
antagonist 74 94.24 High High
cINOD 100 93.16 High High
Neuropathic pain 2 85.72 High High
Inflammation 51 82.64 Quite High
Hippocampus 21 80.56 Quite High
COX-2 inhibitor 7 80.52 Quite High
Pain 2 76.84 Quite High
Migraine 4 76.64 Quite High
Disease Link Frequency Relevance Heat
Renal Cancer 31 100.00 Very High Very High Very High
Cancer 2916 99.96 Very High Very High Very High
Leukemia 56 99.84 Very High Very High Very High
Carcinoma 220 99.82 Very High Very High Very High
Apoptosis 593 99.74 Very High Very High Very High
Breast Cancer 622 99.56 Very High Very High Very High
Lymphatic System Cancer 244 99.50 Very High Very High Very High
Death 106 99.44 Very High Very High Very High
Aging 10 98.64 Very High Very High Very High
Toxicity 62 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.
Gene_expression (expression) of p27Kip1
1) Confidence 0.75 Published 2001 Journal FASEB J. Section Abstract Doc Link 11606477 Disease Relevance 0.70 Pain Relevance 0.20
The expression of p27 protein was detected exclusively in the cytoplasm in five of the six positive cases (90%) while a mixture of nuclear and cytoplasmic protein staining was observed in the last case (Figure 1E).
Gene_expression (expression) of p27
2) Confidence 0.64 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.69 Pain Relevance 0
p27 expression
Gene_expression (expression) of p27
3) Confidence 0.64 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.61 Pain Relevance 0
To improve our understanding of the biology of CDC and to explore the possibility that different genes may be involved in the etiology and prognosis of this neoplasm, we analyzed by immunohistochemistry eleven cases of CDC for the expression of five genes (Fez1, Fhit, p53, p27, and bcl2) often involved in the development of many common cancers.
Spec (analyzed) Gene_expression (expression) of p27 associated with cancer and carcinoma
4) Confidence 0.50 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.18 Pain Relevance 0
Five of the six remaining cases (90%) showed exclusively cytoplasmic protein expression, where, in the last case, p27 protein was detected in both nucleus and cytoplasm.
Gene_expression (detected) of p27 in nucleus
5) Confidence 0.50 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.68 Pain Relevance 0
Here, we have reported the results of our immunohistochemical analysis of the expression of five genes (FEZ1, FHIT, P53, P27kip1, and BCL2) in a relatively large series of CDCs (eleven cases), considering the rarity of this tumor.
Gene_expression (expression) of P27kip1 associated with cancer
6) Confidence 0.50 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.16 Pain Relevance 0
In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2).


Gene_expression (expression) of P27kip1 associated with cancer and renal cancer
7) Confidence 0.50 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.72 Pain Relevance 0
Further, while expression of p19 was variably decreased in lungs from CCSPrtTA/tetO-Sox17 mice maintained on Dox for 2 days, no differences in the expression of p16 or p27 were observed after expression of Sox17 for 1–3 days (data not shown).
Gene_expression (expression) of p27 in lungs
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
p27(KIP1) expression and inhibited cyclin E, cyclin D2 and CDK2 [122].
Gene_expression (expression) of KIP1
9) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.75 Pain Relevance 0
p27(KIP1) expression and inhibited cyclin E, cyclin D2 and CDK2 [122].
Gene_expression (expression) of p27
10) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.75 Pain Relevance 0
In contrast, pCU treated brain sections showed high expression of p27Kip1.
Gene_expression (expression) of p27Kip1 in brain
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.70 Pain Relevance 0
Thus, increased activity of the p27 promoter expressed as luciferase expression with the promoter constructs indicate that the regulation of p27Kip1 protein levels by cathepsin B and uPAR could be, at least partially, explained by the regulation of its promoter activity by increased expression of FOXO3a.
Gene_expression (expressed) of p27
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.11 Pain Relevance 0
Thus, these findings invite the conclusion that the increased p27Kip1 expression with the treatments is due to the increased nuclear expression of FOXO3a, which binds to the -2984 bp region on the p27Kip1 promoter and could be mediated by the low expression of p-AKT.
Gene_expression (expression) of p27Kip1
13) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0.09
Therefore, the G0/G1 arrest induced by the treatments could be due to the combined action of reduced cyclin D1, cyclin D2, and cyclin E-Cdk2 complex formation and increased expression of p27Kip1.
Gene_expression (expression) of p27Kip1
14) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.31 Pain Relevance 0
When probed for the expression of p27Kip1 and Ki67 proteins, mock and SV-treated brain sections showed very little expression of p27Kip1 and increased expression of Ki67.
Gene_expression (expression) of p27Kip1 in brain
15) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.71 Pain Relevance 0
In a separate experiment, we observed decreased expression of p27Kip1 in the nucleus at the 72 hours time point (data not shown).
Gene_expression (expression) of p27Kip1 in nucleus
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.56 Pain Relevance 0.06
Interestingly, we observed high expression of p27Kip1 and very low expression of Ki67 in the tumor sections, indicating the efficiency of treatment both in vitro and in vivo.
Gene_expression (expression) of p27Kip1 associated with cancer
17) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.95 Pain Relevance 0
In particular, the reduced expression of p27Kip1, which is a member of the Kip family of cyclin-dependent kinase (Cdk) inhibitors, has been extensively observed in human cancers, and its low levels are often associated with a worse prognosis [7], [8].
Gene_expression (expression) of p27Kip1 associated with cancer
18) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.09 Pain Relevance 0
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].
Gene_expression (expression) of p27Kip1
19) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
When probed for the expression of p27Kip1 and Ki67 proteins, mock and SV-treated brain sections showed very little expression of p27Kip1 and increased expression of Ki67.
Gene_expression (expression) of p27Kip1 in brain
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.72 Pain Relevance 0

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