INT98784

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.53
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Ccnb1) cytoplasm (Ccnb1) mitosis (Ccnb1)
nucleus (Ccnb1) cytoskeleton (Ccnb1) cell cycle (Ccnb1)
Anatomy Link Frequency
skin 1
cervix 1
Ccnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 94.96 High High
Angina 1 86.76 High High
Inflammation 40 84.08 Quite High
COX-2 inhibitor 5 83.80 Quite High
cINOD 14 71.08 Quite High
cytokine 31 51.60 Quite High
COX2 4 25.00 Low Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 150 98.00 Very High Very High Very High
Skin Cancer 13 94.64 High High
Leukemia 2 94.08 High High
Lymphatic System Cancer 3 93.68 High High
Cancer 152 92.40 High High
Colon Cancer 37 88.52 High High
Cv General 3 Under Development 1 86.76 High High
INFLAMMATION 34 84.08 Quite High
Hepatocellular Cancer 3 83.36 Quite High
Non-small-cell Lung Cancer 13 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
Gene_expression (targets) of Ccnb1
1) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.12 Pain Relevance 0
In Comparison 1 (Fig. 1) on P5 non-fasted mice of the two genotypes, the microarray data showed only seven genes with increased (Ang3, V1re8, Wscd2, Ctnnbl1, Rnf167, Fmo4 and Pot1b), and eight genes with decreased expression (Prpf3, Ccnb1, Actrt1, Gtl28d1, Oflr259, Lrrc39, Fryl and ORF9) in Snord116del pups with fold changes greater than 23% (20.3) and t values >4.
Gene_expression (expression) of Ccnb1
2) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.09 Pain Relevance 0
The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.
Gene_expression (expression) of cyclin B1
3) Confidence 0.34 Published 2001 Journal FASEB J. Section Abstract Doc Link 11606477 Disease Relevance 0.68 Pain Relevance 0.21
Thus, it is likely that the inactivation of p53 function by HPV16 E6 oncoprotein might be responsible for cyclin B1 overexpression in skin.
Gene_expression (overexpression) of cyclin B1 in skin
4) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.39 Pain Relevance 0
In agreement with these observations, a high differential expression of cyclin B1 was consistently found in skin from K14E6 as compared to nontrangenic mice, but we did not see significant modulation of cyclin B1 or other components of the cell cycle control in cervix from K14E6 mice.
Gene_expression (expression) of cyclin B1 in cervix
5) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.57 Pain Relevance 0
The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.
Gene_expression (expression) of cyclin B1
6) Confidence 0.26 Published 2001 Journal FASEB J. Section Abstract Doc Link 11606477 Disease Relevance 0.69 Pain Relevance 0.21
CDK4, proliferating cell nuclear antigen (PCNA) and cyclin B1, were also found
Gene_expression (found) of cyclin B1
7) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.59 Pain Relevance 0.11
Interestingly, in contrast to extracellular Gal-4 addition, Gal-4-blockade had no impact on cyclin B1 expression (Fig. 3D).
Gene_expression (expression) of cyclin B1
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.03
A possible reason for this cell cycle effect is the decrease in the protein levels of cyclins A and B1, which are regulators of S and G2/M phases, respectively.
Gene_expression (levels) of B1
9) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.26 Pain Relevance 0
Expression of cyclins B1, D3 and E and p21, p27, bax, bcl2 and cox-2 was studied immunohistochemically.
Gene_expression (Expression) of cyclins B1
10) Confidence 0.00 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17434727 Disease Relevance 0.62 Pain Relevance 0.07
The mean proliferation index was low and comparable among stent types; cyclins B1 and D1 were expressed in all DES.
Gene_expression (expressed) of cyclins B1
11) Confidence 0.00 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19962471 Disease Relevance 0.52 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox