INT98786

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 8.70
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 35 93.56 High High
COX-2 inhibitor 3 80.92 Quite High
gABA 4 72.08 Quite High
Neurotransmitter 4 71.28 Quite High
agonist 49 53.60 Quite High
antagonist 20 41.28 Quite Low
COX2 1 25.00 Low Low
fibrosis 6 22.56 Low Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 862 98.96 Very High Very High Very High
Apoptosis 203 98.88 Very High Very High Very High
Hepatocellular Cancer 78 98.60 Very High Very High Very High
Breast Cancer 220 97.08 Very High Very High Very High
Glioma 312 95.36 Very High Very High Very High
INFLAMMATION 35 93.32 High High
Infection 24 92.64 High High
Stomach Cancer 37 87.52 High High
Leukemia 12 87.48 High High
Colon Cancer 45 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
1) Confidence 0.67 Published 2001 Journal FASEB J. Section Abstract Doc Link 11606477 Disease Relevance 0.70 Pain Relevance 0.20
Thus, these findings invite the conclusion that the increased p27Kip1 expression with the treatments is due to the increased nuclear expression of FOXO3a, which binds to the -2984 bp region on the p27Kip1 promoter and could be mediated by the low expression of p-AKT.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0.09
Indeed, we found that p27kip1 expression increased with LY294002 treatment.
Positive_regulation (increased) of Gene_expression (expression) of p27kip1
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.13 Pain Relevance 0.05
mol/l of CDIM9 increased p27 expression 2.1-fold and 8-fold in MDA-MB231 cells, respectively (Figure 2a).
Positive_regulation (increased) of Gene_expression (expression) of p27
4) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.23 Pain Relevance 0
Although overexpression of p27Kip1 can induce protection from apoptosis, other studies have reported pro-apoptotic effects where caspases are able to cleave p27Kip1 in a cell type specific manner [9], [61] reported that the inhibition of cytochrome c release might be a possible mechanism of preventing apoptosis with higher p27Kip1 expression in leukemia cells; this indicates that the regulation of the apoptotic process by p27Kip1 might vary with cell transformation status.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p27Kip1 associated with leukemia and apoptosis
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.54 Pain Relevance 0.08
Therefore, the G0/G1 arrest induced by the treatments could be due to the combined action of reduced cyclin D1, cyclin D2, and cyclin E-Cdk2 complex formation and increased expression of p27Kip1.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.31 Pain Relevance 0
We also show that increased expression of p27Kip1 is due to the efficient binding of FOXO3a on its promoter, which was analyzed by the luciferase expression.


Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.28 Pain Relevance 0
Western blot analysis revealed that p27Kip1 expression increased with the treatments while its phosphorylation at Ser10 and Thr187 decreased, thereby indicating the nuclear localization of increased p27Kip1 protein.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.39 Pain Relevance 0
Here, we show that shRNA-mediated downregulation of cathepsin B and uPAR results in G0/G1 arrest, prominent increased expression of p27Kip1 and inhibition of p-Rb.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.29 Pain Relevance 0
The pCU-treated cells showed a further increase in p27Kip1 expression in both the cell lines.
Positive_regulation (increase) of Gene_expression (expression) of p27Kip1
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.08 Pain Relevance 0
RT-PCR and immunoblot analysis of pC- and pU-treated cell lysates showed increased expression of p27Kip1.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.09 Pain Relevance 0
This increased expression of p27Kip1 correlates with decreased expression of p-PI3K, p-AKT, cyclin E, cyclin D1, cyclin D2 and increased expression of FOXO3a protein.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.28 Pain Relevance 0
Immunoblot and immunocyto analysis demonstrated increased expression of p27Kip1 and its nuclear localization with the knockdown of cathepsin B and uPAR.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.40 Pain Relevance 0
These results were further confirmed with the increased expression of p27Kip1 and FOXO3a when treated with Ly294002 (10 ┬ÁM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27Kip1 was used.
Positive_regulation (increased) of Gene_expression (expression) of p27Kip1
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.35 Pain Relevance 0
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Positive_regulation (measure) of Gene_expression (expression) of p27
15) Confidence 0.16 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
Tumor growth inhibition with CDIM9 in vitro and in vivo correlated with increased p27 and caveolin-1 protein expression.
Positive_regulation (increased) of Gene_expression (expression) of p27 associated with cancer
16) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.84 Pain Relevance 0.03
CDIM9 increased p27 expression level in MDA-MB231 cells in a concentration-dependent manner.
Positive_regulation (increased) of Gene_expression (expression) of p27
17) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0
Expression of p27 was moderately induced (2.9-fold) after CDIM9 treatment.


Positive_regulation (induced) of Gene_expression (Expression) of p27
18) Confidence 0.15 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.35 Pain Relevance 0
Therefore, we may infer that G1 to S arrest induced by knocking down CIAPIN1 in HCC cells was at least partly mediated by downregulation of cyclinD1 and upregulation p27 expression.


Positive_regulation (upregulation) of Gene_expression (expression) of p27 associated with hepatocellular cancer
19) Confidence 0.14 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.32 Pain Relevance 0
In addition, VPA induced alterations in the expression of other cell cycle-related proteins, such as p27 and cyclin D1.
Positive_regulation (induced) of Gene_expression (expression) of p27
20) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.59 Pain Relevance 0

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