INT98789

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 54
Total Number 57
Disease Relevance 40.27
Pain Relevance 11.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 8
brain 8
peripheral nervous system 4
cardiomyocyte 2
neurons 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 563 100.00 Very High Very High Very High
Hippocampus 299 100.00 Very High Very High Very High
Abeta 100 100.00 Very High Very High Very High
cINOD 216 99.98 Very High Very High Very High
tetrodotoxin 5 99.84 Very High Very High Very High
Demyelination 4 99.82 Very High Very High Very High
agonist 38 99.72 Very High Very High Very High
Eae 59 99.56 Very High Very High Very High
Nicotine 5 98.18 Very High Very High Very High
IPN 4 92.16 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 2056 100.00 Very High Very High Very High
Alzheimer's Dementia 2027 100.00 Very High Very High Very High
Disease 1923 100.00 Very High Very High Very High
INFLAMMATION 691 100.00 Very High Very High Very High
Cognitive Disorder 511 100.00 Very High Very High Very High
Congenital Anomalies 94 99.92 Very High Very High Very High
Immunization 80 99.92 Very High Very High Very High
Demyelinating Disease 16 99.82 Very High Very High Very High
Toxicity 101 99.48 Very High Very High Very High
Sprains And Strains 65 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(by either inhibiting secretase activity or inhibiting APP expression) may not quickly reverse preexisting pathology, but should effectively halt further deposition of amyloid.
Negative_regulation (inhibiting) of Gene_expression (expression) of APP associated with alzheimer's dementia
1) Confidence 0.58 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.51 Pain Relevance 0
Mice in which APP synthesis was suppressed for as long as 6 mo after the formation of A?
Negative_regulation (suppressed) of Gene_expression (synthesis) of APP
2) Confidence 0.58 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1283364 Disease Relevance 1.36 Pain Relevance 0
We sought to determine whether pioglitazone, a novel anti-inflammatory drug, reduces glia activation, APP expression, and A?
Spec (whether) Negative_regulation (reduces) of Gene_expression (expression) of APP associated with inflammation
3) Confidence 0.57 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 1.24 Pain Relevance 0.39
We show that ibuprofen reduced Abeta brain levels in rats from exogenously infused Abeta in the absence of altered Abeta production.
Negative_regulation (absence) of Gene_expression (production) of Abeta in brain associated with abeta
4) Confidence 0.55 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15688088 Disease Relevance 0.75 Pain Relevance 0.67
Recent data show that in addition to the suppression of inflammatory processes in the brain NSAIDs may decrease the production of Abeta peptides.
Spec (may) Negative_regulation (decrease) of Gene_expression (production) of Abeta in brain associated with inflammation, cinod and abeta
5) Confidence 0.51 Published 2003 Journal Drugs Aging Section Abstract Doc Link 12534311 Disease Relevance 1.35 Pain Relevance 0.86
Following as little as 2 wk of dox treatment, transgenic APP expression was reduced by more than 95% compared to pre-dox levels.
Negative_regulation (reduced) of Gene_expression (expression) of APP associated with targeted disruption
6) Confidence 0.51 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.65 Pain Relevance 0.04
We show that doxycycline administration inhibits transgenic APP expression by greater than 95% and reduces A?
Negative_regulation (inhibits) of Gene_expression (expression) of APP associated with targeted disruption
7) Confidence 0.51 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1283364 Disease Relevance 1.29 Pain Relevance 0
levels by limiting its production from the precursor protein APP.
Negative_regulation (limiting) of Gene_expression (production) of APP
8) Confidence 0.51 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.68 Pain Relevance 0
In preclinical studies, Ginkgo biloba extract (EGB 761) blocked the production of amyloid beta peptide and amyloid precursor protein in aged rodents [191].
Negative_regulation (blocked) of Gene_expression (production) of amyloid precursor protein associated with alzheimer's dementia
9) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.17 Pain Relevance 0.26
However, levels of amyloid precursor (APP) in the membrane fraction were not reduced.
Neg (not) Negative_regulation (reduced) of Gene_expression (levels) of APP associated with alzheimer's dementia
10) Confidence 0.43 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11606625 Disease Relevance 0.84 Pain Relevance 0.49
The translational inhibitor anisomycin blocked DHPG-mediated synthesis of APP, as did the specific mGluR5 inhibitor MPEP (Figure 3C and 3D).
Negative_regulation (blocked) of Gene_expression (synthesis) of APP
11) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.49 Pain Relevance 0
It allows the internalization of several ligands such as ApoE, APP (with the Kunitz inhibitor) and ?
Negative_regulation (inhibitor) of Gene_expression (with) of APP
12) Confidence 0.43 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.82 Pain Relevance 0.09
Transfecting the APP gene induces an overproduction of the protein, and APP overproduction may be sufficient to increase A?
Negative_regulation (sufficient) of Gene_expression (overproduction) of APP
13) Confidence 0.43 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.49 Pain Relevance 0
The dysregulation in the metabolism of beta-amyloid precursor protein and consequent deposition of amyloid-beta (Abeta) has been envisaged as crucial for the development of neurodegeneration in Alzheimer's disease (AD).
Negative_regulation (deposition) of Gene_expression (metabolism) of beta-amyloid precursor protein associated with alzheimer's dementia, disease and abeta
14) Confidence 0.42 Published 2003 Journal Drugs Aging Section Abstract Doc Link 12534311 Disease Relevance 0.64 Pain Relevance 0.14
These data suggest that APP mRNA is translationally repressed by FMRP in unstimulated WT SNs. mGluR activation rapidly derepresses APP synthesis as shown for FMRP and PSD-95 [21,22].
Negative_regulation (derepresses) of Gene_expression (synthesis) of APP
15) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.78 Pain Relevance 0
are present, whereas in old APP/PS1 mice (15-month-old) neurodegeneration in the hippocampus becomes clear, and cognitive impairment and A?
Negative_regulation (old) of Gene_expression (neurodegeneration) of APP in hippocampus associated with cognitive disorder and hippocampus
16) Confidence 0.42 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.99 Pain Relevance 0.05
Although the link between reduced phospholamban expression and altered cardiac contractile function in APP/PS1 hearts is unclear, reduced phospholamban levels may trigger altered intracellular Ca2+ homeostasis en route to affect cardiomyocyte contractile function [18].
Negative_regulation (reduced) of Gene_expression (expression) of APP/PS1 in cardiomyocyte
17) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.30 Pain Relevance 0.03
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has been found beneficial for AD and several reports suggest that NSAIDs reduce the generation of Abeta, especially the more amyloidogenic form Abeta42.
Negative_regulation (reduce) of Gene_expression (generation) of Abeta associated with inflammation, cinod, disease and abeta
18) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19659691 Disease Relevance 0.88 Pain Relevance 0.84
As to the notion that sustained inflammation is detrimental, a recent study reports that chronic overexpression of IL-1( in the hippocampus of APP/PS1 transgenic animals results in decreased plaque burden and insoluble A?
Negative_regulation (hippocampus) of Gene_expression (animals) of APP in plaque associated with targeted disruption, inflammation and hippocampus
19) Confidence 0.38 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2998033 Disease Relevance 0.72 Pain Relevance 0.16
APP/PS1 double Tg mice exhibit accelerated A?
Negative_regulation (/) of Gene_expression (exhibit) of APP associated with targeted disruption
20) Confidence 0.38 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.97 Pain Relevance 0.04

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