INT98795

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.20
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
bladder 4
dorsal root ganglia 2
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 11 99.76 Very High Very High Very High
epidural 1 99.38 Very High Very High Very High
allodynia 2 96.96 Very High Very High Very High
Brush evoked pain 1 92.68 High High
Pain 6 84.56 Quite High
anesthesia 2 78.00 Quite High
tetrodotoxin 4 75.00 Quite High
Visceral pain 2 75.00 Quite High
Spinal cord 2 38.64 Quite Low
Root ganglion neuron 2 26.48 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 96.96 Very High Very High Very High
Nociception 3 96.96 Very High Very High Very High
Injury 4 96.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 75.00 Quite High
Attention Deficit Hyperactivity Disorder 2 58.72 Quite High
Pain 2 53.68 Quite High
Ganglion Cysts 2 26.08 Quite Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the effect of inhibiting the expression of Na(v)1.8 (PN3/SNS) sodium channels by an antisense oligodeoxynucleotide (ODN) on bladder nociceptive responses induced by intravesical acetic acid infusion in rats.
Negative_regulation (inhibiting) of Gene_expression (expression) of PN3 in bladder associated with nociception and sodium channel
1) Confidence 0.57 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11606657 Disease Relevance 0.16 Pain Relevance 0.32
The present study investigated the effect of inhibiting the expression of Na(v)1.8 (PN3/SNS) sodium channels by an antisense oligodeoxynucleotide (ODN) on bladder nociceptive responses induced by intravesical acetic acid infusion in rats.
Negative_regulation (inhibiting) of Gene_expression (expression) of Na(v)1.8 in bladder associated with nociception and sodium channel
2) Confidence 0.41 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11606657 Disease Relevance 0.16 Pain Relevance 0.31
The siRNA, which was delivered to lumbar dorsal root ganglia (DRG) via an indwelling epidural cannula, caused a significant reduction of Na(V)1.8 mRNA expression in lumbar 4 and 5 (L4-L5) DRG neurons and consequently reversed mechanical allodynia in CCI rats.
Negative_regulation (reduction) of Gene_expression (expression) of Na(V)1.8 in dorsal root ganglia associated with allodynia, injury and epidural
3) Confidence 0.41 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.74 Pain Relevance 0.66

General Comments

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