INT988

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Context Info
Confidence 0.50
First Reported 1979
Last Reported 1993
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
thyroid 4
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
tolerance 2 100.00 Very High Very High Very High
Serotonin 5 99.76 Very High Very High Very High
Enkephalin 10 99.52 Very High Very High Very High
substance P 3 99.48 Very High Very High Very High
Neurotransmitter 3 97.12 Very High Very High Very High
Spinal cord 4 89.76 High High
Raphe 2 88.24 High High
Central nervous system 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The microcirculation of thyroid was markedly augmented within 2 min after an intraventricular injection of Thyrotropin-Releasing Hormone (TRH) while Met-Enkephalin (ENK) failed to influence.
Positive_regulation (augmented) of Negative_regulation (injection) of Thyrotropin-Releasing Hormone in thyroid associated with enkephalin
1) Confidence 0.50 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 120247 Disease Relevance 0 Pain Relevance 0.42
The microcirculation of thyroid was markedly augmented within 2 min after an intraventricular injection of Thyrotropin-Releasing Hormone (TRH) while Met-Enkephalin (ENK) failed to influence.
Positive_regulation (augmented) of Negative_regulation (injection) of TRH in thyroid associated with enkephalin
2) Confidence 0.50 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 120247 Disease Relevance 0 Pain Relevance 0.42
Together with the present results, it appears that the inhibitory effect of TRH on morphine tolerance-dependence and abstinence is probably not mediated via central TRH receptors but may be due to its interaction with other neurotransmitter systems.
Neg (not) Spec (probably) Positive_regulation (mediated) of Negative_regulation (effect) of TRH associated with addiction, neurotransmitter, tolerance and morphine
3) Confidence 0.50 Published 1990 Journal Peptides Section Abstract Doc Link 2172939 Disease Relevance 0 Pain Relevance 0.97
Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.
Positive_regulation (increased) of Negative_regulation (levels) of TRH associated with serotonin and substance p
4) Confidence 0.21 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58

General Comments

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