INT98815

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr2) extracellular region (Ucn) Golgi apparatus (Crhr2)
endoplasmic reticulum (Crhr2) plasma membrane (Crhr2) signal transducer activity (Crhr2)
Crhr2 (Mus musculus)
Ucn (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 94.48 High High
qutenza 2 91.04 High High
antagonist 6 88.64 High High
Visceral pain 1 75.00 Quite High
Potency 2 63.60 Quite High
Dorsal horn 1 50.08 Quite High
Pain 4 25.00 Low Low
analgesia 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 8 95.92 Very High Very High Very High
Appetite Loss 1 82.36 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 75.00 Quite High
Nociception 2 25.00 Low Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRF receptor 1 (CRF1) binds CRF and Ucn1 with similar high affinity, but CRF receptor 2 (CRF2) binds Ucn1 with higher affinity than CRF.
CRF2 Binding (binds) of Ucn1
1) Confidence 0.32 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.19 Pain Relevance 0.18
These data indicate that intraperitoneal urocortin-induced decrease in feeding is only partly mediated by CRF-R2, whereas urocortin action to delay gastric emptying of a meal involves primarily CRF-R2.
CRF-R2 Binding (action) of urocortin
2) Confidence 0.31 Published 2001 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 11641109 Disease Relevance 0.08 Pain Relevance 0.27
Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands.
CRF2 Binding (binds) of Ucn
3) Confidence 0.02 Published 2004 Journal Peptides Section Abstract Doc Link 15476940 Disease Relevance 0.16 Pain Relevance 0.11

General Comments

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