INT98817

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.62
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
striatum 1
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
imagery 1 99.92 Very High Very High Very High
aspirin 4 99.00 Very High Very High Very High
Inflammation 4 98.16 Very High Very High Very High
cINOD 7 94.96 High High
antagonist 1 79.84 Quite High
Dopamine 1 71.60 Quite High
Abeta 1 65.96 Quite High
Hippocampus 1 59.04 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 2 99.16 Very High Very High Very High
INFLAMMATION 8 98.16 Very High Very High Very High
Drug Induced Neurotoxicity 4 96.92 Very High Very High Very High
Disease 6 95.76 Very High Very High Very High
Reprotox - General 1 2 94.52 High High
Amyloid Plaque 1 92.64 High High
Targeted Disruption 1 82.76 Quite High
Alzheimer's Dementia 1 66.52 Quite High
Fever 1 34.48 Quite Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice.
Regulation (effects) of PPARgamma associated with agonist and imagery
1) Confidence 0.26 Published 2009 Journal Exp. Neurol. Section Title Doc Link 19320004 Disease Relevance 0.81 Pain Relevance 0.30
We examined changes in nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma) in the striatum in methamphetamine (METH)-induced dopaminergic neurotoxicity, and also examined effects of treatment with drugs possessing PPAR gamma agonistic properties.
Spec (examined) Regulation (changes) of nuclear peroxisome proliferator-activated receptor gamma in striatum associated with drug induced neurotoxicity
2) Confidence 0.15 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 18946735 Disease Relevance 0.23 Pain Relevance 0.09
In addition, these PPARgamma agonists modulate a number of antiproliferative and proapoptotic responses, including induction of p27, activating transcription factor 3, and nonsteroidal anti-inflammatory drug-activated gene-1 and down-regulation of cyclin D1 and caveolin-1.
Regulation (modulate) of PPARgamma associated with inflammation, cinod and agonist
3) Confidence 0.08 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17093136 Disease Relevance 0.44 Pain Relevance 0.23
In contrast, indomethacin was able to activate PPARgamma, which was not affected by sodium salicylate or aspirin.
Neg (not) Regulation (affected) of PPARgamma associated with aspirin
4) Confidence 0.03 Published 2001 Journal FASEB J. Section Abstract Doc Link 11641233 Disease Relevance 0.14 Pain Relevance 0.40

General Comments

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