INT98835

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 2.47
Pain Relevance 8.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
brainstem 4
NS20Y 4
poly 2
HL-60 2
proximal 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 273 100.00 Very High Very High Very High
opioid receptor 100 100.00 Very High Very High Very High
Opioid 20 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Inflammation 18 99.98 Very High Very High Very High
Potency 4 98.52 Very High Very High Very High
Morphine 31 96.64 Very High Very High Very High
Analgesic 13 95.88 Very High Very High Very High
Hippocampus 4 94.76 High High
long-term potentiation 4 93.60 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 10 100.00 Very High Very High Very High
INFLAMMATION 14 99.98 Very High Very High Very High
Aids-related Complex 3 92.96 High High
Leukemia 2 92.32 High High
Cv Unclassified Under Development 5 89.32 High High
Toxicity 1 88.04 High High
Repression 39 88.00 High High
Neuroblastoma 13 82.40 Quite High
Contagious Ecthyma 14 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the PU.1 gene is disrupted as in PU.1 knock-out mice and using small interfering RNA-based strategy in RAW264.7 cells, the transcription of the endogenous target MOR gene is increased significantly.
Positive_regulation (When) of Transcription (transcription) of MOR gene associated with targeted disruption and opioid receptor
1) Confidence 0.65 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0.27 Pain Relevance 0.65
When PARP-1 was disrupted in NS20Y cells using siRNA, transcription of the endogenous target MOR gene increased significantly.
Positive_regulation (increased) of Transcription (transcription) of MOR gene in NS20Y associated with mu opioid receptor
2) Confidence 0.59 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.64
Under the ad libitum feeding, mRNA levels of mu-opioid receptor and its binding capacity in mouse brainstem increased around the early dark phase, following the 24-h variation in circulating glucocorticoid levels.
Positive_regulation (increased) of Transcription (levels) of mu-opioid receptor in brainstem associated with medulla and opioid receptor
3) Confidence 0.50 Published 2006 Journal J. Pharmacol. Sci. Section Abstract Doc Link 16682786 Disease Relevance 0 Pain Relevance 0.85
Significant time-dependent variations in the mRNA levels of the mu-opioid receptor and its binding capacity were observed in mouse brainstem.
Positive_regulation (variations) of Transcription (levels) of mu-opioid receptor in brainstem associated with medulla and opioid receptor
4) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109741 Disease Relevance 0.09 Pain Relevance 0.83
The proximal promoter initiates Oprm1 transcription from four major transcription initiation sites located in a region ranging from 291 to 268 bp upstream of the translation start site.
Positive_regulation (initiates) of Transcription (transcription) of Oprm1 in proximal
5) Confidence 0.49 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0.06 Pain Relevance 0.28
The distal promoter initiates Oprm1 transcription from a single initiation site located 794 bp upstream of the translation start site.
Positive_regulation (initiates) of Transcription (transcription) of Oprm1
6) Confidence 0.49 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0.06 Pain Relevance 0.42
Inflammation enhances mu-opioid receptor transcription and expression in mice intestine.
Positive_regulation (enhances) of Transcription (transcription) of mu-opioid receptor in intestine associated with inflammation and opioid receptor
7) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11641416 Disease Relevance 0.43 Pain Relevance 0.59
Our results show that intestinal inflammation enhances the transcription and translation of mu-OR mRNA, thus explaining the increased potency of mu-opioids during inflammation.
Positive_regulation (enhances) of Transcription (transcription) of mu-OR associated with inflammation, opioid and potency
8) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641416 Disease Relevance 0.59 Pain Relevance 0.63
We previously reported that the 34-bp cis-acting element of the mouse micro opioid receptor (MOR) gene represses transcription of the MOR gene from the distal promoter.
Positive_regulation (represses) of Transcription (transcription) of MOR gene associated with opioid receptor
9) Confidence 0.47 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0 Pain Relevance 0.41
Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence.
Positive_regulation (dependent) of Transcription (transcription) of MOR in poly associated with mu opioid receptor
10) Confidence 0.45 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.52
We found that the presence of the uORF region suppressed translation without changing MOR transcription levels.
Neg (without) Positive_regulation (changing) of Transcription (transcription) of MOR associated with mu opioid receptor
11) Confidence 0.45 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0.36
When the PU.1 gene is disrupted as in PU.1 knock-out mice and using small interfering RNA-based strategy in RAW264.7 cells, the transcription of the endogenous target MOR gene is increased significantly.
Positive_regulation (increased) of Transcription (transcription) of MOR gene associated with targeted disruption and opioid receptor
12) Confidence 0.44 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0.27 Pain Relevance 0.62
Mithramycin A up-regulates the endogenous MOR transcription
Positive_regulation (endogenous) of Transcription (transcription) of MOR associated with mu opioid receptor
13) Confidence 0.37 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.22
As shown in Figure 1B and D, RT–PCR and real-time RT–PCR revealed that the mRNA levels of the MOR were increased by mithramycin A treatment in a dose-dependent manner in the NRSF positive NS20Y cells.
Positive_regulation (increased) of Transcription (levels) of MOR in NS20Y associated with mu opioid receptor
14) Confidence 0.35 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.33
Repetitive high-frequency stimulation of cortico-hippocampal perforant path afferents induced strong MOR mRNA expression throughout the granular layer.
Positive_regulation (induced) of Transcription (expression) of MOR associated with opioid receptor
15) Confidence 0.23 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176345 Disease Relevance 0.54 Pain Relevance 0.94
In this study, following TPA treatment, there was a significant increase in mu opioid peptide receptor (MOPR) mRNA levels in the differentiated HL-60 cells as measured by quantitative-competitive RT-PCR (QC-RT-PCR) and real-time RT-PCR.
Positive_regulation (increase) of Transcription (levels) of mu opioid peptide receptor in HL-60 associated with opioid
16) Confidence 0.02 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16782547 Disease Relevance 0.17 Pain Relevance 0.36

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