INT98836

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.04
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 11 99.50 Very High Very High Very High
Paracetamol 12 99.18 Very High Very High Very High
allodynia 1 99.00 Very High Very High Very High
Thermal hyperalgesia 1 98.50 Very High Very High Very High
Analgesic 1 94.96 High High
cva 26 92.12 High High
Spinal cord 5 89.36 High High
Sciatic nerve 3 87.00 High High
Dorsal horn 2 84.20 Quite High
Neuropathic pain 4 78.80 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 99.64 Very High Very High Very High
Injury 24 99.50 Very High Very High Very High
Neuropathic Pain 5 99.00 Very High Very High Very High
Hyperalgesia 1 98.50 Very High Very High Very High
Apoptosis 301 96.64 Very High Very High Very High
Death 86 94.08 High High
Overdose 1 93.96 High High
Hemorrhage 26 92.12 High High
Targeted Disruption 13 88.16 High High
Neurodegenerative Disease 48 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9.
Transcription (levels) of bax associated with allodynia, eae and thermal hyperalgesia
1) Confidence 0.69 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.41 Pain Relevance 1.13
A low level of GFP-BAX was detected in cells treated with 0 ng/ml DOX, suggesting basal transcription from the pTRE-GFP-BAX vector when co-transfected with pTetON.
Transcription (transcription) of GFP-BAX
2) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.44 Pain Relevance 0
To investigate mitochondrial alterations associated with APAP-induced hepatotoxicity, the subcellular distribution of proapoptotic BAX was determined.
Transcription (distribution) of BAX associated with paracetamol and hepatotoxicity
3) Confidence 0.54 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641418 Disease Relevance 0.53 Pain Relevance 0.66
First, a reduction of nestin immunostaining was observed following Bax over-expression (Figures 2A & 2B; group effect: F3,11?
Transcription (observed) of Bax
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.36 Pain Relevance 0
Furthermore, protein data of inversely expressed Bax and Bcl-2 protein expression were confirmed by additional analysis of Bax and Bcl-2 mRNA expression using real-time PCR (data not shown).
Transcription (expression) of Bax
5) Confidence 0.48 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 0.69 Pain Relevance 0.15
In the revised model, the concentration of BAX is not a critical component of the ability of a cell to adequately neutralize anti-apoptotic BCL2 proteins.
Transcription (concentration) of BAX associated with apoptosis
6) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 1.03 Pain Relevance 0.03
A low level of GFP-BAX was detected in cells treated with 0 ng/ml DOX, suggesting basal transcription from the pTRE-GFP-BAX vector when co-transfected with pTetON.
Transcription (transcription) of pTRE-GFP-BAX
7) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.44 Pain Relevance 0
Bak and Bax mRNA expression was amplified using 35 cycles of 94°C for 30 sec, 60°C for 30 sec, and 72°C for 30 sec.
Transcription (expression) of Bax
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.14 Pain Relevance 0

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