INT98837

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 72
Total Number 77
Disease Relevance 63.14
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
MCF-7 3
lung 3
hepatocyte 2
spinal cord 2
SH-SY5Y 1
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 44 100.00 Very High Very High Very High
Spinal cord 170 99.68 Very High Very High Very High
narcan 5 99.60 Very High Very High Very High
aspirin 26 99.40 Very High Very High Very High
Paracetamol 13 98.96 Very High Very High Very High
Morphine 74 98.40 Very High Very High Very High
cva 55 97.84 Very High Very High Very High
Inflammation 536 95.64 Very High Very High Very High
withdrawal 13 91.20 High High
Inflammatory response 74 91.12 High High
Disease Link Frequency Relevance Heat
Apoptosis 2744 100.00 Very High Very High Very High
Death 858 100.00 Very High Very High Very High
Targeted Disruption 202 100.00 Very High Very High Very High
Stress 416 99.50 Very High Very High Very High
Ureteral Obstruction 84 99.32 Very High Very High Very High
Spinal Cord Injury 244 99.02 Very High Very High Very High
Hemorrhagic Shock 102 99.00 Very High Very High Very High
Cancer 1037 98.92 Very High Very High Very High
Infection 175 98.82 Very High Very High Very High
Colon Cancer 145 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of BAX appears to require an independent interaction with a BH3-containing protein [27-29], which allows it to change conformation in the cytoplasm from a globular monomeric protein to one that is able to translocate and insert into the MOM.
Positive_regulation (Activation) of BAX
1) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.78 Pain Relevance 0.07
The activation of BAX during apoptosis is simplistically divided into four basic steps, including initial activation (conformational change) of cytosolic monomers, translocation to the MOM and insertion into this membrane, secondary recruitment of inactivate BAX monomers by MOM-bound BAX molecules, and aggregation of bound and recruited BAX molecules into oligomers that enable the release of cytochrome c.
Positive_regulation (activation) of BAX associated with apoptosis
2) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.63 Pain Relevance 0
Immunoblot analyses indicated increased mitochondrial BAX-beta content very early after APAP or AMAP treatment.
Positive_regulation (increased) of BAX-beta associated with paracetamol
3) Confidence 0.55 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641418 Disease Relevance 0.81 Pain Relevance 0.87
DIM-C-pPhOCH(3) induced caspase-dependent apoptosis in RKO colon cancer cells through decreased mitochondrial membrane potential which is accompanied by increased mitochondrial bax/bcl-2 ratios and release of cytochrome c into the cytosol.
Positive_regulation (increased) of bax in colon associated with colon cancer and apoptosis
4) Confidence 0.49 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 17957723 Disease Relevance 0.65 Pain Relevance 0.12
Bax levels were substantially increased in the lung tissues from zymosan-administered mice (Figure 16A, see densitometric analysis Figure 16A1).
Positive_regulation (increased) of Bax in lung
5) Confidence 0.47 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.51 Pain Relevance 0
A similar dependence for BAX protein was also observed in BAX-deficient HCT116 cells.
Positive_regulation (dependence) of BAX protein associated with addiction
6) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.47 Pain Relevance 0.10
By titrating BAX expression in BAX-deficient HCT116 cells, we demonstrate that the BAX-dependent apoptotic program becomes rapidly saturated with increasing BAX protein.
Positive_regulation (increasing) of BAX protein associated with apoptosis
7) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.63 Pain Relevance 0
The lack of BAX aggregation at sub-saturation levels suggests that the translocation step of BAX activation may be impaired.



Positive_regulation (activation) of BAX
8) Confidence 0.47 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2964639 Disease Relevance 0.46 Pain Relevance 0
The impairment of BAX translocation and/or aggregation in cells expressing sub-lethal levels can be interpreted in several ways, depending on the rate-limiting step for BAX activation.
Positive_regulation (activation) of BAX
9) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.60 Pain Relevance 0.04
Bax levels were substantially increased in the lung tissues from carrageenan-treated mice (Fig. 7Ae, see densitometry analysis 7Ae1).
Positive_regulation (increased) of Bax in lung
10) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.64 Pain Relevance 0.06
Aspirin exposure also resulted in an increase in the half-life of pd1EGFP, a model substrate of proteasome, as well as various intracellular substrates like Bax, IkappaB-alpha, p53, and p27(kip1).
Positive_regulation (increase) of Bax associated with aspirin
11) Confidence 0.45 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16880202 Disease Relevance 0.64 Pain Relevance 0.37
At all events, the ratio of Bax/Bcl-2 was increased during all time points compared with control.
Positive_regulation (increased) of Bax
12) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.63 Pain Relevance 0
A low level of GFP-BAX was detected in cells treated with 0 ng/ml DOX, suggesting basal transcription from the pTRE-GFP-BAX vector when co-transfected with pTetON.
Positive_regulation (detected) of GFP-BAX
13) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.43 Pain Relevance 0
In symptomatic G93A mice, Bax levels are increased and Bcl-2 levels are decreased in the spinal cord as compared to age-matched nontransgenic controls [80].
Positive_regulation (increased) of Bax in spinal cord associated with spinal cord
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.07 Pain Relevance 0.14
Upregulation of Bax/Bcl-2 ratio
Positive_regulation (Upregulation) of Bax
15) Confidence 0.41 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.35 Pain Relevance 0
To generate constructs in the pTRE-Tight vector (Clontech), GFP-BAX was amplified from the pEGFP-C3 plasmid using 5'GCA TGC GAT AGG TAC CAT GGT GAG CAA GGG CGA GG (forward, includes KpnI site) and 5'GTC GCG TCC TAA GCT TTC AGC CCA TCT TCT TCC (reverse, includes HindIII site).
Positive_regulation (amplified) of GFP-BAX in GCT
16) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.31 Pain Relevance 0.06
This facet of the apoptotic activation cascade does not necessarily result in BAX activation, however, and similarly the concentration of BAX likely does not impact the stoichiometric balance between them.
Positive_regulation (activation) of BAX in facet associated with apoptosis
17) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.80 Pain Relevance 0.09
Increased levels of GFP-BAX were unable to stimulate higher levels of cell death.
Positive_regulation (Increased) of GFP-BAX associated with death
18) Confidence 0.41 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2964639 Disease Relevance 0.74 Pain Relevance 0
In contrast in MCF-7 CLU cells, over-expression of secretory clusterin appears to block the effects of TNFalpha on both cell cycle (by blocking the increase in p21) and cell death by preventing the proteolytic activation of Bax (Figure 3 panel B).
Positive_regulation (activation) of Bax in MCF-7 associated with death
19) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.37 Pain Relevance 0
Based on these evidences, we have identified in SCI proapoptotic transcriptional changes, including upregulation of proapoptotic Bax and down regulation of antiapoptotic Bcl-2, by immunohystochemical staining.
Positive_regulation (upregulation) of Bax associated with spinal cord injury and apoptosis
20) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.13 Pain Relevance 0.12

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