INT98849

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.18
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
plasma 1
Adrbk1 (Rattus norvegicus)
Adrbk1 - K220R (1)
Pain Link Frequency Relevance Heat
narcan 12 99.16 Very High Very High Very High
Enkephalin 1 97.20 Very High Very High Very High
agonist 130 89.64 High High
antagonist 20 88.16 High High
adenocard 60 87.12 High High
opioid receptor 2 75.00 Quite High
tetrodotoxin 14 49.48 Quite Low
nMDA receptor 4 29.40 Quite Low
Kinase C 79 25.52 Quite Low
Glutamate 6 21.88 Low Low
Disease Link Frequency Relevance Heat
Necrosis 1 88.32 High High
Cancer 11 87.96 High High
Nash(non-alcoholic Steatohepatitis) 12 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of the dominant-negative mutants GRK2-K220R, arrestin-2(319-418), dynamin I-K44A, rab5A-N133I or rab7-N125I partially prevented the decline in binding of the mutant after naloxone removal.
GRK2 (K220R) Binding (binding) of associated with narcan
1) Confidence 0.36 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641435 Disease Relevance 0 Pain Relevance 0.79
The GRK2 construct also possesses a mutation (D110A) in its regulator of G-protein signalling-like domain, which prevents binding to GTP-bound G?
GRK2 Binding (bound) of
2) Confidence 0.21 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0
treatment prevented GRK2 translocation to and decreased GRK2 association with the plasma membranes of these cells as a consequence of the activation of a sphingomyelinase-dependent pathway.
GRK2 Binding (association) of in plasma
3) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.18 Pain Relevance 0.25

General Comments

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