INT9885

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Context Info
Confidence 0.14
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.28
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
licofelone 10 99.98 Very High Very High Very High
Inflammation 9 98.98 Very High Very High Very High
Inflammatory response 2 93.56 High High
Arthritis 1 93.20 High High
Analgesic 4 85.44 High High
Pain 1 82.56 Quite High
cINOD 1 78.24 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 99.30 Very High Very High Very High
Atherosclerosis 5 99.08 Very High Very High Very High
INFLAMMATION 11 98.98 Very High Very High Very High
Pressure And Volume Under Development 2 94.40 High High
Arthritis 1 93.20 High High
Pain 1 82.56 Quite High
Inflammatory Bowel Disease 1 79.64 Quite High
Granuloma 2 77.92 Quite High
Injury 1 77.28 Quite High
Colitis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings confirm that Me-UCH9 can modulate inflammatory and nociceptive responses in relation to the dual inhibition of COX-2 and 5-LO activities presented by this compound.
Negative_regulation (inhibition) of Gene_expression (presented) of 5-LO associated with nociception and inflammation
1) Confidence 0.14 Published 2007 Journal Life Sci. Section Abstract Doc Link 17490689 Disease Relevance 1.14 Pain Relevance 0.54
Olsalazine treatment decreased all cyclooxygenase and lipoxygenase products to baseline levels.
Negative_regulation (decreased) of Gene_expression (products) of lipoxygenase
2) Confidence 0.03 Published 1992 Journal Agents Actions Section Abstract Doc Link 1442339 Disease Relevance 0.40 Pain Relevance 0.16
Moreover, licofelone inhibited COX-2 and 5-LOX protein expression in vascular lesions.
Negative_regulation (inhibited) of Gene_expression (expression) of 5-LOX associated with licofelone
3) Confidence 0.01 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17015640 Disease Relevance 0.74 Pain Relevance 0.88

General Comments

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