INT98856

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.43
Pain Relevance 7.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
hippocampus 5
NG108-15 2
cerebral cortex 1
locus coeruleus 1
thalamus 1
Adrbk1 (Rattus norvegicus)
Adrbk1 - K220R (2)
Pain Link Frequency Relevance Heat
cerebral cortex 9 99.84 Very High Very High Very High
Morphine 32 99.40 Very High Very High Very High
Hippocampus 10 99.16 Very High Very High Very High
Enkephalin 1 99.04 Very High Very High Very High
Thalamus 6 98.64 Very High Very High Very High
narcan 16 98.24 Very High Very High Very High
Locus ceruleus 4 98.08 Very High Very High Very High
Central grey 4 92.00 High High
agonist 109 91.48 High High
antagonist 18 90.00 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 92.00 High High
Anaplastic Astrocytoma 3 59.76 Quite High
Increased Venous Pressure Under Development 3 7.00 Low Low
Cancer 11 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine treatment resulted in 30-70% down-regulation of GRK2 expression in cerebral cortex, hippocampus, thalamus, and locus coeruleus, opposite to what observed with the single morphine administration.
Negative_regulation (down-regulation) of Gene_expression (expression) of GRK2 in hippocampus associated with locus ceruleus, thalamus, hippocampus, cerebral cortex and morphine
1) Confidence 0.56 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384166 Disease Relevance 0.09 Pain Relevance 1.58
Coexpression of the dominant-negative mutants GRK2-K220R, arrestin-2(319-418), dynamin I-K44A, rab5A-N133I or rab7-N125I partially prevented the decline in binding of the mutant after naloxone removal.
Negative_regulation (prevented) of Spec (partially) Gene_expression (Coexpression) of GRK2 (K220R) associated with narcan
2) Confidence 0.41 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641435 Disease Relevance 0 Pain Relevance 0.81
Chronic morphine treatment resulted in 30-70% down-regulation of GRK2 expression in cerebral cortex, hippocampus, thalamus, and locus coeruleus, opposite to what observed with the single morphine administration.
Negative_regulation (down-regulation) of in thalamus Gene_expression (expression) of GRK2 in hippocampus associated with locus ceruleus, thalamus, hippocampus, cerebral cortex and morphine
3) Confidence 0.19 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384166 Disease Relevance 0.09 Pain Relevance 1.58
Chronic morphine treatment resulted in 30-70% down-regulation of GRK2 expression in cerebral cortex, hippocampus, thalamus, and locus coeruleus, opposite to what observed with the single morphine administration.
Negative_regulation (down-regulation) of in locus coeruleus Gene_expression (expression) of GRK2 in hippocampus associated with locus ceruleus, thalamus, hippocampus, cerebral cortex and morphine
4) Confidence 0.19 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384166 Disease Relevance 0.09 Pain Relevance 1.58
Chronic morphine treatment resulted in 30-70% down-regulation of GRK2 expression in cerebral cortex, hippocampus, thalamus, and locus coeruleus, opposite to what observed with the single morphine administration.
Negative_regulation (down-regulation) of in cerebral cortex Gene_expression (expression) of GRK2 in hippocampus associated with locus ceruleus, thalamus, hippocampus, cerebral cortex and morphine
5) Confidence 0.19 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384166 Disease Relevance 0.09 Pain Relevance 1.58
In addition, stable transfection of a dominant negative GRK2(Lys220Arg) mutant in the NG108-15 cells reduced the NECA-induced (30 min, 100 ?
Negative_regulation (reduced) of Gene_expression (transfection) of GRK2 (K220R) in NG108-15
6) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.06 Pain Relevance 0.17

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