INT9886

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Context Info
Confidence 0.77
First Reported 1982
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 92
Total Number 95
Disease Relevance 40.66
Pain Relevance 25.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
macrophages 3
brain 3
spinal 3
skin 3
colon 3
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 245 100.00 Very High Very High Very High
cOX1 41 100.00 Very High Very High Very High
cINOD 231 99.98 Very High Very High Very High
Central nervous system 25 99.68 Very High Very High Very High
Inflammation 565 99.60 Very High Very High Very High
Inflammatory mediators 27 99.52 Very High Very High Very High
metalloproteinase 11 99.44 Very High Very High Very High
COX2 75 99.40 Very High Very High Very High
Pain 32 99.40 Very High Very High Very High
Neuropeptide 18 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 300 99.96 Very High Very High Very High
Apoptosis 81 99.96 Very High Very High Very High
INFLAMMATION 717 99.80 Very High Very High Very High
Asthma 66 99.80 Very High Very High Very High
Retina Disease 29 99.80 Very High Very High Very High
Hemophilus Infection 89 99.74 Very High Very High Very High
Pressure And Volume Under Development 57 99.64 Very High Very High Very High
Nociception 46 99.56 Very High Very High Very High
Targeted Disruption 62 99.54 Very High Very High Very High
Injury 57 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially sensitive to inhibition by common nonsteroidal anti-inflammatory drugs (NSAIDs).
Gene_expression (expressed) of PGH associated with inflammation and cinod
1) Confidence 0.77 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8454631 Disease Relevance 0.17 Pain Relevance 0.52
Cyclooxygenase-1 was expressed strongly in inflammatory cells in the acute phase.
Gene_expression (expressed) of Cyclooxygenase-1 associated with inflammation
2) Confidence 0.75 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19879866 Disease Relevance 0.33 Pain Relevance 0.46
PGH synthase-1 is present in platelets and endothelial cells whereas PGH synthase-2 has been detected in endothelial cells treated with cytokines and phorbol esters.
Gene_expression (present) of PGH synthase-1 in endothelial cells associated with cytokine
3) Confidence 0.75 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8017762 Disease Relevance 0.08 Pain Relevance 0.32
PGH synthase-1 is expressed constitutively and is found in most tissues.
Gene_expression (expressed) of PGH synthase-1
4) Confidence 0.74 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825862 Disease Relevance 0.28 Pain Relevance 0.28
PGHS-1 is a constitutively expressed enzyme that early observations indicate is the principal enzyme involved in producing prostaglandins that regulate cellular housekeeping functions, such as gastric cytoprotection, vascular homeostasis, and kidney function.
Gene_expression (expressed) of PGHS-1 in kidney
5) Confidence 0.70 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.35 Pain Relevance 0.38
This system, using cells that express either PGHS-1 or PGHS-2, offers a convenient and reliable method to determine IC50 and IC80 values of the two PGHS isoforms, entirely independent of each other, in the same cell type.
Gene_expression (express) of PGHS-1
6) Confidence 0.67 Published 2001 Journal Inflamm. Res. Section Body Doc Link 11475335 Disease Relevance 0 Pain Relevance 0
Iloprost-induced nociception: determination of the site of anti-nociceptive action of cyclooxygenase inhibitors and the involvement of cyclooxygenase products in central mechanisms of nociception.
Gene_expression (products) of cyclooxygenase associated with nociception and analgesic
7) Confidence 0.66 Published 2010 Journal Methods Mol. Biol. Section Title Doc Link 20645177 Disease Relevance 0.76 Pain Relevance 0.76
Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring.
Gene_expression (produce) of Ptgs1
8) Confidence 0.65 Published 1995 Journal Cell Section Abstract Doc Link 8521478 Disease Relevance 0.25 Pain Relevance 0.17
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
Gene_expression (disruption) of Prostaglandin synthase 1 gene associated with inflammation
9) Confidence 0.65 Published 1995 Journal Cell Section Title Doc Link 8521478 Disease Relevance 0.26 Pain Relevance 0.18
OBJECTIVE: Cyclooxygenase isoenzyme is known to be expressed in different regions of brain, and is mainly used for the treatment of pain and inflammation.
Gene_expression (expressed) of Cyclooxygenase isoenzyme in brain associated with pain and inflammation
10) Confidence 0.65 Published 2010 Journal Neurosci Bull Section Abstract Doc Link 20101269 Disease Relevance 0.27 Pain Relevance 0.15
The two mouse PGHS isoforms, PGHS-1 and PGHS-2, were expressed in Saccharomyces cerevisiae (yeast), as was a signal-peptide-deleted version of PGHS-1 (PGHS-1MA).
Gene_expression (expressed) of PGHS
11) Confidence 0.64 Published 2009 Journal FEMS Yeast Res. Section Abstract Doc Link 19207291 Disease Relevance 0.07 Pain Relevance 0.07
Coexpression of PGHS-1 with cDNAs encoding mouse prostaglandin I synthase and thromboxane A synthase, and with Trypanosoma brucei genomic DNA encoding prostaglandin F synthase in AA-supplemented yeast cultures resulted in production of the corresponding prostanoids, prostaglandin I(2), thromboxane A(2) and prostaglandin F(2alpha).
Gene_expression (Coexpression) of PGHS-1
12) Confidence 0.64 Published 2009 Journal FEMS Yeast Res. Section Abstract Doc Link 19207291 Disease Relevance 0.15 Pain Relevance 0.25
The two mouse PGHS isoforms, PGHS-1 and PGHS-2, were expressed in Saccharomyces cerevisiae (yeast), as was a signal-peptide-deleted version of PGHS-1 (PGHS-1MA).
Gene_expression (expressed) of PGHS-1
13) Confidence 0.64 Published 2009 Journal FEMS Yeast Res. Section Abstract Doc Link 19207291 Disease Relevance 0.07 Pain Relevance 0.07
Immunohistochemical analysis suggested cyclooxygenase-2 was expressed in endothelium but not in inflammatory cells in ischemic tissue from the acute to chronic phase.
Neg (not) Gene_expression (expressed) of cyclooxygenase in endothelium associated with inflammation
14) Confidence 0.58 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19879866 Disease Relevance 0.39 Pain Relevance 0.51
Tenidap, a compound reported to inhibit 5-lipoxygenase, cyclooxygenase and cytokine production, also stimulated TNF alpha production while the 5-lipoxygenase inhibitor, phenidone, was inactive.
Gene_expression (production) of cyclooxygenase associated with cytokine
15) Confidence 0.58 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.65 Pain Relevance 0.68
The indomethacin sensitivity of O3-induced changes in PD may reflect a role of cyclooxygenase products in that response.
Gene_expression (products) of cyclooxygenase
16) Confidence 0.57 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7878675 Disease Relevance 0.13 Pain Relevance 0.18
These results establish that the two mouse enzymes are pharmacologically distinct and suggest that it will be possible to identify or design compounds that are completely selective for each PGHS isozyme.
Gene_expression (selective) of PGHS isozyme
17) Confidence 0.57 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8017762 Disease Relevance 0.24 Pain Relevance 0.54
The two mouse PGHS isoforms, PGHS-1 and PGHS-2, were expressed in Saccharomyces cerevisiae (yeast), as was a signal-peptide-deleted version of PGHS-1 (PGHS-1MA).
Gene_expression (expressed) of PGHS
18) Confidence 0.56 Published 2009 Journal FEMS Yeast Res. Section Abstract Doc Link 19207291 Disease Relevance 0.07 Pain Relevance 0.07
The inhibitory effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on prostanoid production were tested on yeast cells expressing PGHS-1 in AA-supplemented culture.
Gene_expression (expressing) of PGHS-1 associated with inflammation and cinod
19) Confidence 0.56 Published 2009 Journal FEMS Yeast Res. Section Abstract Doc Link 19207291 Disease Relevance 0.17 Pain Relevance 0.40
Cloning of complementary DNAs for murine PGHS-1 and PGHS-2 has permitted individual expression of these two isozymes in the cos-1 cell system and comparison of their relative inhibition by several common NSAIDs in vitro.
Gene_expression (expression) of PGHS-1 associated with cinod
20) Confidence 0.55 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357002 Disease Relevance 0.17 Pain Relevance 0.29

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