INT98869

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GNAT1) signal transduction (GNAT1) plasma membrane (GNAT1)
GTPase activity (GNAT1) cytoplasm (GNAT1) signal transducer activity (GNAT1)
Anatomy Link Frequency
CHO 3
GNAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 100.00 Very High Very High Very High
Opioid 6 98.34 Very High Very High Very High
MU agonist 3 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the expression of alpha-transducin scavenges free G(beta gamma) subunits and, furthermore, that free G(beta gamma) subunits play a role in opioid-mediated PLC beta activation and adenylyl cyclase superactivation, but not acute inhibition of forskolin-stimulated cAMP formation in hDOR/CHO cells.
Gene_expression (expression) of alpha-transducin in CHO associated with opioid
1) Confidence 0.13 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0.08 Pain Relevance 0.25
Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.
Gene_expression (Expression) of alpha-transducin in ovary associated with mu agonist and opioid receptor
2) Confidence 0.13 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11641436 Disease Relevance 0.05 Pain Relevance 0.30
To investigate the role of G-protein beta gamma subunits in delta-opioid signal transduction, we have transfected Chinese hamster ovary (CHO) cells stably expressing the human delta-opioid receptor (hDOR/CHO cells) with the G(alpha)-subunit of transducin-1 (hDOR/T1/CHO).
Gene_expression (expressing) of transducin-1 in CHO associated with opioid receptor and opioid
3) Confidence 0.10 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0 Pain Relevance 0.26

General Comments

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