INT9887

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.94
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
sperm 2
microglial cells 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 100.00 Very High Very High Very High
COX2 5 99.50 Very High Very High Very High
cINOD 14 99.00 Very High Very High Very High
Inflammatory mediators 5 97.76 Very High Very High Very High
Paracetamol 1 95.72 Very High Very High Very High
aspirin 9 94.24 High High
adenocard 5 94.00 High High
Potency 1 93.84 High High
Inflammatory response 1 93.56 High High
Pain 2 88.40 High High
Disease Link Frequency Relevance Heat
Polyps 3 99.96 Very High Very High Very High
Pressure And Volume Under Development 20 98.48 Very High Very High Very High
INFLAMMATION 26 98.28 Very High Very High Very High
Acute Erythroblastic Leukemia 1 92.44 High High
Pain 2 88.40 High High
Disease 3 87.52 High High
Inflammatory Bowel Disease 1 79.64 Quite High
Retina Disease 25 78.28 Quite High
Cancer 4 75.00 Quite High
Necrosis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially sensitive to inhibition by common nonsteroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (sensitive) of Gene_expression (expressed) of PGH associated with inflammation and cinod
1) Confidence 0.42 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8454631 Disease Relevance 0.17 Pain Relevance 0.54
Tenidap, a compound reported to inhibit 5-lipoxygenase, cyclooxygenase and cytokine production, also stimulated TNF alpha production while the 5-lipoxygenase inhibitor, phenidone, was inactive.
Negative_regulation (inhibit) of Gene_expression (production) of cyclooxygenase associated with cytokine
2) Confidence 0.41 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.65 Pain Relevance 0.69
In the present study, we show that homologous disruption of either Ptgs-1 or Ptgs-2 (genes coding for COX-1 or COX-2, respectively) reduced polyp formation in Min/+ mice by approximately 80%.
Negative_regulation (reduced) of Gene_expression (disruption) of Ptgs-1 associated with polyps
3) Confidence 0.25 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10987272 Disease Relevance 0.26 Pain Relevance 0.06
MATERIALS AND METHODS: Since the major mechanism of action attributed to aspirin is the inhibition of cyclooxygenase (COX), prostaglandin (PG) production was examined under differentiation-inducing conditions in MEL cells.
Negative_regulation (inhibition) of Spec (examined) Gene_expression (production) of cyclooxygenase
4) Confidence 0.11 Published 2003 Journal Anticancer Res. Section Body Doc Link 12680248 Disease Relevance 0.09 Pain Relevance 0
Olsalazine treatment decreased all cyclooxygenase and lipoxygenase products to baseline levels.
Negative_regulation (decreased) of Gene_expression (products) of cyclooxygenase
5) Confidence 0.08 Published 1992 Journal Agents Actions Section Abstract Doc Link 1442339 Disease Relevance 0.40 Pain Relevance 0.16
Armeniacae semen extract suppresses lipopolysaccharide-induced expressions of cyclooxygenase [correction of cycloosygenase]-2 and inducible nitric oxide synthase in mouse BV2 microglial cells.
Negative_regulation (suppresses) of Gene_expression (expressions) of cyclooxygenase in microglial cells associated with cox2
6) Confidence 0.07 Published 2005 Journal Biol. Pharm. Bull. Section Title Doc Link 15744067 Disease Relevance 0.35 Pain Relevance 0.31
These findings state that cyclooxygenase is constitutively expressed in mice testis and continuous inhibition of COX-2 interferes in maturation of sperm.
Negative_regulation (interferes) of Gene_expression (expressed) of cyclooxygenase in sperm
7) Confidence 0.07 Published 2007 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 17624748 Disease Relevance 0.19 Pain Relevance 0.23
The selective inhibitors of phospholipase A2, 4-bromophenacyl bromide (300 µM), and of cyclooxygenase, indomethacin (10 µM), prevented the swelling of Müller cells from Dp71-null mice (Fig. 5C; 103.3±2.1%, n?
Negative_regulation (inhibitors) of Gene_expression (selective) of cyclooxygenase associated with pressure and volume under development
8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.82 Pain Relevance 0.31

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