INT98888

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.72
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 15 100.00 Very High Very High Very High
cINOD 14 99.98 Very High Very High Very High
Inflammation 19 94.96 High High
Angina 1 91.08 High High
Analgesic 1 65.16 Quite High
Pain 2 64.24 Quite High
Arthritis 1 62.16 Quite High
aspirin 4 57.68 Quite High
Inflammatory response 5 25.00 Low Low
cva 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 2 98.40 Very High Very High Very High
INFLAMMATION 22 94.96 High High
Toxicity 3 93.96 High High
Death 2 91.44 High High
Cv General 3 Under Development 14 91.08 High High
Cardiovascular Disease 1 86.60 High High
Pneumonia 7 84.96 Quite High
Endotoxemia 5 83.72 Quite High
Myocardial Infarction 2 83.72 Quite High
Critical Illness 27 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury.
Negative_regulation (inhibits) of Gene_expression (Neutralization) of interleukin-18 associated with vasculitis
1) Confidence 0.43 Published 2006 Journal Circulation Section Title Doc Link 16864728 Disease Relevance 0.45 Pain Relevance 0.09
Indeed, NO-NSAIDs suppress production of the cytokines interleukin (IL)-1beta, IL-18 and interferon-gamma by causing the S-nitrosilation/inhibition of caspase-1.
Negative_regulation (suppress) of Gene_expression (production) of IL-18 associated with cinod and cytokine
2) Confidence 0.13 Published 2001 Journal Drug Saf Section Abstract Doc Link 11665868 Disease Relevance 0.59 Pain Relevance 1.56
In a series of elegant experiments, Boost and collaborators showed that a caspase-1 inhibitor administered by inhalation in endotoxemic rats decreased IL-1 and IL-18 levels in bronchoalveolar lavage fluid [18].
Negative_regulation (decreased) of Gene_expression (levels) of IL-18
3) Confidence 0.06 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.67 Pain Relevance 0.37

General Comments

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