INT9889

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 20.83
Pain Relevance 8.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
brain 6
heart 4
plasma 2
aorta 2
sensory neurons 1
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 212 99.98 Very High Very High Very High
bradykinin 3 99.90 Very High Very High Very High
Central nervous system 192 99.62 Very High Very High Very High
qutenza 2 99.60 Very High Very High Very High
licofelone 10 99.58 Very High Very High Very High
Hippocampus 173 99.44 Very High Very High Very High
ischemia 44 98.16 Very High Very High Very High
Inflammatory response 15 97.44 Very High Very High Very High
Arthritis 6 96.40 Very High Very High Very High
cytokine 11 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 240 99.98 Very High Very High Very High
Aging 743 99.82 Very High Very High Very High
Chronic Renal Failure 40 99.36 Very High Very High Very High
Disease 156 99.20 Very High Very High Very High
Nociception 3 98.82 Very High Very High Very High
Apoptosis 33 98.48 Very High Very High Very High
Brain Hemorrhage 19 98.40 Very High Very High Very High
Atherosclerosis 5 98.28 Very High Very High Very High
Amyloid Plaque 14 97.24 Very High Very High Very High
Disease Progression 20 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regardless of the observed regional differences, all previous studies [14, 17, 37] and our present results are consistent as to the direction (i.e., increase) of aging-associated changes in brain 5-LOX expression.
Gene_expression (expression) of 5-LOX in brain associated with aging
1) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.80 Pain Relevance 0.11
Nevertheless, there is evidence for 5-LOX expression in these organs/systems [6, 14–16].
Gene_expression (expression) of 5-LOX
2) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.81 Pain Relevance 0.41
This information appears necessary for a full understanding of the biological implications of aging-altered expression of 5-LOX in the brain and heart.
Gene_expression (expression) of 5-LOX in heart associated with aging
3) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.44 Pain Relevance 0.24
Furthermore, in the heart, that is, myocardial cells, drugs such as statins and thiazolidinediones trigger anti-inflammatory processes and increase the production of anti-inflammatory lipoxins depending on 5-LOX, particularly the status of 5-LOX phosphorylation [15, 23].
   5-LOX gene expression is regulated by epigenetic mechanisms including modifications of DNA methylation [1, 24–26]. 
Gene_expression (expression) of 5-LOX in myocardial cells associated with inflammation
4) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.57 Pain Relevance 0.28
Although leukotriene synthesis in the CNS and in the heart can occur via a transcellular biosynthetic pathway that is believed not to require 5-LOX expression [12, 13], aging-increased leukotriene synthesis in the hippocampus [14] and aorta [38] appears to be associated with increased 5-LOX expression.
Gene_expression (expression) of 5-LOX in aorta associated with aging, hippocampus and central nervous system
5) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.23 Pain Relevance 0.24
Thus, regulation of the brain expression of 5-LOX participates in mechanisms of neuroprotection [8].
Gene_expression (expression) of 5-LOX in brain
6) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.87 Pain Relevance 0.44
Although leukotriene synthesis in the CNS and in the heart can occur via a transcellular biosynthetic pathway that is believed not to require 5-LOX expression [12, 13], aging-increased leukotriene synthesis in the hippocampus [14] and aorta [38] appears to be associated with increased 5-LOX expression.
Gene_expression (expression) of 5-LOX in aorta associated with aging, hippocampus and central nervous system
7) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.31 Pain Relevance 0.26
We observed that in the heart, which expresses about 50 times greater 5-LOX mRNA levels than the brain, the DNA regions targeted by BstUI, HinP1I, and HpaII were less methylated than those in the brain.
Gene_expression (expresses) of 5-LOX in brain
8) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.45 Pain Relevance 0
In the CNS of rats and mice, 5-LOX expression increases during aging [14, 17] and in brain ischemia [18, 19].
Gene_expression (expression) of 5-LOX in brain associated with brain hemorrhage, aging, ischemia and central nervous system
9) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.90 Pain Relevance 0.45
To our knowledge, this is the first time that heart 5-LOX expression has been investigated in the context of aging.
Gene_expression (expression) of 5-LOX in heart associated with aging
10) Confidence 0.63 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.82 Pain Relevance 0.10
Overexpression of 5-LOX in NIH3T3 cells resulted in greater sensitivity of these cells to the growth inhibitory effects of the 5-LOX inhibitor Rev5901.
Gene_expression (Overexpression) of 5-LOX
11) Confidence 0.60 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16024599 Disease Relevance 0.50 Pain Relevance 0.09
Results

Figure 3 shows that the expression levels of 5-LOX mRNA in heart tissue are about fifty times greater than in brain tissue.

Gene_expression (expression) of 5-LOX in heart
12) Confidence 0.54 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.26 Pain Relevance 0
Although no changes in 5-LO or 12-LO expression were seen by Western blot analysis or by immunohistochemistry in spinal cords of dipyrone-treated mice, the activation of both enzymes was verified by determining LO-products.
Gene_expression (expression) of 5-LO in spinal cords
13) Confidence 0.53 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.25 Pain Relevance 0.28
Similarly, cell type may be decisive in determining the type of 5-LOX metabolites produced (e.g., leukotrienes versus lipoxins).
Gene_expression (produced) of 5-LOX
14) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.14 Pain Relevance 0.18
The reason for these discrepancies is not apparent, but considering the putative epigenetic regulation of 5-LOX expression, it is likely that individual life experiences of various colonies of old rodents could result in a colony-specific aging-modified epigenetic regulation of 5-LOX expression.
Gene_expression (expression) of 5-LOX associated with aging
15) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.84 Pain Relevance 0.12
These differences do not appear to be species-related (e.g., rat versus mouse) because others found that aging increases 5-LOX expression in the mouse hippocampus but not in the cerebellum and cortex [14].
Gene_expression (expression) of 5-LOX in cortex associated with aging and hippocampus
16) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.76 Pain Relevance 0.17
5-Lipoxygenase DNA Methylation and mRNA Content in the Brain and Heart of Young and Old Mice

The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation.

Gene_expression (expression) of 5-LOX in Brain associated with aging
17) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Title Doc Link PMC2801004 Disease Relevance 0.37 Pain Relevance 0
The reason for these discrepancies is not apparent, but considering the putative epigenetic regulation of 5-LOX expression, it is likely that individual life experiences of various colonies of old rodents could result in a colony-specific aging-modified epigenetic regulation of 5-LOX expression.
Gene_expression (expression) of 5-LOX associated with aging
18) Confidence 0.49 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.77 Pain Relevance 0.13
The authors propose that NNK-derived intermediates induce the expression of COX-2 and lipoxygenase involved in NNK activation.
Gene_expression (expression) of lipoxygenase
19) Confidence 0.46 Published 1998 Journal Exp. Lung Res. Section Abstract Doc Link 9659586 Disease Relevance 0.30 Pain Relevance 0.19
Our findings confirm that Me-UCH9 can modulate inflammatory and nociceptive responses in relation to the dual inhibition of COX-2 and 5-LO activities presented by this compound.
Gene_expression (presented) of 5-LO associated with nociception and inflammation
20) Confidence 0.22 Published 2007 Journal Life Sci. Section Abstract Doc Link 17490689 Disease Relevance 1.13 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox