INT989

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 90
Total Number 93
Disease Relevance 15.45
Pain Relevance 43.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
thyroid 4
spinal cord 4
brain 3
pituitary 3
medulla 3
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 104 100.00 Very High Very High Very High
substance P 99 100.00 Very High Very High Very High
cytokine 75 100.00 Very High Very High Very High
Spinal cord 39 100.00 Very High Very High Very High
Hippocampus 34 100.00 Very High Very High Very High
medulla 31 100.00 Very High Very High Very High
Somatostatin 21 100.00 Very High Very High Very High
tetrodotoxin 13 100.00 Very High Very High Very High
Intracerebroventricular 7 100.00 Very High Very High Very High
Antinociceptive 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alcohol Addiction 4 99.80 Very High Very High Very High
Urological Neuroanatomy 33 99.68 Very High Very High Very High
Appetite Loss 2 99.68 Very High Very High Very High
Opiate Addiction 1 99.20 Very High Very High Very High
Pressure Volume 2 Under Development 8 99.16 Very High Very High Very High
Convulsion 2 99.04 Very High Very High Very High
INFLAMMATION 131 99.00 Very High Very High Very High
Dysmenorrhea 10 98.88 Very High Very High Very High
Stress 123 98.48 Very High Very High Very High
Stupor 5 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inability of higher doses of TRH to inhibit tolerance to morphine may be related to rapid down-regulation of TRH receptors.
Negative_regulation (down-regulation) of TRH associated with tolerance and morphine
1) Confidence 0.59 Published 1990 Journal Neuropeptides Section Abstract Doc Link 2124334 Disease Relevance 0 Pain Relevance 1.29
The results showed that: 1) Injection of TRH into the nucleus accumbens resulted in a significant inhibition of pain discharges from PEN in nucleus parafascicularis, while injection of TRH into nucleus amygdalae, nucleus caudatus exerted no significant effect. 2) Pretreatment with atropine abolished the above-mentioned effect of TRH. 3) Pretreatment with haloperidol also abolished the above-mentioned inhibitory effect of TRH. 4) Pretreatment with naloxone, propranolol or phentolamine did not affect the inhibitory effect of TRH.
Negative_regulation (effect) of TRH in nucleus accumbens associated with pain, nucleus accumbens and narcan
2) Confidence 0.59 Published 1991 Journal J. Tongji Med. Univ. Section Abstract Doc Link 1819028 Disease Relevance 0.24 Pain Relevance 0.54
The attenuation of thyrotropin (TSH) responsiveness to a second injection of thyrotropin-releasing hormone (TRH) was studied in adult female rats.
Negative_regulation (attenuation) of TRH
3) Confidence 0.59 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6403887 Disease Relevance 0.07 Pain Relevance 0.07
A novel analog of TRH, YM14673, causes a decrease in brain TRH receptors in vitro.
Negative_regulation (decrease) of TRH in brain
4) Confidence 0.59 Published 1995 Journal Endocr. Res. Section Title Doc Link 8582330 Disease Relevance 0 Pain Relevance 0.17
But injection of TRH into nucleus amygdaloid, nucleus caudate-putamen had no significant effect. (2) Pretreatment with auropine abolished the inhibitory effect of TRH. (3) Pretreatment with haloperidol also abolished the inhibitory effect of TRH. (4) Pretreatment with naloxone, propranolol or phentolamine did not affect the inhibitory effect of TRH.
Negative_regulation (effect) of TRH in nucleus associated with narcan
5) Confidence 0.59 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2125882 Disease Relevance 0.24 Pain Relevance 0.57
After 1 h injection, TRH levels were increased in hippocampus and decreased in n. accumbens; after 4 h, it decreased in the hypothalamus, frontal cortex and amygdala, recovering to control values in all regions at 24 h.
Negative_regulation (decreased) of TRH in frontal cortex associated with urological neuroanatomy, hippocampus and amygdala
6) Confidence 0.59 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.44 Pain Relevance 0.34
Scatchard analyses of competition data revealed that 50 microM SP reduced TRH receptor number (40-66%, P less than 0.05) with little or no effect on affinity.
Negative_regulation (reduced) of TRH associated with substance p
7) Confidence 0.57 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6200806 Disease Relevance 0 Pain Relevance 0.63
On the other hand, thyrotropin-releasing hormone (TRH) was significantly decreased in cerebellum and hippocampus of NLX-rats, while it did not show any changes in cerebral cortex, medulla and pons of NLX-rats.
Negative_regulation (decreased) of thyrotropin-releasing hormone in medulla associated with medulla, narcan, hippocampus and cerebral cortex
8) Confidence 0.43 Published 1988 Journal Life Sci. Section Abstract Doc Link 3137406 Disease Relevance 0.31 Pain Relevance 1.28
On the other hand, thyrotropin-releasing hormone (TRH) was significantly decreased in cerebellum and hippocampus of NLX-rats, while it did not show any changes in cerebral cortex, medulla and pons of NLX-rats.
Negative_regulation (decreased) of TRH in medulla associated with medulla, narcan, hippocampus and cerebral cortex
9) Confidence 0.43 Published 1988 Journal Life Sci. Section Abstract Doc Link 3137406 Disease Relevance 0.30 Pain Relevance 1.27
We also found that TRH reduced in a concentration-dependent manner both the fast transient A-type K+ current (IA) and the Ca(2+)-dependent afterhyperpolarizing current (IAHP).
Negative_regulation (reduced) of TRH
10) Confidence 0.43 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1329553 Disease Relevance 0 Pain Relevance 0.17
The Ba(2+)-sensitive and TRH-sensitive resting K+ conductances are apparently identical; in the presence of Ba2+, the customary TRH-induced decrease in conductance was occluded. 5.
Negative_regulation (decrease) of TRH
11) Confidence 0.43 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1479442 Disease Relevance 0 Pain Relevance 0.05
The inhibitory effect of DHET on ENK binding was competitive, and an allosteric effect seems to be involved in the DHET inhibition of TRH binding to its receptor.
Negative_regulation (inhibition) of TRH associated with enkephalin
12) Confidence 0.43 Published 1984 Journal Peptides Section Abstract Doc Link 6324150 Disease Relevance 0 Pain Relevance 0.69
There was a parallel reduction in substance P and TRH in ventral spinal cord while methionine-enkephalin and somatostatin in ventral and dorsal cord increased. 4.
Negative_regulation (reduction) of TRH in ventral associated with somatostatin, enkephalin, spinal cord and substance p
13) Confidence 0.43 Published 1982 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Section Abstract Doc Link 6183051 Disease Relevance 0 Pain Relevance 0.62
At 2 h after the last morphine injection, the Bmax of TRH receptors was decreased in the nucleus accumbens (by ca 41%) and unchanged in other structures, whereas at 72 h it was elevated by ca 27% and 49% in the striatum and hippocampus, respectively.
Negative_regulation (decreased) of TRH in hippocampus associated with nucleus accumbens, hippocampus and morphine
14) Confidence 0.43 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837962 Disease Relevance 0 Pain Relevance 0.95
Intestinal perfusion with graded concentrations of HCl (50, 75, and 100 mM) for 1 h dose dependently inhibited both thyrotropin-releasing hormone (TRH) analogue- and pentagastrin-stimulated acid output (P < 0.01).
Negative_regulation (inhibited) of thyrotropin-releasing hormone
15) Confidence 0.43 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7864125 Disease Relevance 0 Pain Relevance 0.35
[Effect of intracerebroventricular injection of thyrotropin releasing hormone on electro-acupuncture analgesia and the content of cerebral cAMP in rats].
Negative_regulation (injection) of thyrotropin releasing hormone associated with pain, acupuncture, intracerebroventricular and analgesia
16) Confidence 0.43 Published 1990 Journal Zhen Ci Yan Jiu Section Title Doc Link 2177383 Disease Relevance 0.42 Pain Relevance 1.10
Naloxone (10(-6) M) had no effect when added alone to the medium, but reversed the opiate inhibition of TRH release.
Negative_regulation (inhibition) of TRH associated with narcan and opiate
17) Confidence 0.43 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.84
Both opiates (morphine, 10(-6) M; leucine enkephalin, 10(-6) M) did not modify the spontaneous release of TRH, but significantly decreased the depolarization-induced TRH release.
Neg (not) Negative_regulation (decreased) of TRH associated with enkephalin, opiate and morphine
18) Confidence 0.43 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.85
Perfusion with 10(-6)M morphine blocked the cold-induced TRH peak occurring about 40 min after the transfer of rats from 24 degrees C to 4 degrees C.
Negative_regulation (blocked) of TRH associated with morphine
19) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.59
The results showed that: 1) Injection of TRH into the nucleus accumbens resulted in a significant inhibition of pain discharges from PEN in nucleus parafascicularis, while injection of TRH into nucleus amygdalae, nucleus caudatus exerted no significant effect. 2) Pretreatment with atropine abolished the above-mentioned effect of TRH. 3) Pretreatment with haloperidol also abolished the above-mentioned inhibitory effect of TRH. 4) Pretreatment with naloxone, propranolol or phentolamine did not affect the inhibitory effect of TRH.
Negative_regulation (effect) of TRH in nucleus accumbens associated with pain, nucleus accumbens and narcan
20) Confidence 0.43 Published 1991 Journal J. Tongji Med. Univ. Section Abstract Doc Link 1819028 Disease Relevance 0.25 Pain Relevance 0.55

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