INT98919

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.40
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
chondrocytes 4
synovial cells 2
primary visual cortex 2
dorsal horn 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal dorsal horn 3 99.68 Very High Very High Very High
alcohol 50 98.74 Very High Very High Very High
imagery 14 97.12 Very High Very High Very High
opioid receptor 4 93.20 High High
allodynia 2 92.16 High High
Opioid 4 91.28 High High
agonist 9 86.36 High High
Arthritis 2 84.64 Quite High
Inflammation 37 83.52 Quite High
analgesia 2 82.36 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 2 98.44 Very High Very High Very High
Neuropathic Pain 6 92.16 High High
Osteoarthritis 4 90.52 High High
Death 1 87.64 High High
Apoptosis 3 87.20 High High
Arthritis 2 84.64 Quite High
INFLAMMATION 55 83.52 Quite High
Intellectual Impairment 2 82.28 Quite High
Nervous System Injury 5 78.56 Quite High
Hypersensitivity 1 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of chondrocytes with beta-endorphin resulted in decreased phosphorylation of the transcription factor cAMP responsive element binding protein (CREB).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of cAMP responsive element binding protein in chondrocytes
1) Confidence 0.58 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.33 Pain Relevance 0.63
Stimulation of chondrocytes with beta-endorphin resulted in decreased phosphorylation of the transcription factor cAMP responsive element binding protein (CREB).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of CREB in chondrocytes
2) Confidence 0.42 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.33 Pain Relevance 0.63
Western blot results showed that the alleviation in intensity of behavioral performance was accompanied by a significant reduction of total cyclic AMP response element-binding protein and phosphorylated cyclic AMP response element-binding protein in the spinal dorsal horn.
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of cyclic AMP response element-binding protein in dorsal horn associated with spinal dorsal horn
3) Confidence 0.42 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.81 Pain Relevance 0.70
Melanoma cells homozygous for either the Arg151Cys variant or consensus sequence both elicited CREB phosphorylation in response to alpha-MSH in the presence of IBMX.
Negative_regulation (elicited) of Phosphorylation (phosphorylation) of CREB associated with skin cancer
4) Confidence 0.40 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.17 Pain Relevance 0.33
Here we show that the primary visual cortex of ferrets exposed to alcohol during the third trimester equivalent of human gestation have decreased CREB phosphorylation and poor orientation selectivity revealed by western blotting, optical imaging of intrinsic signals and single-unit extracellular recording techniques.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of CREB in primary visual cortex associated with imagery and alcohol
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2721629 Disease Relevance 0.08 Pain Relevance 0.22
M Rp-cAMPS significantly blocked the isoproterenol mediated CREB phosphorylation (n = 3).
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of CREB
6) Confidence 0.24 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.19 Pain Relevance 0.09
Thus, it was suggested that the action of cilostazol to promote cell survival was ascribed to the maxi-K channel opening-coupled upregulation of CK2 phosphorylation and downregulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB.
Negative_regulation (downregulation) of Phosphorylation (phosphorylation) of CREB
7) Confidence 0.20 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.36 Pain Relevance 0.03
The opioid peptides inhibited nuclear translocation and phosphorylation of the transcription factor, cyclic AMP responsive element binding protein (CREB) in RA synovial cells.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of cyclic AMP responsive element binding protein in synovial cells
8) Confidence 0.11 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669152 Disease Relevance 0.11 Pain Relevance 0

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