INT98923

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
synovial cells 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 9 100.00 Very High Very High Very High
Kinase C 4 99.52 Very High Very High Very High
Morphine 9 93.44 High High
Dorsal column 6 88.08 High High
Central grey 87 86.40 High High
narcan 2 68.04 Quite High
Enkephalin 2 50.00 Quite Low
rheumatoid arthritis 2 50.00 Quite Low
amygdala 58 24.24 Low Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1 98.32 Very High Very High Very High
Urological Neuroanatomy 95 86.40 High High
Stress 101 83.80 Quite High
Cold Sores 21 82.04 Quite High
Rheumatoid Arthritis 3 57.36 Quite High
Anxiety Disorder 29 50.00 Quite Low
Post-traumatic Stress Disorder 14 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PKC inhibitor calphostin C reduced the withdrawal-triggered rise in pCREB, pERK(1/2), TH expression and corticosterone secretion.
Negative_regulation (reduced) of Localization (secretion) of pCREB associated with kinase c and withdrawal
1) Confidence 0.50 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.16 Pain Relevance 1.15
predator stressed and Handled CREB rats exhibited more pCREB lir in the right over the left (all t, P < .04,
Negative_regulation (exhibited) of Localization (lir) of pCREB
2) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.38 Pain Relevance 0.11
The opioid peptides inhibited nuclear translocation and phosphorylation of the transcription factor, cyclic AMP responsive element binding protein (CREB) in RA synovial cells.
Negative_regulation (inhibited) of Localization (translocation) of CREB in synovial cells
3) Confidence 0.02 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11669152 Disease Relevance 0.11 Pain Relevance 0

General Comments

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