INT98927

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Context Info
Confidence 0.71
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.42
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
neuronal 1
synaptic vesicles 1
spinal cord dorsal horn 1
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 54 100.00 Very High Very High Very High
Glutamate receptor 13 100.00 Very High Very High Very High
Spinal cord 18 98.64 Very High Very High Very High
Dorsal horn 10 98.16 Very High Very High Very High
Face pain 2 97.80 Very High Very High Very High
antagonist 17 96.32 Very High Very High Very High
tetrodotoxin 9 95.16 Very High Very High Very High
Dopamine 6 94.58 High High
nMDA receptor 23 89.52 High High
Neurotransmitter 1 88.80 High High
Disease Link Frequency Relevance Heat
Facial Pain 2 97.80 Very High Very High Very High
Nociception 15 66.20 Quite High
Hypoxia 144 61.84 Quite High
Depression 4 54.16 Quite High
Ganglion Cysts 13 30.16 Quite Low
Stress 5 6.92 Low Low
Pain 10 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The metabotropic glutamate receptor 1 immunoreactive product was localized mostly in dendrites, while most of the metabotropic glutamate receptors 2/3 immunoreactive product was deposited in axon terminals containing synaptic vesicles of different shapes, suggesting that glutamate receptors 2/3 may control the release of both excitatory and inhibitory neurotransmitters.
Localization (localized) of metabotropic glutamate receptor 1 immunoreactive product in synaptic vesicles associated with neurotransmitter and glutamate receptor
1) Confidence 0.71 Published 2001 Journal J. Dent. Res. Section Abstract Doc Link 11669485 Disease Relevance 0.25 Pain Relevance 0.62
Although the synaptic localization of mGluR1 and mGluR5 has been known in the spinal cord dorsal horn [20,21], it has not been clearly demonstrated in the Vo.
Localization (localization) of mGluR1 in spinal cord dorsal horn associated with dorsal horn and spinal cord
2) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.05 Pain Relevance 0.37
Taken together, these results indicate that mGluR1 and mGluR5 additively contribute to the glutamate release at presynaptic terminals in the Vo, while two subtypes compensate each other for the potentiation of postsynaptic responses.
Localization (release) of mGluR1 associated with glutamate
3) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0 Pain Relevance 0.39
DHPG-induced rise of extracellular dopamine was reversed by tetrodotoxin and by the selective mGlu1 and mGlu5 receptor antagonists 7(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate (CPCCOEt) and 2-methyl-6-(phenylethynyl)pyridine (MPEP) either ICV or into the ventrotegmental area (VTA), suggesting that neuronal release and both mGlu1 and mGlu5 receptors were involved.
Localization (release) of mGlu1 in neuronal associated with tetrodotoxin, dopamine and antagonist
4) Confidence 0.22 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17176263 Disease Relevance 0 Pain Relevance 0.45
We found 22 of these genes were represented on our focused array (GPR51, GRIA3, GRIA4, GRID2, GRIK 1, GRIK3, GRIK4, GRIN1, GRIN2A GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, and GUCY2F).
Localization (array) of GRM1
5) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.13

General Comments

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