INT9895

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.80
Pain Relevance 5.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GHR) extracellular space (GHR) extracellular region (GHR)
plasma membrane (GHR) nucleus (GHR) cytoplasm (GHR)
Anatomy Link Frequency
plasma 1
CSF 1
urine 1
GHR (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 42 100.00 Very High Very High Very High
local anesthetic 12 100.00 Very High Very High Very High
methadone 2 99.84 Very High Very High Very High
lidocaine 16 99.70 Very High Very High Very High
neuralgia 6 99.48 Very High Very High Very High
Abstinence syndrome 1 98.52 Very High Very High Very High
Pain 10 97.80 Very High Very High Very High
Paracetamol 14 97.52 Very High Very High Very High
Trigeminal neuralgia 3 94.84 High High
cINOD 3 85.88 High High
Disease Link Frequency Relevance Heat
Aging 4 99.92 Very High Very High Very High
Cancer 38 99.84 Very High Very High Very High
Urinary Tract Infection 4 98.44 Very High Very High Very High
Syndrome 16 98.08 Very High Very High Very High
Pain 2 97.80 Very High Very High Very High
Sprains And Strains 1 96.12 Very High Very High Very High
Epilepsy 3 95.32 Very High Very High Very High
Headache 5 94.84 High High
Burns 4 93.40 High High
Congenital Anomalies 1 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The electrode system could also measure LA in human plasma at 37 degrees C, although the responsiveness was depressed in the low concentration range owing to binding of LA to the serum protein.
serum protein Binding (binding) of in plasma associated with local anesthetic
1) Confidence 0.36 Published 1992 Journal Anesth. Analg. Section Abstract Doc Link 1443694 Disease Relevance 0 Pain Relevance 0.86
Over 250 cases of defects of GH receptors (GHR) have been described to date and over 60 of them are due to GHR gene mutations affecting the capacity of the receptor of binding, dimerizing, migrating, or initiating postreceptor cascade.6 Also mutations in STAT-5b,7 IGF-1,8 that leads to a bioinactive IGF-1, and acid labile subunit (ALS)9 genes, have been reported.


GHR Binding (dimerizing) of
2) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.74 Pain Relevance 0
When administered to healthy subjects, etodolac had no pharmacokinetic interactions with three other drugs that are highly bound to serum protein: warfarin, glyburide, and phenytoin.
serum protein Binding (bound) of
3) Confidence 0.30 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2525982 Disease Relevance 0.43 Pain Relevance 0.40
Biopharmaceutical properties include serum protein binding of approximately 70%, 50-60% excretion of intact drug in the urine of patients with normal renal function, and an elimination half-life of approximately one hour.
serum protein Binding (binding) of in urine
4) Confidence 0.25 Published 1982 Journal Pharmacotherapy Section Abstract Doc Link 6763208 Disease Relevance 0.84 Pain Relevance 0.07
bind to GHBP.
GHBP Binding (bind) of
5) Confidence 0.08 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.23 Pain Relevance 0
To evaluate the effects of ageing on carbamazepine-serum protein binding, the patients were divided into three groups according to age: children, 4-15 years; adults, 16-64 years; elderly, 65-83 years.
carbamazepine-serum protein Binding (binding) of associated with aging and carbamazepine
6) Confidence 0.08 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10528982 Disease Relevance 0.23 Pain Relevance 0.55
To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period.
carbamazepine-serum protein Binding (binding) of associated with epilepsy, trigeminal neuralgia and carbamazepine
7) Confidence 0.08 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10528982 Disease Relevance 0.19 Pain Relevance 0.39
Age-related alteration of carbamazepine-serum protein binding in man.
carbamazepine-serum protein Binding (binding) of associated with neuralgia and carbamazepine
8) Confidence 0.08 Published 1999 Journal J. Pharm. Pharmacol. Section Title Doc Link 10528982 Disease Relevance 0.23 Pain Relevance 0.69
binding protein (GHBP) to binding site 1, was estimated to reveal
GHBP Binding (binding) of
9) Confidence 0.06 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.19 Pain Relevance 0
binding protein (GHBP) to binding site 1, was estimated to reveal
GHBP Binding (binding) of
10) Confidence 0.06 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.19 Pain Relevance 0
The steadily increasing CSF lidocaine/serum total lidocaine ratio throughout the period of study up to 120 min and the higher level in CSF than the corresponding unbound fraction of the total serum lidocaine indicate that serum protein binding is not the sole determinant of the penetration of lidocaine into lumbar CSF.
serum protein Binding (binding) of in CSF associated with lidocaine
11) Confidence 0.05 Published 1983 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6662163 Disease Relevance 0.07 Pain Relevance 0.92
For example, although immunoaffinity purification removes the major abundant serum proteins, significant losses of low abundant proteins bound to the high abundant proteins can occur.12 Therefore, a stable isotope labeled proteome (SILAP) standard added to serum samples prior to immunopurification can act as a carrier for the low abundance proteins, controlling for and minimizing the possibility of such losses.13,14 The SILAP standard can also control for and help to prevent losses that can occur throughout the extensive workup procedure and LC-MS analysis, such as the nonspecific binding of peptides to glassware and surfaces.15 Equally important, for any protein identified in the SILAP standard, the corresponding unlabeled serum protein can be quantified, if present.
serum protein Binding (binding) of
12) Confidence 0.02 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 0.23 Pain Relevance 0
CONCLUSIONS: The findings suggested that the use of protein-binding competitive inhibitors would be effective in improving the pharmacokinetics of radiopharmaceuticals with high affinity for serum protein.


serum protein Binding (affinity) of
13) Confidence 0.01 Published 2009 Journal Eur. J. Nucl. Med. Mol. Imaging Section Body Doc Link 18709369 Disease Relevance 0 Pain Relevance 0
We assumed competitive inhibitors of protein binding to be useful for procuring a favorable biodistribution of (186)Re-MAG3-HBP for the palliation of bone pain because it has been reported that the concurrent administration of (99m)Tc-MAG3 and drugs with high affinity for serum protein produced competitive displacement at specific binding sites and enhanced total clearance and tissue distribution.
serum protein Binding (affinity) of associated with pain
14) Confidence 0.01 Published 2009 Journal Eur. J. Nucl. Med. Mol. Imaging Section Abstract Doc Link 18709369 Disease Relevance 0.26 Pain Relevance 0.26
It was suggested that APAPS has not only the displacing activity of serum protein binding but also other specific effectiveness on the distribution of APAP.
serum protein Binding (binding) of associated with paracetamol
15) Confidence 0.01 Published 1997 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9178933 Disease Relevance 0 Pain Relevance 0.97
Differential effect of cancer on the serum protein binding to mianserin and imipramine.
serum protein Binding (binding) of associated with cancer
16) Confidence 0.01 Published 1995 Journal Eur J Drug Metab Pharmacokinet Section Title Doc Link 8582434 Disease Relevance 0.47 Pain Relevance 0.03
Postburn serum drug binding and serum protein concentrations.
serum protein Binding (binding) of
17) Confidence 0.00 Published 1986 Journal J Clin Pharmacol Section Title Doc Link 3950058 Disease Relevance 0.41 Pain Relevance 0.27
Alpha 1-acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome.
serum protein Binding (binding) of associated with syndrome, methadone and abstinence syndrome
18) Confidence 0.00 Published 2000 Journal Int J Clin Pharmacol Ther Section Title Doc Link 10667835 Disease Relevance 0.10 Pain Relevance 0.24

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