INT98965

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Context Info
Confidence 0.00
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CFHR4)
Anatomy Link Frequency
SK-N-SH 2
CFHR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 2 96.94 Very High Very High Very High
mu opioid receptor 12 95.52 Very High Very High Very High
narcan 2 89.96 High High
antagonist 2 89.56 High High
agonist 2 86.24 High High
Enkephalin 2 84.92 Quite High
Analgesic 2 84.84 Quite High
Morphine 4 84.36 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examined DNA-protein interactions in the human MOR (hMOR) -500 to -292 promoter region, and tested whether chronic opioid drug treatment could modulate these DNA-protein interactions. 5'-deletion and transient transfection assays in SK-N-SH cells revealed four regions that activated hMOR gene transcription.
Positive_regulation (activated) of Transcription (transcription) of hMOR gene in SK-N-SH associated with mu opioid receptor and opioid
1) Confidence 0.00 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.52
Such enhanced binding of Sp1/Sp3 to the promoter may lead to a functional change in hMOR gene transcription.
Positive_regulation (change) of Transcription (transcription) of hMOR gene
2) Confidence 0.00 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.31

General Comments

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