INT98975

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.40
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) aging (Hmgcr) endoplasmic reticulum (Hmgcr)
embryo development (Hmgcr)
Anatomy Link Frequency
body 1
Hmgcr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 7 93.68 High High
Serotonin 6 90.32 High High
Dopamine 8 85.76 High High
noradrenaline 5 84.96 Quite High
Morphine 6 83.60 Quite High
Neurotransmitter 6 78.72 Quite High
agonist 2 52.32 Quite High
spastic colon 2 50.00 Quite Low
nMDA receptor 1 25.00 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 10 99.84 Very High Very High Very High
Autism 9 99.48 Very High Very High Very High
Obesity 10 99.20 Very High Very High Very High
Disease 13 96.52 Very High Very High Very High
Down Syndrome 4 95.52 Very High Very High Very High
Body Weight 12 88.88 High High
Disorder Of Lipid Metabolism 44 87.52 High High
Peripheral Arterial Disease 10 86.40 High High
Handedness 2 85.28 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane Na+-K+ ATPase activity, serum magnesium and ubiquinone were decreased while HMG CoA reductase activity, serum digoxin and dolichol levels were increased in both the disorders.
Positive_regulation (increased) of HMG CoA reductase
1) Confidence 0.16 Published 2002 Journal Neurol India Section Abstract Doc Link 12134182 Disease Relevance 0.50 Pain Relevance 0.26
The results showed that all right hemispheric dominant individuals and 50% of left hemispheric dominant individuals had increased HMG CoA reductase activity, elevated digoxin and dolichol levels.
Positive_regulation (increased) of HMG CoA reductase
2) Confidence 0.16 Published 2003 Journal Int. J. Neurosci. Section Abstract Doc Link 12881188 Disease Relevance 0.09 Pain Relevance 0.28
The HMG-CoA reductase activity was increased in HFD fed animals significantly (P<0.001) and was reduced by MEEV 400 mg/kg significantly (P<0.001).
Positive_regulation (increased) of HMG-CoA reductase
3) Confidence 0.11 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Abstract Doc Link PMC2996074 Disease Relevance 0.42 Pain Relevance 0
There was a significant (P<0.001) increase in the HMG-CoA reductase activity in the group II animals indicating increased cholesterol synthesis.
Positive_regulation (increase) of HMG-CoA reductase
4) Confidence 0.11 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.34 Pain Relevance 0
In individuals with high body mass index an upregulated isoprenoid pathway with increased HMG CoA reductase activity, serum digoxin and dolichol levels and low ubiquinone levels were observed.
Positive_regulation (increased) of HMG CoA reductase in body associated with obesity
5) Confidence 0.09 Published 2002 Journal Neurol India Section Abstract Doc Link 12577094 Disease Relevance 0.68 Pain Relevance 0.20
Membrane Na+-K+ ATPase activity and serum magnesium levels were decreased while HMG CoA reductase activity and serum digoxin levels were increased in myalgic encephalomyelitis (ME).
Positive_regulation (increased) of HMG CoA reductase associated with chronic fatigue syndrome
6) Confidence 0.09 Published 2003 Journal Int. J. Neurosci. Section Abstract Doc Link 12745627 Disease Relevance 0.70 Pain Relevance 0.26
RESULTS: The isoprenoid pathway was upregulated in IBS, with increased HMG CoA reductase activity (0.8 [0.07] vs 0.4 [0.06] in controls; p<0.01), serum digoxin (14.8 [1.0] vs 29.0 [1.2] ng/dL; p<0.01) and dolichol levels (63.8 [3.0] vs 120.3 [3.6] mg/dL; p<0.01).
Positive_regulation (increased) of HMG CoA reductase
7) Confidence 0.06 Published 2001 Journal Indian J Gastroenterol Section Body Doc Link 11676326 Disease Relevance 0.08 Pain Relevance 0
There was an upregulation of the isoprenoid pathway as evidenced by elevated HMG CoA reductase activity in autism.
Positive_regulation (elevated) of HMG CoA reductase associated with autism
8) Confidence 0.03 Published 2003 Journal Int. J. Neurosci. Section Abstract Doc Link 14585753 Disease Relevance 0.51 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox