INT98976

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.71
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
blood 1
vessels 1
smooth muscle cell 1
frontal cortex 1
F2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
anesthesia 5 100.00 Very High Very High Very High
Nucleus accumbens 2 100.00 Very High Very High Very High
antagonist 9 99.96 Very High Very High Very High
agonist 12 87.44 High High
Glutamate 1 84.24 Quite High
Inflammation 46 83.24 Quite High
cytokine 12 80.64 Quite High
Hippocampus 3 75.00 Quite High
lidocaine 18 72.08 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 99.28 Very High Very High Very High
INFLAMMATION 54 83.24 Quite High
Stress 9 61.48 Quite High
Coagulation Disorder 4 51.60 Quite High
Dysmenorrhea 2 50.00 Quite Low
Cancer 9 40.68 Quite Low
Cystitis 8 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Interstitial Cystitis 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Much higher temperatures and longer heating times are needed to abolish the activity of endotoxin [31], [32], therefore it is highly unlikely that our heating conditions affected the activity of the small amount (14 EU/g thrombin) of endotoxin present.
Regulation (affected) of thrombin
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Effects of a new PAR1 antagonist, F 16618, on smooth muscle cell contraction.
Regulation (Effects) of PAR1 in smooth muscle cell associated with anesthesia and antagonist
2) Confidence 0.45 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19344702 Disease Relevance 0 Pain Relevance 0.27
This study evaluated the effects of two PAR1 antagonists on vessels contracted by SFLLR.
Regulation (effects) of PAR1 in vessels associated with antagonist
3) Confidence 0.45 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19344702 Disease Relevance 0 Pain Relevance 0.15
The effect of thrombin stimulation (100 nM) on urothelial MIF release was examined in UROtsa cells (in vitro) and in rats (in vivo).
Spec (examined) Regulation (effect) of thrombin
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013117 Disease Relevance 0.24 Pain Relevance 0.28
We studied the effects of self-administered (SA) vs. experimenter-administered (EA) morphine on dendritic spines in the hippocampal formation (CA1 and dentate), nucleus accumbens shell (NAcc-s), sensory cortex (Par1 and Oc1), medial frontal cortex (Cg3), and orbital frontal cortex (AID) of rats.
Regulation (effects) of Par1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy and morphine
5) Confidence 0.42 Published 2002 Journal Synapse Section Abstract Doc Link 12373743 Disease Relevance 0.35 Pain Relevance 0.44
In vivo contraction studies further confirmed that indomethacin (2 mg/kg) pretreatment had no effect on blood- or thrombin-stimulated contractile activity.
Neg (no) Regulation (effect) of thrombin-stimulated in blood
6) Confidence 0.27 Published 2001 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 11677145 Disease Relevance 0 Pain Relevance 0
Despite the suppression of PGF2alpha production, pretreatment with indomethacin had no inhibitory effect on thrombin-stimulated contractile activity.
Neg (no) Regulation (effect) of thrombin-stimulated
7) Confidence 0.27 Published 2001 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 11677145 Disease Relevance 0.05 Pain Relevance 0
The HFG male unique up-regulated pathways showed a strong presence of certain physiological functions, i.e. energy regulation/metabolism (Bile_acid, Butanoate, FA biosynth, Glyoxylate, KET, Propanoate, electronstranport, etc, glycolysis), immune regulation (par1, tob1), cell signaling (akap96, akapCentrosome) and steroid receptor activity (ANDROGEN, mta3).
Regulation (regulation) of par1
8) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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