INT9898

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 4.47
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
leukocyte 4
endothelial cells 3
blood 2
plasma 2
vessels 2
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 3 96.36 Very High Very High Very High
epidural 3 96.00 Very High Very High Very High
Angina 13 90.80 High High
Potency 3 77.56 Quite High
Neuropeptide 105 50.00 Quite Low
adenocard 6 36.00 Quite Low
Inflammation 27 5.00 Very Low Very Low Very Low
tolerance 20 5.00 Very Low Very Low Very Low
Intracerebroventricular 9 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 37 99.96 Very High Very High Very High
Myocardial Infarction 11 99.90 Very High Very High Very High
Atherosclerosis 37 99.40 Very High Very High Very High
Disease 6 98.48 Very High Very High Very High
Congenital Anomalies 6 97.12 Very High Very High Very High
Renal Disease 4 96.04 Very High Very High Very High
Acute Coronary Syndrome 6 95.36 Very High Very High Very High
Cardiovascular Disease 39 94.72 High High
Diabetes Mellitus 265 92.84 High High
Infarction 2 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Positive_regulation (increased) of Gene_expression (levels) of von Willebrand factor in blood associated with increased venous pressure under development
1) Confidence 0.49 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.61 Pain Relevance 0
vWf is widely used as a marker of vessels in all kinds of archival tissues, however expression of vWf depends on the fuctional status of the endothelium [20] and also varies with different sized vessels.
Positive_regulation (depends) of Gene_expression (expression) of vWf in vessels
2) Confidence 0.44 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576503 Disease Relevance 0.19 Pain Relevance 0
To determine the amount of protein secreted into the medium of 293T cells transfected with flAgRP, VWF-AgRP83-132 and GFP a spot blot was performed.
Positive_regulation (transfected) of Gene_expression (transfected) of VWF-AgRP83-132
3) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0
Supernatants of both constructs activated the MC4R, with the polymeric VWF-?
Positive_regulation (Supernatants) of Gene_expression (with) of VWF
4) Confidence 0.32 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0.06 Pain Relevance 0
Medium from cells transfected with AAV-VWF-?
Positive_regulation (transfected) of Gene_expression (transfected) of AAV-VWF
5) Confidence 0.32 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.04
CONCLUSIONS: These data suggest that elevated plasma levels of t-PA and vWF may correlate with instability of atheromatous plaques, and that their decrease after coronary interventions may reflect plaque reendothelialization and stabilization.


Positive_regulation (elevated) of Gene_expression (levels) of vWF in plasma
6) Confidence 0.19 Published 1997 Journal J. Am. Coll. Cardiol. Section Body Doc Link 9350928 Disease Relevance 0 Pain Relevance 0
However, in type 1, the increased synthesis of von Willebrand factor (vWF) and factor VIII (FVIII:C) during pregnancy can lead to a correction of biological abnormalities and may allow epidural analgesia to be performed for delivery.
Positive_regulation (increased) of Gene_expression (synthesis) of vWF associated with congenital anomalies, epidural and analgesia
7) Confidence 0.15 Published 2007 Journal Int J Obstet Anesth Section Abstract Doc Link 17509867 Disease Relevance 0.27 Pain Relevance 0.40
There was a statistically significant correlation between transmural myocardial infarction and increased levels of fibrinogen, von Willebrand factor and white blood cells.
Positive_regulation (increased) of Gene_expression (levels) of von Willebrand factor in white blood cells associated with myocardial infarction
8) Confidence 0.08 Published 1992 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 1443785 Disease Relevance 0.63 Pain Relevance 0.27
Thus, the observed increases in vWF, platelet expression of CD40L, and platelet-leukocyte conjugates are consistent with platelet activation in response to UFP exposure.
Positive_regulation (increases) of Gene_expression (expression) of vWF in leukocyte
9) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.58 Pain Relevance 0
For example, increased plasma levels of vWF, which can be released by both vascular endothelial cells and platelets, have been linked to endothelial dysfunction and increased cardiovascular disease risk (Lee et al. 2005; Roldán et al. 2005; Zareba et al. 2001).
Positive_regulation (increased) of Gene_expression (levels) of vWF in endothelial cells associated with cardiovascular disease
10) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.57 Pain Relevance 0
For example, increased plasma levels of vWF, which can be released by both vascular endothelial cells and platelets, have been linked to endothelial dysfunction and increased cardiovascular disease risk (Lee et al. 2005; Roldán et al. 2005; Zareba et al. 2001).
Positive_regulation (increased) of in platelets Gene_expression (levels) of vWF in endothelial cells associated with cardiovascular disease
11) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.57 Pain Relevance 0

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