INT98983

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.35
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL18R1) plasma membrane (IL18R1) intracellular (IL18R1)
Anatomy Link Frequency
neurons 1
astrocytes 1
microglia 1
IL18R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
Dismenorea 4 99.72 Very High Very High Very High
Dorsal horn 3 99.68 Very High Very High Very High
Inflammation 19 97.38 Very High Very High Very High
Brush evoked pain 6 97.00 Very High Very High Very High
spinal dorsal horn 2 95.60 Very High Very High Very High
addiction 6 94.68 High High
qutenza 1 86.92 High High
Inflammatory marker 1 82.76 Quite High
chemokine 9 79.12 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 4 99.72 Very High Very High Very High
Nervous System Injury 11 99.16 Very High Very High Very High
Mucositis 1 97.38 Very High Very High Very High
Neuropathic Pain 11 97.00 Very High Very High Very High
INFLAMMATION 19 89.20 High High
Injury 3 85.68 High High
Necrosis 1 79.36 Quite High
Cancer 1 79.00 Quite High
Nociception 9 78.12 Quite High
Hypersensitivity 2 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative competitive PCR demonstrated that endometrial IL-18R mRNA and the ratio of IL-18BP to IL-18 were significantly increased in adenomyosis patients in comparison to the control group.
Gene_expression (ratio) of IL-18R
1) Confidence 0.13 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis.
Gene_expression (expression) of IL-18R associated with dismenorea
2) Confidence 0.11 Published 2010 Journal Fertil. Steril. Section Abstract Doc Link 19394601 Disease Relevance 0.17 Pain Relevance 0.17
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Gene_expression (expression) of IL-18R in astrocytes associated with nervous system injury and dorsal horn
3) Confidence 0.06 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.68 Pain Relevance 0.51
Mucosal inflammation symptoms correlated with increased levels of albumin, but not with increased levels of ECP, secreted proinflammatory cytokines or cytokine gene mRNA expression.
Gene_expression (expression) of cytokine gene mRNA associated with mucositis, inflammation and cytokine
4) Confidence 0.04 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.53 Pain Relevance 0.46
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Gene_expression (expression) of IL-18R in microglia associated with nervous system injury and dorsal horn
5) Confidence 0.02 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.68 Pain Relevance 0.51
As in our study, acute applications did not increase Na+ current (and in fact caused slight decreases in the Na+ current), and the cytokine receptor was shown to be expressed on the neurons.
Gene_expression (expressed) of cytokine receptor in neurons associated with cytokine
6) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.22 Pain Relevance 0.58

General Comments

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