INT9899

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Context Info
Confidence 0.74
First Reported 1986
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 91
Total Number 93
Disease Relevance 45.06
Pain Relevance 9.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
plasma 18
endothelial cells 7
platelets 6
blood 5
vessels 4
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 108 100.00 Very High Very High Very High
Inflammation 336 99.98 Very High Very High Very High
Migraine 5 99.08 Very High Very High Very High
peptic ulcer disease 5 98.60 Very High Very High Very High
rheumatoid arthritis 297 98.48 Very High Very High Very High
alcohol 18 98.48 Very High Very High Very High
endometriosis 276 97.52 Very High Very High Very High
Restless leg syndrome 10 97.28 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 13 96.72 Very High Very High Very High
epidural 5 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 152 100.00 Very High Very High Very High
INFLAMMATION 380 99.98 Very High Very High Very High
Skin Cancer 47 99.90 Very High Very High Very High
Apoptosis 47 99.90 Very High Very High Very High
Disorder Of Lipid Metabolism 43 99.84 Very High Very High Very High
Vasculitis 18 99.84 Very High Very High Very High
Coagulation Disorder 9 99.84 Very High Very High Very High
Cancer 181 99.78 Very High Very High Very High
Rheumatoid Arthritis 349 99.76 Very High Very High Very High
Myocardial Infarction 189 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The different staining characteristics of larger vessels and capillaries in our study may reflect differences in vWf expression levels.
Gene_expression (expression) of vWf in vessels
1) Confidence 0.74 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576503 Disease Relevance 0 Pain Relevance 0
Blood group O and vWf expression may be involved in development of peptic ulcer disease secondary to Helicobacter pylori infection.
Gene_expression (expression) of vWf in Blood associated with peptic ulcer disease, ulcers, disease and infection
2) Confidence 0.73 Published 2009 Journal Med. Hypotheses Section Title Doc Link 19423238 Disease Relevance 1.37 Pain Relevance 0.28
The tissue sections were immunostained for von Willebrant factor (vWF) using a commercial staining kit (Chemicon, Temecula, CA, USA) and imaged by means of a Nikon Eclipse E800 light microscope and a Spot RT digital camera (Diagnostic Instruments, Sterling Heights, MI, USA).
Gene_expression (immunostained) of vWF
3) Confidence 0.65 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.09 Pain Relevance 0.08
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Gene_expression (levels) of von Willebrand factor in blood associated with increased venous pressure under development
4) Confidence 0.65 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.60 Pain Relevance 0
Similarly, in our studies of retinal sections, vWf immunostaining mainly appeared in the larger vessels of the nerve fiber layer, inner nuclear layer and outer plexiform layer, and sparsely in capillaries.
Gene_expression (immunostaining) of vWf in vessels
5) Confidence 0.64 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576503 Disease Relevance 0.11 Pain Relevance 0
INTRODUCTION: To evaluate the participation of the vessel wall in the pathogenesis of migraine attack, we measured the plasma levels of von Willebrand factor (vWF), a protein secreted from the endothelial cells.
Gene_expression (levels) of von Willebrand factor in endothelial cells associated with migraine
6) Confidence 0.59 Published 1995 Journal Acta Neurol. Scand. Section Abstract Doc Link 7639074 Disease Relevance 0.17 Pain Relevance 0.17
INTRODUCTION: To evaluate the participation of the vessel wall in the pathogenesis of migraine attack, we measured the plasma levels of von Willebrand factor (vWF), a protein secreted from the endothelial cells.
Gene_expression (levels) of vWF in endothelial cells associated with migraine
7) Confidence 0.59 Published 1995 Journal Acta Neurol. Scand. Section Abstract Doc Link 7639074 Disease Relevance 0.17 Pain Relevance 0.17
vWf is widely used as a marker of vessels in all kinds of archival tissues, however expression of vWf depends on the fuctional status of the endothelium [20] and also varies with different sized vessels.
Gene_expression (expression) of vWf in vessels
8) Confidence 0.57 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576503 Disease Relevance 0.19 Pain Relevance 0
In order to determine if this parameter may serve as a marker for AMI, we tested the blood levels of vWF and Factor VIII:C in 28 patients with AMI, 9 patients with unstable angina, 7 patients with atypical chest pain, and 25 healthy volunteers.
Gene_expression (levels) of vWF in chest associated with angina and myocardial infarction
9) Confidence 0.57 Published 1986 Journal Thromb. Haemost. Section Abstract Doc Link 3092393 Disease Relevance 0.89 Pain Relevance 0.27
Comparison of vessel labeling with gelatin-ink infusion or vWf immunostaining
Gene_expression (immunostaining) of vWf
10) Confidence 0.56 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576503 Disease Relevance 0 Pain Relevance 0
At 30 days of follow-up, delta vWf was sevenfold higher in patients with an end point (death, myocardial infarction, revascularization) than in patients free of events (+53 +/-7% vs. +7 +/-14%, p = 0.004).
Gene_expression (higher) of vWf
11) Confidence 0.52 Published 2000 Journal J. Am. Coll. Cardiol. Section Body Doc Link 10898421 Disease Relevance 0.06 Pain Relevance 0
A significant correlation between vWF and IL-6 levels, measured on admission and 7 days later, was found in patients with UA (r=+0.74 and r=+0.55, respectively).
Gene_expression (levels) of vWF
12) Confidence 0.50 Published 2004 Journal Kardiol Pol Section Body Doc Link 15457277 Disease Relevance 0.12 Pain Relevance 0
AIM: To examine the correlation between the IL-1beta, IL-6 and vWF levels in patients with ACS.
Gene_expression (levels) of vWF
13) Confidence 0.50 Published 2004 Journal Kardiol Pol Section Body Doc Link 15457277 Disease Relevance 0.19 Pain Relevance 0
The PCR fragment was subsequently digested with AgeI and EcoRI and ligated into AgeI- EcoRI digested pCMV-VWF-?
Gene_expression (digested) of VWF
14) Confidence 0.50 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.11
To determine the amount of protein secreted into the medium of 293T cells transfected with flAgRP, VWF-AgRP83-132 and GFP a spot blot was performed.
Gene_expression (transfected) of VWF-AgRP83-132
15) Confidence 0.50 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0
Detection of von Willebrand factor and tissue factor in platelets-fibrin rich coronary thrombi in acute myocardial infarction.
Gene_expression (Detection) of von Willebrand factor in platelets associated with myocardial infarction
16) Confidence 0.48 Published 2006 Journal Am. J. Cardiol. Section Title Doc Link 16377278 Disease Relevance 0.44 Pain Relevance 0.08
After consultation with the hematologist well ahead of the conception, appropriate laboratory workup including clotting factor levels including FVIII, vWF:RcoF, vWF:Ag on different occasions peripartum, and provision of adequate prophylactic medical treatment, she underwent Cesarean section under epidural anesthesia without neurological or bleeding complications. von Willebrand disease is the most common inherited bleeding disorder that may result in various bleeding complications in a parturient as a result of hemostatic challenges during pregnancy.
Gene_expression (levels) of vWF associated with coagulation disorder, anesthesia, epidural, hemorrhage and disease
17) Confidence 0.48 Published 2009 Journal J Ark Med Soc Section Abstract Doc Link 19475813 Disease Relevance 0.80 Pain Relevance 0.38
Medium from cells transfected with AAV-VWF-?
Gene_expression (transfected) of AAV-VWF
18) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.04
To check if monomeric VWF-?
Gene_expression (check) of VWF
19) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0
Supernatants of both constructs activated the MC4R, with the polymeric VWF-?
Gene_expression (with) of VWF
20) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0.06 Pain Relevance 0

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