INT98992

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 12.97
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
endothelial cells 2
monocyte 2
endothelium 2
macrophages 1
leukocyte 1
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 111 99.12 Very High Very High Very High
cytokine 16 98.08 Very High Very High Very High
addiction 3 90.32 High High
Inflammatory marker 1 81.76 Quite High
chemokine 15 81.44 Quite High
Bioavailability 5 81.32 Quite High
Spinal cord 1 81.12 Quite High
Pain 1 81.00 Quite High
imagery 12 70.24 Quite High
tolerance 5 65.04 Quite High
Disease Link Frequency Relevance Heat
Adhesions 141 100.00 Very High Very High Very High
Atherosclerosis 38 99.84 Very High Very High Very High
INFLAMMATION 142 99.12 Very High Very High Very High
Disease 41 98.88 Very High Very High Very High
Stress 43 98.68 Very High Very High Very High
Diabetes Mellitus 87 96.96 Very High Very High Very High
Critical Illness 1 96.56 Very High Very High Very High
Necrosis 12 95.80 Very High Very High Very High
Cancer 165 95.44 Very High Very High Very High
Peripheral Arterial Disease 3 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that P-selectin, PSGL-1, VLA-4 and VCAM-1 are the most important adhesion molecules involved in monocyte recruitment to atherosclerotic lesions.
VCAM-1 Binding (recruitment) of in monocyte associated with atherosclerosis and adhesions
1) Confidence 0.34 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 0.96 Pain Relevance 0.08
VCAM-1 binds monocytes and T lymphocytes, the first step of invasion of the vessel wall by inflammatory cells (Libby 2002).
VCAM-1 Binding (binds) of in T lymphocytes associated with inflammation
2) Confidence 0.30 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.99 Pain Relevance 0.17
9-integrin, which both bind VCAM-1, and could possibly, play an important role in neutrophil extravasation at sites of inflammation [36].
VCAM-1 Binding (bind) of in neutrophil associated with inflammation
3) Confidence 0.20 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.03 Pain Relevance 0.12
More recently, cytokines (e.g., interleukin-6) and soluble adhesion molecules (e.g., intercellular adhesion molecule-1, vascular cell adhesion molecule-1) have been associated with both risk factors and disease [3].
vascular cell adhesion molecule-1 Binding (associated) of associated with disease, adhesions and cytokine
4) Confidence 0.20 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 1.39 Pain Relevance 0.13
A VHSPNKK-modified magnetofluorescent nanoparticle (VNP) demonstrated high affinity for VCAM-1-expressing endothelial cells but very low affinity for macrophages.
VCAM-1-expressing Binding (affinity) of in macrophages
5) Confidence 0.14 Published 2006 Journal Int J Pept Res Ther Section Body Doc Link PMC2678933 Disease Relevance 0.95 Pain Relevance 0.11
One specific sequence (VHSPNKK) having homology to the alpha-chain of very late antigen (a known ligand for VCAM-1) bound VCAM-1 and interfered with leukocyte-endothelial interactions.
VCAM-1 Binding (ligand) of in leukocyte
6) Confidence 0.14 Published 2006 Journal Int J Pept Res Ther Section Body Doc Link PMC2678933 Disease Relevance 0.85 Pain Relevance 0.03
VCAM-1 binds monocytes and T lymphocytes, the first step of invasion of the vessel wall by inflammatory cells (Libby 2002).
VCAM-1 Binding (binds) of in monocytes associated with inflammation
7) Confidence 0.10 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.99 Pain Relevance 0.17
Moreover the investigators measured plasma concentrations of ET-1, soluble intercellular adhesion molecule (sICAM), and soluble vascular cell adhesion molecule (sVCAM), as indicators of endothelial cells activation.
vascular cell adhesion molecule Binding (concentrations) of in endothelial cells associated with adhesions
8) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 1.33 Pain Relevance 0.03
Moreover the investigators measured plasma concentrations of ET-1, soluble intercellular adhesion molecule (sICAM), and soluble vascular cell adhesion molecule (sVCAM), as indicators of endothelial cells activation.
sVCAM Binding (concentrations) of in endothelial cells associated with adhesions
9) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 1.33 Pain Relevance 0.03
Herein, the authors show that in a mouse model of HSC transplantation, SDF-1 was not required for stem cell homing due to compensatory action via the VLA-4/VCAM-1 interaction [31].
VCAM-1 Binding (interaction) of in stem cell
10) Confidence 0.10 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.20 Pain Relevance 0.04
The adhesion molecules VCAM-1 and ICAM-1 facilitate interaction between sickle RBCs and WBCs and the endothelium, thereby promoting vaso-occlusion.
VCAM-1 Binding (interaction) of in endothelium associated with adhesions
11) Confidence 0.10 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.01 Pain Relevance 0
B activity are those that encode the adhesion molecules VCAM-1 and ICAM-1, which can facilitate binding of sickle RBCs and WBCs to the endothelium.
VCAM-1 Binding (binding) of in endothelium associated with adhesions
12) Confidence 0.10 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.63 Pain Relevance 0
Shear stress varied from 1.0 dyne/cm 2 (microvascular venular flow), in which VCAM-1 ligand interactions induced by TNF-alpha primarily controlled adherence, to 0.1 dyne/cm 2 (low flow), in which stimulation had little effect on adherence.
VCAM-1 Binding (interactions) of associated with stress
13) Confidence 0.06 Published 2004 Journal J. Lab. Clin. Med. Section Abstract Doc Link 15570244 Disease Relevance 1.18 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox