INT98996

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.09
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2)
Anatomy Link Frequency
endothelial cells 1
Itgb2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 98.80 Very High Very High Very High
Angina 1 93.68 High High
Inflammation 5 93.16 High High
antagonist 7 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
Desipramine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 3 97.48 Very High Very High Very High
Adhesions 10 97.44 Very High Very High Very High
Atherosclerosis 7 94.88 High High
Autoimmune Disease 3 94.12 High High
Cv General 3 Under Development 1 93.68 High High
INFLAMMATION 5 93.16 High High
Immune System Diseases 1 92.00 High High
Infection 1 80.24 Quite High
Vasculitis 1 61.76 Quite High
Targeted Disruption 6 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with other integrins, the functional activity of LFA-1 is controlled by a form of intracellular signaling, termed ‘inside-out’ signaling [5], [6].
Regulation (controlled) of LFA-1
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.72 Pain Relevance 0.09
Reconstituted in vitro systems using monocytes on cytokine-activated endothelial cells under shear flow suggested the involvement of P-selectin, L-selectin, VCAM-1, its ligand, VLA-4 integrin and CD18 integrins.
Regulation (involvement) of CD18 in endothelial cells associated with cytokine
2) Confidence 0.24 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.37 Pain Relevance 0.18

General Comments

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