INT99000

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.26
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga1)
Anatomy Link Frequency
leukocyte 1
monocyte 1
stem cell 1
Itga1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 23 96.60 Very High Very High Very High
Arthritis 112 95.28 Very High Very High Very High
rheumatoid arthritis 13 84.64 Quite High
chemokine 10 81.68 Quite High
cytokine 36 75.44 Quite High
Angina 1 52.48 Quite High
tolerance 1 11.84 Low Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 23 100.00 Very High Very High Very High
Atherosclerosis 7 99.84 Very High Very High Very High
Arthritis 127 96.84 Very High Very High Very High
Rheumatoid Arthritis 13 84.64 Quite High
Vasculitis 1 81.80 Quite High
Injury 25 80.20 Quite High
Disease 10 54.00 Quite High
Cv General 3 Under Development 1 52.48 Quite High
Immunization 8 44.92 Quite Low
INFLAMMATION 22 28.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that P-selectin, PSGL-1, VLA-4 and VCAM-1 are the most important adhesion molecules involved in monocyte recruitment to atherosclerotic lesions.
VLA-4 Binding (recruitment) of in monocyte associated with atherosclerosis and adhesions
1) Confidence 0.06 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 0.97 Pain Relevance 0.08
Support for this model comes from studies showing loss or inhibition of CD44 and VLA-4 (very late antigen-4) interactions with their ligands that can reduce leukocyte rolling interactions and inhibit joint inflammation in animal models of arthritis [19,20].
VLA-4 Binding (interactions) of in leukocyte associated with inflammation and arthritis
2) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.09 Pain Relevance 0.46
Herein, the authors show that in a mouse model of HSC transplantation, SDF-1 was not required for stem cell homing due to compensatory action via the VLA-4/VCAM-1 interaction [31].
VLA-4 Binding (interaction) of in stem cell
3) Confidence 0.02 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.20 Pain Relevance 0.04

General Comments

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