INT99001

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 16.68
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelets 2
joints 2
endothelial cells 2
liver 1
leukocytes 1
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 560 99.76 Very High Very High Very High
Inflammation 247 99.46 Very High Very High Very High
Inflammatory response 91 99.32 Very High Very High Very High
cytokine 267 98.96 Very High Very High Very High
rheumatoid arthritis 65 98.84 Very High Very High Very High
Pain 1 98.80 Very High Very High Very High
cINOD 11 97.80 Very High Very High Very High
chemokine 149 97.44 Very High Very High Very High
tolerance 5 94.24 High High
ischemia 71 93.12 High High
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 4 99.80 Very High Very High Very High
Arthritis 635 99.76 Very High Very High Very High
INFLAMMATION 323 99.46 Very High Very High Very High
Congenital Anomalies 3 99.34 Very High Very High Very High
Immunization 40 99.28 Very High Very High Very High
Atherosclerosis 7 98.88 Very High Very High Very High
Rheumatoid Arthritis 65 98.84 Very High Very High Very High
Asthma 6 98.76 Very High Very High Very High
Adhesions 310 98.42 Very High Very High Very High
Injury 429 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As P-selectin is a promising target for anti-inflammatory approaches, we focused on P-selectin inhibition by other sulfated polysaccharides and compared them with six heparins.
Negative_regulation (inhibition) of P-selectin associated with inflammation
1) Confidence 0.59 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16780802 Disease Relevance 0.19 Pain Relevance 0.09
To check the P-selectin inhibition in vivo, heparin and one phycarin sulfate were tested using intravital microscopy of microvasculature in mice.
Negative_regulation (inhibition) of P-selectin
2) Confidence 0.43 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16780802 Disease Relevance 0.06 Pain Relevance 0.10
We conclude that endothelial cell P-selectin contributes to the microcirculatory abnormalities in sickle cell disease and that blocking P-selectin may be useful for preventing painful vasoocclusion in sickle cell disease.
Negative_regulation (blocking) of P-selectin in endothelial cell associated with sickle cell anemia, pain and congenital anomalies
3) Confidence 0.43 Published 2004 Journal Blood Section Abstract Doc Link 15271798 Disease Relevance 0.63 Pain Relevance 0.22
Our study indicates that semisynthetic glucan sulfates with optimal structures block P-selectin excellently and might become promising candidates for anti-inflammatory drugs to replace heparin for certain applications.
Negative_regulation (block) of P-selectin associated with inflammation and cinod
4) Confidence 0.43 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16780802 Disease Relevance 0.10 Pain Relevance 0.10
Both compounds significantly reduced the rolling fractions of activated platelets on endothelium as effective as a blocking P-selectin antibody.
Negative_regulation (blocking) of P-selectin in endothelium
5) Confidence 0.43 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16780802 Disease Relevance 0 Pain Relevance 0.09
This may be explained by a limit on how quickly a mouse can actually develop CIA, even with loss of both E-selectin and P-selectin.
Negative_regulation (loss) of P-selectin associated with arthritis
6) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.08 Pain Relevance 0.56
This would result in the observed elevated monokine production in mice lacking E-selectin and P-selectin.
Negative_regulation (lacking) of P-selectin
7) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.81 Pain Relevance 0.43
Therefore, we investigated whether the loss of E-selectin or P-selectin affected the expression levels of five different cytokines and chemokines that are implicated in the development of CIA.
Spec (whether) Negative_regulation (loss) of P-selectin associated with chemokine, arthritis and cytokine
8) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.06 Pain Relevance 0.60
Nevertheless, local activation might have occurred, possibly explaining the reduced number of P-selectin-expressing platelets during the second week.
Spec (possibly) Negative_regulation (reduced) of P-selectin in platelets
9) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.47 Pain Relevance 0.03
In this context, we suggest that reduced P-selectin-positive platelets in the face of signs of cerebral worsening reflect functional disturbance of the isolated platelets, assuming that platelets contribute to pathophysiologic cascades within the injured brain in these patients.
Negative_regulation (reduced) of P-selectin in platelets
10) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.06 Pain Relevance 0
As discussed below, there are a number of possible explanations as to why P-selectin and ICAM-1 deficiency did not appear to be critical for neutrophil infiltration and hepatocellular injury following liver I/R.
Negative_regulation (deficiency) of P-selectin in liver associated with injury
11) Confidence 0.36 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.98 Pain Relevance 0.09
Consistent with these findings, apoE-/- mice that are also deficient for P-selectin show significantly reduced atherosclerotic lesion sizes and are almost completely protected from neointimal growth after vascular injury.
Negative_regulation (deficient) of P-selectin associated with atherosclerosis and vasculitis
12) Confidence 0.30 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.34 Pain Relevance 0.14
Previously, we showed that P-selectin deficiency in mice resulted in accelerated onset of joint inflammation in the murine collagen-immunized arthritis model.
Negative_regulation (deficiency) of P-selectin in joint associated with inflammation and arthritis
13) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257424 Disease Relevance 0.79 Pain Relevance 0.36
Therefore, mice lacking both E-selectin and P-selectin are seemingly primed to mount a robust inflammatory response in their joints.
Negative_regulation (lacking) of P-selectin in joints associated with inflammatory response
14) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.91 Pain Relevance 0.47
Verification of ICAM-1 and P-selectin deficiency in P/I null mice
Negative_regulation (deficiency) of P-selectin
15) Confidence 0.27 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.09 Pain Relevance 0
Functional redundancy of adhesion molecules and the cytokine production may be sufficient to compensate for the absence of P-selectin and ICAM-1 in mediating neutrophil infiltration into peritoneal cavity in response to CLP in P/I null mice.
Negative_regulation (absence) of P-selectin in peritoneal cavity associated with adhesions and cytokine
16) Confidence 0.27 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 1.06 Pain Relevance 0.11
In support of our data, several studies have shown that blocking of P-selectin with monoclonal antibody or deletion of P-selectin and ICAM-1 did not inhibit neutrophil infiltration and tissue injury caused by hepatic reperfusion [18], endotoxin shock (46), i.p injection of 2% glycogen [47], and intestinal inflammation [48,49].
Negative_regulation (blocking) of P-selectin in neutrophil associated with inflammation, cv general 2 under development and injury
17) Confidence 0.27 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.93 Pain Relevance 0.21
A previously published study demonstrated that P-selectin inhibition improved the survival of mice subjected to warm intestinal I/R, in which T lymphocytes (with Th2 profile) played a central role [47].
Negative_regulation (inhibition) of P-selectin in T lymphocytes
18) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.88 Pain Relevance 0.15
Gene-targeted double mutant mice deficient in P-selectin and ICAM-1 (P/I double mutant), C57BL/6-Icam1tm1BaySelptm1Bay, were used in this study.
Negative_regulation (deficient) of P-selectin
19) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.50 Pain Relevance 0.03
Blocking alpha4-integrin, P-selectin, or L-selectin had no significant effect on sinusoidal or postsinusoidal adhesion.
Negative_regulation (Blocking) of P-selectin associated with adhesions
20) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.52 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox