INT99003

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.91
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
endothelial cells 2
platelet 1
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 40 100.00 Very High Very High Very High
cytokine 14 99.92 Very High Very High Very High
Bioavailability 3 99.84 Very High Very High Very High
ischemia 2 99.42 Very High Very High Very High
Angina 7 93.68 High High
Inflammation 58 91.64 High High
Neurotransmitter 2 91.28 High High
bradykinin 11 77.92 Quite High
cva 2 72.72 Quite High
Inflammatory response 10 17.12 Low Low
Disease Link Frequency Relevance Heat
Adhesions 48 100.00 Very High Very High Very High
Reperfusion Injury 1 99.80 Very High Very High Very High
Alzheimer's Dementia 1 99.64 Very High Very High Very High
Cv Unclassified Under Development 1 99.42 Very High Very High Very High
Increased Venous Pressure Under Development 46 97.02 Very High Very High Very High
Diabetes Mellitus 62 95.24 Very High Very High Very High
Disease 13 95.20 Very High Very High Very High
Atherosclerosis 44 94.88 High High
Chronic Renal Failure 1 94.68 High High
Hemolysis 16 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reconstituted in vitro systems using monocytes on cytokine-activated endothelial cells under shear flow suggested the involvement of P-selectin, L-selectin, VCAM-1, its ligand, VLA-4 integrin and CD18 integrins.
Regulation (involvement) of VCAM-1 in endothelial cells associated with cytokine
1) Confidence 0.41 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.35 Pain Relevance 0.18
Low NO bioavailability can up-regulate VCAM-1 in the endothelial cell layer via induction of NF-?
Regulation (regulate) of VCAM-1 in endothelial cell associated with bioavailability
2) Confidence 0.28 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.05 Pain Relevance 0.18
Not only does NO maintain vasodilation by activating cGMP-dependent protein kinases, but it also inhibits platelet aggregation and attachment, limits ischemia-reperfusion injury and down-regulates adhesion molecules such as vascular cell adhesion molecule, selectins, and the potent vasoconstrictor endothelin-1 [9].
Regulation (regulates) of vascular cell adhesion molecule in platelet associated with reperfusion injury, ischemia, increased venous pressure under development and adhesions
3) Confidence 0.13 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 1.57 Pain Relevance 0.12
Marked alterations in expressio n of immunomodulator mRNA, including C-C chemokine RANTES, C-C chemokine receptors CCR1, CCR3 and CCR5, adhesion molecules PECAM-1, ICAM-1, and VCAM-1, cytokines IF N-gamma, TNF-alpha, IL-12, IL-4, and iNOS were observed to be up-regulated, while growth factors, GDF-2 and TGF-beta precursor, were down-regulated (Table 2, P < 0.05) at peak parasitaemia.


Regulation (alterations) of VCAM-1 associated with chemokine, adhesions and cytokine
4) Confidence 0.09 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.13 Pain Relevance 0.23
There was no treatment effect on the other biomarkers (ICAM, VCAM, E-selectin, trasforming growth factor-?
Neg (no) Regulation (effect) of VCAM
5) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.97 Pain Relevance 0.24
There were no significant UFP effects on soluble C-reactive protein (CRP) (Figure 2D), E-selectin, L-selectin, CD62P, intercellular cell adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1), serum amyloid A (SAA), or the coagulation markers (D-dimer, Factors VII and IX) [see Supplemental Material, Table 6 (doi:10.1289/ehp.1002237)].


Neg (no) Regulation (effects) of VCAM-1 associated with alzheimer's dementia and adhesions
6) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.37 Pain Relevance 0
Another study of DHT (dihydrotestosterone) treatment in 33 men with partial androgen deficiency also reported no changes in either CRP, sICAM-1 or sVCAM-1 serum levels [42].
Neg (no) Regulation (changes) of sVCAM-1
7) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2693125 Disease Relevance 0.46 Pain Relevance 0.09

General Comments

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