INT99004

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Context Info
Confidence 0.33
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.29
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
joint 1
aorta 1
endothelial cells 1
monocyte 1
lymphocytes 1
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 113 99.62 Very High Very High Very High
cytokine 29 97.10 Very High Very High Very High
cINOD 13 95.92 Very High Very High Very High
Inflammatory mediators 9 94.50 High High
rheumatoid arthritis 75 89.60 High High
Inflammatory response 6 88.60 High High
chemokine 20 75.24 Quite High
Arthritis 21 71.80 Quite High
Osteoarthritis 41 65.84 Quite High
metalloproteinase 19 63.92 Quite High
Disease Link Frequency Relevance Heat
Adhesions 78 100.00 Very High Very High Very High
Diabetes Mellitus 9 99.68 Very High Very High Very High
INFLAMMATION 127 99.62 Very High Very High Very High
Atherosclerosis 62 99.60 Very High Very High Very High
Rheumatoid Arthritis 117 96.48 Very High Very High Very High
Renal Disease 1 96.00 Very High Very High Very High
Vasculitis 11 89.60 High High
Disease 30 86.40 High High
Hypertension 35 85.72 High High
Disorder Of Lipid Metabolism 143 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficiency of VCAM-1 has been shown to diminish the formation of early foam cell lesions throughout the aorta of low-density lipoprotein receptor-deficient (LDLR?
Negative_regulation (Deficiency) of VCAM-1 in aorta
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.73 Pain Relevance 0.03
Interaction of monocytes with endothelial cells is mediated by adhesion molecules located on the surface of these cells, which include VCAM-1, ICAM-1, and E-selectin.
Negative_regulation (include) of VCAM-1 in endothelial cells associated with adhesions
2) Confidence 0.26 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.09 Pain Relevance 0.18
The accumulation of lymphocytes in liver sinusoids (devoid of E/P-selectins, PECAM, CD34, and VE-cadherin, and low in VCAM-1) appears to result from mechanisms distinct from those involved in multistep extravasation of intravascular lymphocytes [14].
Negative_regulation (low) of VCAM-1 in lymphocytes
3) Confidence 0.18 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.32 Pain Relevance 0.04
Transient blockade of the VLA-4/VCAM-1 adhesion pathway by antibodies or peptides in apoE-/- or LDLR-/- mice reduced monocyte and lipid accumulation in lesions.
Negative_regulation (blockade) of VCAM-1 in monocyte associated with adhesions
4) Confidence 0.17 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.02 Pain Relevance 0.09
In type 2 diabetic patients, ARBs diminished VCAM-1, whereas ACE inhibitors reduced ICAM-1 (Guba et al 2000).
Negative_regulation (diminished) of VCAM associated with diabetes mellitus
5) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.21 Pain Relevance 0.29
Interestingly, the chemotactic activity of soluble VCAM-1 is inhibited in the presence of anti-VCAM-1 and anti-VLA-4 [32], suggesting that VCAM-1 produced by RA-SFs contributes to the development of the synovial inflammation by attracting T cells to the joint.
Negative_regulation (inhibited) of VCAM-1 in joint associated with inflammation and rheumatoid arthritis
6) Confidence 0.09 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 0.97 Pain Relevance 0.14
An additional mechanism of its anti-inflammatory effect may be via suppression of adhesion molecules E-selectin, ICAM-1 and VCAM-1 (67).
Negative_regulation (suppression) of VCAM-1 associated with inflammation and adhesions
7) Confidence 0.06 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193557 Disease Relevance 1.11 Pain Relevance 0.42
These methods include nonspecific inhibition of pro-inflammatory mediators and adhesion molecules by nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, inhibition of cytokines and cytokine receptors, and inhibition of specific types of cell adhesion molecules, with inhibitors such as peptides and antibodies to beta2 integrins, and inhibitors of selectins, ICAMs, and vascular cell adhesion molecule-1 (VCAM-1).
Negative_regulation (inhibitors) of VCAM-1 associated with inflammatory mediators, inflammation, cinod, adhesions and cytokine
8) Confidence 0.05 Published 2001 Journal J. Vet. Intern. Med. Section Abstract Doc Link 11817056 Disease Relevance 0.84 Pain Relevance 0.40

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