INT99005

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.36
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2)
Anatomy Link Frequency
lung 2
hinge 1
lymphocyte 1
proximal 1
vesicle 1
Itgb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 96.08 Very High Very High Very High
antagonist 35 91.68 High High
cytokine 25 68.88 Quite High
Inflammation 54 44.48 Quite Low
antidepressant 30 38.00 Quite Low
fluoxetine 10 30.80 Quite Low
Serotonin 10 28.72 Quite Low
Kinase C 5 20.32 Low Low
sSRI 5 10.00 Low Low
chemokine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 225 99.80 Very High Very High Very High
Mycobacterial Infection 290 99.28 Very High Very High Very High
Cv General 3 Under Development 2 96.08 Very High Very High Very High
Vasculitis 1 94.28 High High
Myocardial Infarction 9 91.04 High High
Atherosclerosis 7 90.52 High High
Adhesions 29 90.16 High High
Targeted Disruption 30 76.08 Quite High
Necrosis 6 73.60 Quite High
Cancer 6 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, in this study, we reveal that the vesicle-absorption also involves intracellular signaling cascades initiated by TCR triggering and required for LFA-1 activation.
Positive_regulation (activation) of LFA-1 in vesicle
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.22 Pain Relevance 0
The pilot scale HTS validated the usefulness of our HTS platform in the systematic investigation of molecular mechanisms controlling TCR-mediated membrane-proximal signaling cascades leading to LFA-1 activation.
Positive_regulation (activation) of LFA-1 in proximal
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0.08
Expression of uPAR correlated with activation of beta(2)-integrins lymphocyte function-associated antigen 1 (LFA-1) and macrophage antigen 1 (Mac-1), measured by using monoclonal antibodies (mAbs) 24 and CBRM1/5.
Positive_regulation (activation) of lymphocyte function-associated antigen 1 in lymphocyte
3) Confidence 0.29 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.02 Pain Relevance 0.10
Here, strong binding may hinge crucially on prior TCR-dependent ‘inside-out’ signaling to activate LFA-1 function.
Positive_regulation (activate) of LFA-1 in hinge
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.07 Pain Relevance 0
In a high cholesterol/cholate model, a role of ICAM-1 and CD18 integrins was also shown, but this awaits confirmation in more physiologic models.
Positive_regulation (role) of CD18
5) Confidence 0.27 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.10 Pain Relevance 0.10
In view of the above results, we propose a mechanistic model that 2C T cell absorption of LdB7-1ICAM-1 pMV is preceded by the activation of LFA-1 (Figure 3).
Positive_regulation (activation) of LFA-1 in T cell
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
Prior to LFA-1 activation, the interaction of 2C TCRs with the cognate pMHCs may be too weak and transient to establish stable pMV absorption.
Positive_regulation (activation) of LFA-1
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
Accordingly, we found induction of transcripts encoding CD11a (ITGAL) and CD18 (ITGB2) on D21 in the M.tuberculosis infected lung (Table 5).
Positive_regulation (induction) of CD18 in lung associated with mycobacterial infection and infection
8) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.98 Pain Relevance 0
Accordingly, we found induction of transcripts encoding CD11a (ITGAL) and CD18 (ITGB2) on D21 in the M.tuberculosis infected lung (Table 5).
Positive_regulation (induction) of ITGB2 in lung associated with mycobacterial infection and infection
9) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.98 Pain Relevance 0

General Comments

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