INT9903

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.78
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYB5A) mitochondrion (CYB5A) small molecule metabolic process (CYB5A)
endoplasmic reticulum (CYB5A) enzyme binding (CYB5A) cytoplasm (CYB5A)
Anatomy Link Frequency
liver 5
Hep G2 1
CYB5A (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 1 97.40 Very High Very High Very High
lidocaine 5 96.06 Very High Very High Very High
Paracetamol 2 92.64 High High
Analgesic 1 10.00 Low Low
member 8 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 31 99.98 Very High Very High Very High
Hodgkin's Disease 77 99.52 Very High Very High Very High
Anaplastic Large Cell Lymphoma 19 98.88 Very High Very High Very High
Pox Virus Infection 1 90.04 High High
Avian Sarcoma 1 73.44 Quite High
Respiratory Syncytial Virus 1 71.84 Quite High
Diffuse Large B-cell Lymphoma 4 60.48 Quite High
Lymphatic System Cancer 25 50.00 Quite Low
Cancer 4 5.00 Very Low Very Low Very Low
B-cell Lymphoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of CYB5 Protein in HL Tissue Microarrays
Gene_expression (Expression) of CYB5 associated with hodgkin's disease
1) Confidence 0.37 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.25 Pain Relevance 0
P450 2E1 expressed in Hep G2 cells, a human cell line which contains both cytochrome b5 and NADPH:P450 oxidoreductase, was able to metabolize several known P450 2E1 substrates: N-nitrosodimethylamine (NDMA), N-nitrosomethylbenzylamine (NMBzA), p-nitrophenol, phenol, and acetaminophen.
Gene_expression (contains) of cytochrome b5 in Hep G2 associated with paracetamol
2) Confidence 0.32 Published 1992 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 1444447 Disease Relevance 0.09 Pain Relevance 0.09
This cell line expressed cytochrome b5 (58 +/- 12 pmol/mg microsomal protein vs 528 +/- 80 pmol/mg in microsomal human liver) and a high level of NADPH: cytochrome P450 reductase (140 +/- 20 nmol.min-1.mg microsomal protein-1 vs 68 +/- 48 nmol.min-1.mg-1 in microsomal human liver).
Gene_expression (expressed) of cytochrome b5 in liver
3) Confidence 0.18 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.15 Pain Relevance 0.05
The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes. 9-fold, 8-fold, and 30-fold rate increases were found respectively for nifedipine 1,4-oxidation, lidocaine N-deethylation and testosterone 6 beta-hydroxylation between P450 NF25-containing yeast microsomes from the basic strain and from the strain that both overexpresses yeast NADPH-P450 reductase and expresses human cytochrome b5.
Gene_expression (expresses) of cytochrome b5 in liver associated with sprains and strains and lidocaine
4) Confidence 0.15 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.27 Pain Relevance 0.10
Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.
Gene_expression (coexpressing) of cytochrome b5 in liver
5) Confidence 0.15 Published 1992 Journal Eur. J. Biochem. Section Title Doc Link 1628642 Disease Relevance 0.11 Pain Relevance 0.06
The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes. 9-fold, 8-fold, and 30-fold rate increases were found respectively for nifedipine 1,4-oxidation, lidocaine N-deethylation and testosterone 6 beta-hydroxylation between P450 NF25-containing yeast microsomes from the basic strain and from the strain that both overexpresses yeast NADPH-P450 reductase and expresses human cytochrome b5.
Gene_expression (express) of cytochrome b5 in liver associated with sprains and strains and lidocaine
6) Confidence 0.15 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.16 Pain Relevance 0.09
Even higher turnovers (15-fold, 20-fold and 50-fold rate increases) were obtained using P450 NF25-containing microsomes from the yeast just overexpressing yeast NADPH-P450 reductase in the presence of externally added, purified rabbit liver cytochrome b5.
Gene_expression (overexpressing) of cytochrome b5 in liver
7) Confidence 0.13 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.35 Pain Relevance 0.09
Indeed, addition of rabbit cytochrome b5 to microsomes from a strain expressing human cytochrome b5 did not further enhance the catalytic rates.
Gene_expression (expressing) of cytochrome b5 associated with sprains and strains
8) Confidence 0.12 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.40 Pain Relevance 0.07
INTERVENTIONS: The expression of microsomal cytochrome P450 (CYP) isoenzymes was examined after daily treatment of rats with intravenous zanamivir.
Gene_expression (expression) of microsomal cytochrome P450
9) Confidence 0.01 Published 1999 Journal Clin Pharmacokinet Section Body Doc Link 10429839 Disease Relevance 0 Pain Relevance 0

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