INT99039

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.96
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
brain 2
medial 1
nucleus 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 7 100.00 Very High Very High Very High
amygdala 3 100.00 Very High Very High Very High
Hippocampus 2 99.68 Very High Very High Very High
Morphine 9 99.04 Very High Very High Very High
Lasting pain 7 92.88 High High
Limbic system 4 88.80 High High
withdrawal 4 87.44 High High
Neuropathic pain 3 85.56 High High
Sciatic nerve 1 77.60 Quite High
dexamethasone 2 70.00 Quite High
Disease Link Frequency Relevance Heat
Injury 7 100.00 Very High Very High Very High
Nociception 2 95.36 Very High Very High Very High
Pain 7 92.88 High High
Stress 11 90.68 High High
Neuropathic Pain 3 85.56 High High
Traumatic Stress Disorders 1 67.72 Quite High
Anxiety Disorder 1 57.96 Quite High
Depression 1 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, glucocorticoid receptor mRNA expression in CCI rats was increased in the medial and central amygdala, unaffected in the paraventricular nucleus, and decreased in the hippocampus.
Neg (unaffected) Negative_regulation (decreased) of in nucleus Gene_expression (expression) of glucocorticoid receptor mRNA in medial associated with eae, hippocampus and amygdala
1) Confidence 0.37 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.71 Pain Relevance 1.33
Whole brain glucocorticoid receptor protein expression was reduced (approximately 70%) in morphine-treated rats 4-h after the final morphine injection and these levels recovered within 16-h.
Negative_regulation (reduced) of Gene_expression (expression) of glucocorticoid receptor protein in brain associated with morphine
2) Confidence 0.12 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679056 Disease Relevance 0.24 Pain Relevance 0.75

General Comments

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