INT9904

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2009
Negated 5
Speculated 1
Reported most in Abstract
Documents 64
Total Number 70
Disease Relevance 13.11
Pain Relevance 14.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2E1) oxidoreductase activity (CYP2E1) endoplasmic reticulum (CYP2E1)
enzyme binding (CYP2E1)
Anatomy Link Frequency
hepatocytes 4
liver 4
Hep G2 3
PC-12 2
epithelium 1
CYP2E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 139 99.72 Very High Very High Very High
Paracetamol 318 99.68 Very High Very High Very High
rapifen 7 97.82 Very High Very High Very High
Versed 2 93.20 High High
Dextromethorphan 2 92.28 High High
addiction 14 91.00 High High
Inflammation 289 81.48 Quite High
dexamethasone 1 78.96 Quite High
Chronic pancreatitis 5 77.60 Quite High
Analgesic 10 75.00 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 22 99.40 Very High Very High Very High
Apoptosis 353 99.36 Very High Very High Very High
Pox Virus Infection 6 98.60 Very High Very High Very High
Nasopharynx Cancer 103 98.48 Very High Very High Very High
Stress 651 98.04 Very High Very High Very High
Cancer 124 97.64 Very High Very High Very High
Toxicity 60 97.62 Very High Very High Very High
Infection 52 97.36 Very High Very High Very High
Fatty Liver 144 96.48 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 72 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand the basic effects and actions of CYP2E1, an approach has been established to utilize the cell lines that constitutively express human CYP2E1.
Gene_expression (express) of CYP2E1
1) Confidence 0.78 Published 2007 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 17567472 Disease Relevance 0.26 Pain Relevance 0.16
We investigated the effects of toluene exposure on expression of the CYP2E1 phenotype by measuring CYP2E1 mRNA induction in peripheral lymphocytes and CHZ metabolism in workers exposed to organic solvents and then determining whether these mRNA content and CHZ metabolic data were associated with genotype.
Gene_expression (expression) of CYP2E1 in lymphocytes
2) Confidence 0.78 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.12 Pain Relevance 0.03
Such induction could be a risk to the health of persons exposed to CYP2E1 protoxicant substrates; thus, CYP2E1 expression demands close monitoring in those individuals.


Gene_expression (expression) of CYP2E1
3) Confidence 0.78 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens.
Gene_expression (expression) of cytochrome P450 2E1
4) Confidence 0.78 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens.
Gene_expression (expression) of CYP2E1
5) Confidence 0.78 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Various factors, including exposure to certain xenobiotics, can induce CYP2E1 expression and thereby result in an increase in its metabolic activity.
Gene_expression (expression) of CYP2E1
6) Confidence 0.78 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
We examined biochemical parameters related to necrotic and apoptotic processes in acetaminophen-exposed PC12 cells is and in a PC12 cell line genetically engineered to express human CYP2E1.
Gene_expression (express) of CYP2E1 associated with paracetamol and apoptosis
7) Confidence 0.78 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9253715 Disease Relevance 0.10 Pain Relevance 0.42
Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1.
Gene_expression (transfected) of cytochrome P4502E1 associated with paracetamol
8) Confidence 0.78 Published 1997 Journal J. Mol. Med. Section Title Doc Link 9253715 Disease Relevance 0.08 Pain Relevance 0.44
This was more evident in CYP2E1-transfected cells.
Gene_expression (transfected) of CYP2E1
9) Confidence 0.78 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9253715 Disease Relevance 0.09 Pain Relevance 0.47
By transfection of an expression vector of human cytochrome P450 2E1 (CYP2E1) into a human hepatoma cell line (HLE), a new cell line (HLE/2E1) that stably expresses activity of CYP2E1 has been established.
Gene_expression (expresses) of CYP2E1 associated with hepatocellular cancer
10) Confidence 0.78 Published 2000 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 11212141 Disease Relevance 0.17 Pain Relevance 0.19
Apoptosis induced by APAP in HepG2 cells overexpressing CYP2E1 was caspase dependent and could be inhibited by the pan-caspase inhibitor Z-VAD-fmk.
Gene_expression (overexpressing) of CYP2E1 associated with paracetamol and apoptosis
11) Confidence 0.78 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.51 Pain Relevance 0.84
These results demonstrate that adenovirus-mediated overexpression of human CYP2E1 activates APAP to reactive metabolites which damage mitochondria, form protein adducts, and result in toxicity to HepG2 cells.
Gene_expression (overexpression) of CYP2E1 associated with toxicity and paracetamol
12) Confidence 0.78 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.46 Pain Relevance 0.85
To study the biochemical and toxicological properties of cytochrome P450 2E1 (CYP2E1), an adenovirus containing human CYP2E1 cDNA (Ad-CYP2E1) was constructed and was shown to successfully mediate the overexpression of CYP2E1 in HepG2 cells.
Gene_expression (overexpression) of CYP2E1
13) Confidence 0.78 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.36 Pain Relevance 0.53
Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity.
Gene_expression (overexpression) of CYP2E1 associated with paracetamol
14) Confidence 0.78 Published 2004 Journal Mol. Cell. Biochem. Section Title Doc Link 15532721 Disease Relevance 0.37 Pain Relevance 0.67
Construction of recombinant cell lines expressing CYP2E1 provides a useful tool for studying the catalytic properties of this enzyme and the consequent cytotoxic effects of substrates metabolized by this enzyme.
Gene_expression (expressing) of CYP2E1
15) Confidence 0.77 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.11 Pain Relevance 0.09
Although the level of the enzyme activities was about a tenth of that measured in human liver microsomes, CYP2E1 expressed in DB-7 cells has catalytic competence similar to human liver CYP2E1.
Gene_expression (expressed) of CYP2E1 in liver
16) Confidence 0.77 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.13 Pain Relevance 0.09
Clones were selected for resistance to the neomycin analog, G418, and then screened for expression of the CYP2E1 isozyme by testing for 6-hydroxylation of chlorzoxazone, a specific substrate for CYP2E1.
Gene_expression (expression) of CYP2E1
17) Confidence 0.77 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.19 Pain Relevance 0.04
Expression of CYP2E1 was confirmed in one clone, DB-7, by Western blot analysis and by measurement of monooxygenase activities which were not detectable in PC-12 cells.
Gene_expression (Expression) of CYP2E1 in PC-12
18) Confidence 0.77 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.18 Pain Relevance 0.04
The stable expression of the human cytochrome CYP2E1 (P450 alcohol) was performed in the mammalian cell line PC-12.
Gene_expression (expression) of CYP2E1 in PC-12 associated with alcohol
19) Confidence 0.77 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.13 Pain Relevance 0.05
High-level expression of human and rat cytochrome P450 2E1 (CYP2E1) was achieved using a baculovirus expression system.
Gene_expression (expression) of CYP2E1
20) Confidence 0.77 Published 1996 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 8914842 Disease Relevance 0 Pain Relevance 0

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