INT99049

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.68
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Hcn1)
Anatomy Link Frequency
neurons 2
ovary 1
Hcn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 44 100.00 Very High Very High Very High
hCN2 27 100.00 Very High Very High Very High
Inflammation 7 98.56 Very High Very High Very High
Serotonin 1 97.76 Very High Very High Very High
Action potential 2 97.28 Very High Very High Very High
Opioid 1 95.76 Very High Very High Very High
Glutamate 1 95.44 Very High Very High Very High
opioid receptor 3 95.28 Very High Very High Very High
nMDA receptor 1 94.16 High High
agonist 2 93.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 98.56 Very High Very High Very High
Ganglion Cysts 4 75.00 Quite High
Nociception 3 75.00 Quite High
Pain 1 62.44 Quite High
Nervous System Injury 1 61.92 Quite High
Lifespan 1 36.96 Quite Low
Aging 22 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aim of this study was to test the hypothesis that levels of hyperpolarization activated cyclic nucleotide gated channels 1 to 4 (HCN1-4) are linked to the reproductive age of the ovary.


Positive_regulation (activated) of HCN1 in ovary associated with hcn1
1) Confidence 0.43 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.15
In addition, the number of retrogradely labeled neurons from the dura expressing HCN1 and HCN2 was significantly increased to 247% (HCN1) and 171% (HCN2), three days after inflammation.
Positive_regulation (increased) of HCN1 in neurons associated with inflammation, hcn1 and hcn2
2) Confidence 0.40 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.60 Pain Relevance 1.32
Both receptors enhanced HCN2, but not HCN1 currents.
Neg (not) Positive_regulation (enhanced) of HCN1 associated with hcn1 and hcn2
3) Confidence 0.28 Published 2001 Journal Pflugers Arch. Section Abstract Doc Link 11680627 Disease Relevance 0 Pain Relevance 0.58
Increasing network activity with high extracellular K+ caused a similar reduction of cellular excitability and an increase in h-channel HCN1 protein.
Positive_regulation (increase) of HCN1 protein associated with hcn1
4) Confidence 0.24 Published 2005 Journal Nat. Neurosci. Section Abstract Doc Link 16234810 Disease Relevance 0 Pain Relevance 0.41
Hyperpolarization-activated cyclic nucleotide-gated cation channel proteins (HCN1-4), which are potentially able to modulate membrane excitability, are abundantly expressed by neurons in spinal dorsal root ganglia (DRG).
Positive_regulation (Hyperpolarization-activated) of HCN1-4 in neurons associated with hcn1
5) Confidence 0.19 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15016091 Disease Relevance 0.07 Pain Relevance 0.28

General Comments

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