INT9905

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 2.49
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DECR1) small molecule metabolic process (DECR1) nucleolus (DECR1)
nucleus (DECR1) cytoplasm (DECR1)
Anatomy Link Frequency
liver 2
dental pulp 2
RBC 1
endothelial cells 1
vasculature 1
DECR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 7 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
methadone 2 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
cINOD 12 98.74 Very High Very High Very High
alcohol 1 97.40 Very High Very High Very High
Inflammatory response 2 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 9 98.44 Very High Very High Very High
Stress 17 97.40 Very High Very High Very High
Neurodegenerative Disease 2 96.64 Very High Very High Very High
INFLAMMATION 8 96.04 Very High Very High Very High
Pox Virus Infection 1 90.04 High High
Anaemia 1 89.92 High High
Pain 1 86.60 High High
Pulpitis 4 85.76 High High
Avian Sarcoma 1 82.48 Quite High
Increased Venous Pressure Under Development 8 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to examine the expression of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity in human dental pulps and determine whether there are changes of the activity in chronically inflamed pulp tissue.
Spec (examine) Gene_expression (expression) of NADPH in dental pulps
1) Confidence 0.75 Published 2002 Journal Coll Antropol Section Abstract Doc Link 12528299 Disease Relevance 0.09 Pain Relevance 0.09
Cytochromes P-450 and b5, NADPH and NADH cytochrome c reductase, methadone and meperidine N-demethylase and morphine glucuronyltransferase activities were detected in microsomes from both maternal and fetal livers.
Gene_expression (detected) of NADPH in livers associated with methadone and morphine
2) Confidence 0.75 Published 1986 Journal Dev Pharmacol Ther Section Abstract Doc Link 3757733 Disease Relevance 0 Pain Relevance 0.40
This cell line expressed cytochrome b5 (58 +/- 12 pmol/mg microsomal protein vs 528 +/- 80 pmol/mg in microsomal human liver) and a high level of NADPH: cytochrome P450 reductase (140 +/- 20 nmol.min-1.mg microsomal protein-1 vs 68 +/- 48 nmol.min-1.mg-1 in microsomal human liver).
Gene_expression (expressed) of NADPH in liver
3) Confidence 0.75 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.16 Pain Relevance 0.05
The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.
Gene_expression (expression) of NADPH in endothelial cells associated with hypertension and cinod
4) Confidence 0.65 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.70
The purpose of this study was to analyze normal and inflamed human dental pulp for the presence of NADPH-diaphorase (NADPH-d), as an index of NO system activity.
Spec (analyze) Gene_expression (presence) of NADPH in dental pulp
5) Confidence 0.65 Published 2008 Journal Micron Section Abstract Doc Link 18337111 Disease Relevance 0.43 Pain Relevance 0.34
Using indirect immunohistochemistry, we analyzed the distribution of calretinin (CR), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA), vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS), tyrosine hydroxylase (TH), histamine, serotonin, enkephalin, and, enzyme histochemically, NADPH-diaphorase (NADPH-d).
Spec (analyzed) Gene_expression (distribution) of NADPH associated with neuropeptide, enkephalin, serotonin, substance p and calcitonin gene-related peptide
6) Confidence 0.65 Published 1997 Journal Acta Histochem. Section Abstract Doc Link 9381913 Disease Relevance 0 Pain Relevance 0.68
In the presence of the cytochrome P-450 co-factor, NADPH, the main metabolites recovered were delta 3-VPA, delta 2,4-VPA and VPA.
Gene_expression (presence) of NADPH
7) Confidence 0.65 Published 1992 Journal Pharm Weekbl Sci Section Abstract Doc Link 1502016 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: NADH/NADPH oxidase is an important source of reactive oxygen species (ROS) in the vasculature.
Gene_expression (source) of NADPH in vasculature
8) Confidence 0.58 Published 2002 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 12426213 Disease Relevance 0.23 Pain Relevance 0.07
In the present study, we have identified a novel mechanism involved in microglial NADPH oxidase-mediated ROS production.
Gene_expression (production) of NADPH
9) Confidence 0.58 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19683814 Disease Relevance 0.10 Pain Relevance 0
Together, our data suggest that TRPV1 channels are involved in regulating NADPH oxidase-mediated ROS generation in microglia.
Gene_expression (generation) of NADPH in microglia
10) Confidence 0.58 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19683814 Disease Relevance 0.08 Pain Relevance 0
It is synthesized in endothelial and other cell types from L-arginine by a calcium-calmodulin and NADPH-dependent enzyme.
Gene_expression (synthesized) of NADPH
11) Confidence 0.29 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1868189 Disease Relevance 0.37 Pain Relevance 0
P450 2E1 expressed in Hep G2 cells, a human cell line which contains both cytochrome b5 and NADPH:P450 oxidoreductase, was able to metabolize several known P450 2E1 substrates: N-nitrosodimethylamine (NDMA), N-nitrosomethylbenzylamine (NMBzA), p-nitrophenol, phenol, and acetaminophen.
Gene_expression (contains) of NADPH in Hep G2 associated with paracetamol
12) Confidence 0.26 Published 1992 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 1444447 Disease Relevance 0.09 Pain Relevance 0.09
HPN, NDN, ATR, ABL2, DHRS2), development and cellular differentiation (CLEC3B, KCNJ8, ADAM29, DNMT3A), fatty acid and steroid metabolism (LPIN1, DECR1, ACSL3) and intracellular signaling transduction (PPAP2C, PPP3CA, PRSS23, GRB10, SIPA1L2).
Gene_expression (transduction) of DECR1
13) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.13 Pain Relevance 0
In cells exposed to high levels of oxidative stress, like red blood cells (RBC), up to 10% of the glucose consumption may be directed to the pentose phosphate pathway (PPP) for the production of the NADPH needed for this reaction.
Gene_expression (production) of NADPH in RBC associated with stress
14) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2657797 Disease Relevance 0.48 Pain Relevance 0

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