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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.66
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Hcn1)
Anatomy Link Frequency
neurons 1
brain 1
oocytes 1
Hcn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 42 100.00 Very High Very High Very High
hCN2 17 100.00 Very High Very High Very High
Inflammation 7 99.44 Very High Very High Very High
Trigeminal ganglion neurons 2 97.72 Very High Very High Very High
Opioid 1 96.92 Very High Very High Very High
Neurotransmitter 1 96.36 Very High Very High Very High
Serotonin 1 95.04 Very High Very High Very High
Pain 1 93.56 High High
Neuronal excitability 1 89.72 High High
Buprenorphine 2 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.44 Very High Very High Very High
Ganglion Cysts 4 97.28 Very High Very High Very High
Pain 1 93.56 High High
Nervous System Injury 1 93.04 High High
Overdose 1 69.88 Quite High
Aging 22 57.20 Quite High
Lifespan 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Positive control for HCN1-4 was brain RNA and the negative control was running the PCR reaction without the cDNA template.
Regulation (control) of HCN1 in brain associated with hcn1
1) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.13 Pain Relevance 0.10
HCN1 and HCN2 channel immunoreactivity was observed on the membranes of medium- to large-sized trigeminal ganglion neurons with 76% and 85% of HCN1 and HCN2 expressing neurons also containing the 200 kDa neurofilament protein (associated with myelinated fibers).
Regulation (immunoreactivity) of HCN1 in neurons associated with ganglion cysts, hcn1, trigeminal ganglion neurons and hcn2
2) Confidence 0.26 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.53 Pain Relevance 0.71
In this study, we investigated the modulation of two cloned pacemaker channels, HCN1 and HCN2, by activation of coexpressed inhibitory G protein (Gi)-coupled (p-opioid) or stimulatory G protein (Gs)-coupled [serotonin 5-HT4(a)] receptors in Xenopus oocytes.
Spec (investigated) Regulation (modulation) of HCN1 in oocytes associated with hcn1, serotonin, opioid and hcn2
3) Confidence 0.15 Published 2001 Journal Pflugers Arch. Section Abstract Doc Link 11680627 Disease Relevance 0 Pain Relevance 0.52

General Comments

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