INT99058

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 21.62
Pain Relevance 18.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
neurons 2
spinal 1
PAG 1
medial 1
thalamus 1
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 545 100.00 Very High Very High Very High
Periaqueductal grey 231 100.00 Very High Very High Very High
Rostral ventromedial medulla 153 100.00 Very High Very High Very High
Chronic low back pain 67 100.00 Very High Very High Very High
lidocaine 29 100.00 Very High Very High Very High
amygdala 198 99.98 Very High Very High Very High
GABAergic 65 99.96 Very High Very High Very High
Pain 526 99.84 Very High Very High Very High
Morphine 237 99.80 Very High Very High Very High
Osteoarthritis 77 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 907 100.00 Very High Very High Very High
Low Back Pain 74 100.00 Very High Very High Very High
Nociception 92 99.98 Very High Very High Very High
Pain 637 99.84 Very High Very High Very High
Knee Osteoarthritis 76 99.80 Very High Very High Very High
Panic Disorder 66 98.92 Very High Very High Very High
Migraine Disorders 102 97.76 Very High Very High Very High
Stress 340 96.76 Very High Very High Very High
Pruritus 13 95.00 High High
Anxiety Disorder 249 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The available data and the limited number of studies in the topic, therefore, underscore the need for larger, placebo controlled fMRI trials for efficacy of lidocaine patch therapy in both CBP and OA patients.


Regulation (need) of CBP associated with chronic low back pain, osteoarthritis and lidocaine
1) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584040 Disease Relevance 1.03 Pain Relevance 1.27
PAG is well known to be a modulating noxious stimulus.
Regulation (modulating) of PAG in PAG associated with urological neuroanatomy
2) Confidence 0.35 Published 2003 Journal Pain Section Abstract Doc Link 14499452 Disease Relevance 1.52 Pain Relevance 0.61
continuous administration of morphine into the ventrolateral PAG of male rats
Regulation (ventrolateral) of PAG associated with central grey and morphine
3) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.05 Pain Relevance 2.19
binding sites in the ventrolateral PAG attenuates the development of tolerance
Regulation (ventrolateral) of PAG associated with tolerance and central grey
4) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.99 Pain Relevance 2.16
measure the activity of populations of PAG-RVM neurons in the PAG of males and females.
Regulation (populations) of PAG in neurons associated with central grey and rostral ventromedial medulla
5) Confidence 0.35 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.28 Pain Relevance 1.65
To investigate the influence of the PAG on pain transmission from intracranial structures, we examined spinal trigeminal neuronal activity in response to PAG stimulation in a model of trigeminovascular nociception in the cat.
Spec (investigate) Regulation (influence) of PAG in spinal associated with nociception, pain and periaqueductal grey
6) Confidence 0.24 Published 2001 Journal Neuroscience Section Abstract Doc Link 11682164 Disease Relevance 1.31 Pain Relevance 0.90
PAG is normally regulated by tonic activity of GABAergic neurones.
Regulation (regulated) of PAG associated with gabaergic and periaqueductal grey
7) Confidence 0.23 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 0.80 Pain Relevance 0.79
provide evidence for a participation of the PAG in the pathophysiology of PD.

2.

Regulation (participation) of PAG associated with panic disorder and urological neuroanatomy
8) Confidence 0.23 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.69 Pain Relevance 0.24
Therefore, in this new analysis of previously unpublished data collected in a randomized placebo-controlled study [29,30], we investigated the functional connectivity of PAG changes during EA stimulation and sham EA stimulation at acupoints Large Intestine 3 and 4 (LI3 and LI4) on the right hand.
Spec (investigated) Regulation (changes) of PAG in Intestine associated with urological neuroanatomy and electroacupuncture
9) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2993660 Disease Relevance 0.72 Pain Relevance 0.79
The PAG is also involved in
Regulation (involved) of PAG associated with periaqueductal grey
10) Confidence 0.20 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 0.54 Pain Relevance 0.22
regime elicits differential expression of the immediate early gene c-fos in the ventrolateral PAG in rats in
Regulation (ventrolateral) of PAG associated with periaqueductal grey
11) Confidence 0.20 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 1.62 Pain Relevance 0.95
The ventrolateral PAG contains neurons that are a source of descending facilitation of
Regulation (ventrolateral) of PAG in neurons associated with periaqueductal grey and ascending facilitation
12) Confidence 0.20 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 1.69 Pain Relevance 1.02
control system in the PAG in females, changes in the functional excitability of
Regulation (control) of PAG associated with periaqueductal grey
13) Confidence 0.20 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 0.72 Pain Relevance 0.70
The anterior cingulate and frontal cortices are part of a descending pain modulatory system that exerts top-down influences on the periaqueductal grey (PAG) and posterior thalamus to gate pain modulation [14].
Regulation (influences) of PAG in thalamus associated with pain, periaqueductal grey, urological neuroanatomy, thalamus and anterior cingulate
14) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.39 Pain Relevance 1.46
that long lasting right CeA-PAG pathway potentiation is dependent on pCREB expression [7, 40].
Regulation (dependent) of PAG associated with central grey and amygdala
15) Confidence 0.06 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.42 Pain Relevance 0.85
Brainstem centers such as the PAG normally receive and modulate sensory neuronal input.
Regulation (modulate) of PAG associated with medulla and urological neuroanatomy
16) Confidence 0.05 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386351 Disease Relevance 1.21 Pain Relevance 1.32
pCREB expression between predator stressed and handled controls in ventral PAG of both hemispheres, with right hemisphere
Regulation (controls) of PAG in ventral associated with central grey
17) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.53 Pain Relevance 0.19
OD values in particular PAG areas
Regulation (values) of PAG associated with central grey
18) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.99 Pain Relevance 0.31
Although little available evidence supports direct linkage between the medial and the lateral pain systems [34], our prior and current results both suggest the medial system may modulate lateral system during nociceptive processing, Based on the fact that the medial system is composed of the medial and intralaminar thalamic nuclei and limbic cortical areas which have descending projections to nociception regulating centres such as PAG, it is possible that the medial system modulates somatosensory nociceptive transmission through the brainstem structures that control both spinal and trigeminal dorsal horn pain transmission neurons.
Regulation (regulating) of PAG in medial associated with nociception, medulla, pain, periaqueductal grey and dorsal horn
19) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2531182 Disease Relevance 1.12 Pain Relevance 0.89

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