INT99059

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 3.12
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb1) extracellular region (Cpb1) cellular_component (Cpb1)
biological_process (Cpb1)
Anatomy Link Frequency
neutrophils 3
blood 2
upper 1
stems 1
heart 1
Cpb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 27 100.00 Very High Very High Very High
metalloproteinase 48 99.76 Very High Very High Very High
Dopamine 12 97.84 Very High Very High Very High
Inflammatory response 8 93.76 High High
Ultiva 12 91.96 High High
Hippocampus 6 89.12 High High
Opioid 3 73.56 Quite High
Inflammatory mediators 2 68.32 Quite High
isoflurane 1 61.96 Quite High
Inflammation 4 59.76 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 8 100.00 Very High Very High Very High
Hyperglycemia 36 99.50 Very High Very High Very High
Cognitive Disorder 5 94.00 High High
INFLAMMATION 12 93.40 High High
Neurodegenerative Disease 4 93.08 High High
Increased Venous Pressure Under Development 6 90.68 High High
Hypothermia 5 88.56 High High
Pressure And Volume Under Development 2 81.92 Quite High
Arrhythmias 2 Under Development 4 76.64 Quite High
Coronary Heart Disease 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Group 1 had increased ratios of bcl-2/beta-actin, bax/beta-actin, and bax/bcl-2 mRNA at 1 h after CPB (bcl-2/beta-actin, 0.82 +/- 0.14 versus 0.63 +/- 0.07; P = 0.03; bax/beta-actin, 1.04 +/- 0.14 versus 0.56 +/- 0.03; P = 0.00; bax/bcl-2, 1.31 +/- 0.12 versus 0.84 +/- 0.09; P = 0.02; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of CPB
1) Confidence 0.45 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.36 Pain Relevance 0.24
The volume of distribution increased by 86% with institution of CPB and remained increased after CPB.
Positive_regulation (increased) of CPB
2) Confidence 0.40 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11682375 Disease Relevance 0.17 Pain Relevance 0.83
In the cases of open-heart surgery with CPB, PSLCO2 increased from 35.0 +/- 5.6 mmHg at the induction of anesthesia to the maximum value of 55.7 +/- 6.0 mmHg during CPB.
Positive_regulation (induction) of CPB in heart associated with anesthesia
3) Confidence 0.40 Published 2002 Journal Masui Section Abstract Doc Link 12428329 Disease Relevance 0 Pain Relevance 0.10
The value of arterial lactate as another index of peripheral blood perfusion also increased gradually after the start of CPB, reaching to the maximum value of 8.8 +/- 1.1 mmol.l-1 just after being admitted into ICU.
Positive_regulation (increased) of CPB in blood
4) Confidence 0.40 Published 2002 Journal Masui Section Abstract Doc Link 12428329 Disease Relevance 0 Pain Relevance 0.09
However, neurological complications can result after both CPB and DHCA.
Positive_regulation (result) of CPB
5) Confidence 0.40 Published 2007 Journal Life Sci. Section Abstract Doc Link 17658556 Disease Relevance 0.28 Pain Relevance 0.07
Compared with the non-CPB controls, the CPB group had significantly increased levels of apoptotic/GAPDH mRNA ratios (bcl-x, 0.414 +/- 0.152 CPB versus 0.251 +/- 0.051 non-CPB, P = 0.048; caspase 2, 0.030 +/- 0.014 CPB versus 0.018 +/- 0.005 non-CPB, P = 0.048; bax, 0.106 +/- 0.035 CPB versus 0.066 +/- 0.009 non-CPB, P = 0.009; bcl-2, 0.011 +/- 0.006 CPB versus 0.006 +/- 0.002 non-CPB, P = 0.035).
Positive_regulation (increased) of CPB associated with apoptosis
6) Confidence 0.31 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12031994 Disease Relevance 0.54 Pain Relevance 0
Serum concentrations of MMPs and their inhibitors, CD11b and CD66b expression on neutrophils were sequentially measured before induction of anesthesia, at the initiation of CPB, after 30 minutes of CPB, at the end of CPB, 4 and 48 hours after CPB.
Positive_regulation (end) of CPB in neutrophils associated with anesthesia
7) Confidence 0.15 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.32 Pain Relevance 0.40
Serum concentrations of MMPs and their inhibitors, CD11b and CD66b expression on neutrophils were sequentially measured before induction of anesthesia, at the initiation of CPB, after 30 minutes of CPB, at the end of CPB, 4 and 48 hours after CPB.
Positive_regulation (end) of CPB in neutrophils associated with anesthesia
8) Confidence 0.15 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.32 Pain Relevance 0.40
Tissue damping increased in the CPB and OPCAB groups, whereas it remained constant in the CPB-DA patients.
Positive_regulation (increased) of CPB associated with dopamine
9) Confidence 0.12 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12707120 Disease Relevance 0.08 Pain Relevance 0.31
Airway resistance increased in the CPB group (74.9% +/- 20.8%; P < 0.05), whereas it did not change in the OPCAB group (11.8% +/- 7.9%; not significant) and even decreased in the CPB-DA patients (-40.6% +/- 9.2%; P < 0.05).
Positive_regulation (increased) of CPB associated with dopamine
10) Confidence 0.12 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12707120 Disease Relevance 0.06 Pain Relevance 0.25
Only the patients with associated HL and hyperglycemia had significantly lower values of Do2 on CPB.
Positive_regulation (values) of CPB associated with hyperglycemia
11) Confidence 0.06 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.74 Pain Relevance 0
This management strategy stems from our early observation that patients who underwent a hybrid procedure had diminished cardiac output, high systemic vascular resistance, and a high pulmonary-to-systemic flow ratio (Qp/Qs) despite avoiding CPB/DHCA (see Early post-operative physiology)22)
Positive_regulation (avoiding) of CPB in stems
12) Confidence 0.04 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844974 Disease Relevance 0.09 Pain Relevance 0.05
In our series of 256 pediatric patients, this pattern was confirmed for ScVO2 values below 68%, with a significant increase of peak lactate during CPB, and may be interpreted as a condition of increased oxygen-extraction rate, insufficient to cover the VO2, with activation of anaerobic energy production (upper left quadrant of Figure 5).
Positive_regulation (increase) of CPB in upper
13) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
The neutrophil content of MMP-9 and mRNA increased significantly 2 h after beginning CPB.
Positive_regulation (increased) of CPB in neutrophil associated with metalloproteinase
14) Confidence 0.03 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920174 Disease Relevance 0.07 Pain Relevance 0.83
Increased levels of MMP-9 have been observed in patients undergoing CPB.
Positive_regulation (undergoing) of CPB associated with metalloproteinase
15) Confidence 0.03 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920174 Disease Relevance 0.09 Pain Relevance 0.52
The patient population was arranged in order of increasing peak blood glucose levels, lowest Do2, and CPB duration, and a total of 37 subgroups (75% overlapping ranges) were analyzed with respect to the HL incidence.
Positive_regulation (increasing) of CPB in blood
16) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0 Pain Relevance 0

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