INT99068

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 2
Speculated 4
Reported most in Body
Documents 62
Total Number 66
Disease Relevance 33.57
Pain Relevance 21.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
retinas 4
spinal cord 4
neurons 3
hepatocytes 2
liver 1
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 228 100.00 Very High Very High Very High
Paracetamol 31 99.98 Very High Very High Very High
intrathecal 4 99.98 Very High Very High Very High
ischemia 577 99.84 Very High Very High Very High
Spinal cord 51 99.82 Very High Very High Very High
Spinal nerve ligature 7 99.82 Very High Very High Very High
qutenza 8 99.78 Very High Very High Very High
Kinase C 96 99.76 Very High Very High Very High
dorsal root ganglion 20 99.20 Very High Very High Very High
Dorsal horn 7 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 10 100.00 Very High Very High Very High
Cv Unclassified Under Development 448 99.84 Very High Very High Very High
Stress 510 99.58 Very High Very High Very High
Injury 292 99.44 Very High Very High Very High
Death 410 99.20 Very High Very High Very High
Retina Disease 125 99.20 Very High Very High Very High
Ganglion Cysts 107 99.20 Very High Very High Very High
INFLAMMATION 182 99.12 Very High Very High Very High
Sepsis 85 98.46 Very High Very High Very High
Fibrosis 11 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, phosphorylated JNK 46 kDa was normally expressed in the S1 area, but not in the spinal cord, while neither of the two structures contained phosphorylated JNK 54 kDa.
Neg (not) Gene_expression (pressed i) of JNK in spinal cord associated with spinal cord
1) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17923323 Disease Relevance 0.23 Pain Relevance 0.52
Daily intrathecal administration of quercetin (inhibitor of JNK pathway) 100 microg/rat, or 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide (PTIO; NO scavenger) 30 mug/rat before injection of 5% formalin led to a reliable reduction in the number of dark neurons.
Gene_expression (administration) of JNK in neurons associated with intrathecal
2) Confidence 0.68 Published 2006 Journal Synapse Section Abstract Doc Link 16284960 Disease Relevance 0.42 Pain Relevance 0.62
In naïve rats, no significant difference was observed in total expression level of the two JNK isoforms between spinal cord and primary somatosensory cortex (S1 area).
Gene_expression (expression) of JNK in primary somatosensory cortex associated with primary somatosensory cortex and spinal cord
3) Confidence 0.67 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17923323 Disease Relevance 0.17 Pain Relevance 0.46
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Gene_expression (levels) of JNK in spinal cord associated with spinal cord
4) Confidence 0.65 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.59 Pain Relevance 0.70
Furthermore, we found that preemptive edaravone treatment can reduce the SNL-induced pJNK expression in the ipsilateral DRG.
Gene_expression (expression) of pJNK in DRG associated with dorsal root ganglion and spinal nerve ligature
5) Confidence 0.62 Published 2009 Journal Brain Res. Section Abstract Doc Link 19028459 Disease Relevance 1.43 Pain Relevance 1.84
Moreover, the increased NR2B-immunoreactivity (IR) and phosphorylated JNK-IR were observed mainly at the superficial dorsal horn laminae of the spinal cord; the spinal p-JNK was mainly expressed in astrocytes and NR2B in neurons.
Gene_expression (expressed) of JNK in astrocytes associated with dorsal horn and spinal cord
6) Confidence 0.59 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.58
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
Gene_expression (expressions) of JNK
7) Confidence 0.51 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
In addition, the numbers of ASK1-, p-SEK1/MEK4-, and p-JNK-positive cells that were double stained with Fluoro-Jade B were counted in the GCL.
Gene_expression (counted) of JNK
8) Confidence 0.47 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.13 Pain Relevance 0
Sepsis induced an increase in the expression/activation of TLR4 and its downstream signaling JNK and IKK/NF-?
Gene_expression (signaling) of JNK associated with sepsis
9) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2997789 Disease Relevance 0.71 Pain Relevance 0.20
There are three subfamilies of MAPKs: extracellular signal-regulated kinases (ERK), NH2-terminal kinases (JNK), and P38 kinase.
Gene_expression (kinases) of NH2-terminal
10) Confidence 0.45 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.20 Pain Relevance 0
There are three subfamilies of MAPKs: extracellular signal-regulated kinases (ERK), NH2-terminal kinases (JNK), and P38 kinase.
Gene_expression (kinases) of JNK
11) Confidence 0.45 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.20 Pain Relevance 0
The membranes were then incubated with an anti-rabbit phospho-JNK/JNK antibody, anti-rabbit phospho-ERK/ERK, anti-rabbit phospho-p38 MAP kinase/p38 MAP kinase, antiserum against rat CINC, anti-human MMP-9 monoclonal antibody or anti-rabbit phospho-I?
Gene_expression (antibody) of JNK associated with metalloproteinase
12) Confidence 0.44 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0 Pain Relevance 0.13
The membranes were then incubated with an anti-rabbit phospho-JNK/JNK antibody, anti-rabbit phospho-ERK/ERK, anti-rabbit phospho-p38 MAP kinase/p38 MAP kinase, antiserum against rat CINC, anti-human MMP-9 monoclonal antibody or anti-rabbit phospho-I?
Gene_expression (antibody) of JNK associated with metalloproteinase
13) Confidence 0.44 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0 Pain Relevance 0.13
Similar to a past report (Roth et al 2003), our data showed that JNK expression was detected in many types of cells that were not Fluoro-Jade B positive in ischemic retinas.
Gene_expression (expression) of JNK in retinas
14) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.63 Pain Relevance 0.05
Our data on JNK expression at the initial phase after reperfusion is consistent with their report.
Gene_expression (expression) of JNK
15) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.63 Pain Relevance 0.05
Semi-quantitative analysis of expression of ASK1, p-SEK1/MEK4, and p-JNK in the GCL
Gene_expression (expression) of JNK
16) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.15 Pain Relevance 0
JNK expression as well as ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Gene_expression (expression) of JNK
17) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.61 Pain Relevance 0.04
Roth and colleagues (2003) reported that JNK expression was significantly increased within 6 hours after ischemia-reperfusion.
Gene_expression (expression) of JNK associated with ischemia
18) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.59 Pain Relevance 0.05
, ASK1, SEK1/MEK4, and JNK expression with neuronal cell death of ischemic retinas.
Gene_expression (expression) of JNK in retinas associated with death
19) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.48 Pain Relevance 0.03
Very few cells that expressed p-JNK in the INL of ischemic retinas were co-stained with Fluoro-Jade B (Figure 7C and D).
Gene_expression (expressed) of JNK in retinas
20) Confidence 0.42 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox