INT99069

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 42
Total Number 49
Disease Relevance 29.84
Pain Relevance 23.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
neurons 17
spinal cord 14
heart 8
spinal 6
microglia 5
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 450 100.00 Very High Very High Very High
Spinal cord 266 100.00 Very High Very High Very High
Dopamine 226 100.00 Very High Very High Very High
cytokine 153 100.00 Very High Very High Very High
fibrosis 73 100.00 Very High Very High Very High
Hyperalgesia 39 100.00 Very High Very High Very High
gABA 27 100.00 Very High Very High Very High
metalloproteinase 13 100.00 Very High Very High Very High
antagonist 120 99.84 Very High Very High Very High
spinal dorsal horn 53 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 513 100.00 Very High Very High Very High
Apoptosis 237 100.00 Very High Very High Very High
Hyperalgesia 104 100.00 Very High Very High Very High
Fibrosis 62 100.00 Very High Very High Very High
Coronary Heart Disease 50 100.00 Very High Very High Very High
Hypersensitivity 126 99.90 Very High Very High Very High
Cancer 29 99.84 Very High Very High Very High
Myocardial Infarction 390 99.72 Very High Very High Very High
Cardiovascular Disorder Under Development 10 99.68 Very High Very High Very High
Necrosis 22 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-IL-10 antibody and SB203580 significantly inhibited the amitriptyline-induced p38 mitogen-activated protein kinase and heme oxygenase-1 expression and the associated antiinflammatory effect of amitriptyline.
Positive_regulation (induced) of Gene_expression (expression) of p38
1) Confidence 0.53 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Positive_regulation (activated) of Spec (investigate) Gene_expression (expression) of p38 in spinal
2) Confidence 0.50 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Positive_regulation (activated) of Spec (investigate) Gene_expression (expression) of p38 in spinal
3) Confidence 0.50 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Positive_regulation (activated) of Spec (investigate) Gene_expression (expression) of p38 in spinal
4) Confidence 0.50 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
Protein expression of myocardial p38 was increased after MI in Wistar rats (Figure 7A).
Positive_regulation (increased) of Gene_expression (expression) of p38 associated with myocardial infarction
5) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.35 Pain Relevance 0
Long-term p38 MAPK activation has been shown to increase cardiac hypertrophy, fibrosis and apoptosis suggestive of a deleterious effect on the heart [24-26] and p38 MAPK overexpression has been shown to induce proinflammatory and profibrotic genes [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p38 in heart associated with fibrosis, apoptosis and coronary heart disease
6) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.33 Pain Relevance 0.09
Proinflammatory cytokine production via p38 MAPK appears to be dependent on tumor necrosis factor-alpha (TNF-?)
Positive_regulation (dependent) of Gene_expression (production) of p38 associated with necrosis, cancer and cytokine
7) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.48 Pain Relevance 1.10
As shown in Figure 1A, P-p38 levels increased in individual rats between days 8 and 17 after immunization.
Positive_regulation (increased) of Gene_expression (levels) of p38 associated with immunization
8) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.28 Pain Relevance 0.16
The change in gap junction activity was accompanied by increased expression of connexin 26 and active p38 levels in both neurons and satellite glia in V1 and V2 regions.
Positive_regulation (increased) of Gene_expression (expression) of p38 in neurons
9) Confidence 0.46 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
Pretreatment with tonabersat inhibited gap junction communication between neurons and satellite glia and blocked the increase in connexin 26 and active p38 levels in response to injection of both tumor necrosis factor-alpha (V2) and capsaicin (V1).
Positive_regulation (increase) of Gene_expression (levels) of p38 in neurons
10) Confidence 0.46 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
The change in gap junction activity was accompanied by increased expression of connexin 26 and active p38 levels in both neurons and satellite glia in V1 and V2 regions.
Positive_regulation (increased) of Gene_expression (levels) of p38 in neurons
11) Confidence 0.46 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
Intrathecal IL-1beta leads to a time-dependent up-regulation of phosphorylated p38 (p-p38) MAPK protein expression in the spinal cord 30-240 min following IL-1beta injection (i.t.).
Positive_regulation (regulation) of Gene_expression (expression) of p38 in spinal cord associated with spinal cord and intrathecal
12) Confidence 0.37 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.39 Pain Relevance 0.66
Long-term p38 MAPK activation has been shown to increase cardiac hypertrophy, fibrosis and apoptosis suggestive of a deleterious effect on the heart [24-26] and p38 MAPK overexpression has been shown to induce proinflammatory and profibrotic genes [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p38 in heart associated with fibrosis, apoptosis and coronary heart disease
13) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.53 Pain Relevance 0.09
Previous studies have indicated an increase in cardiac fibrosis in response to p38 MAPK overexpression and shown that adenoviral p38-injection into the heart increased CTGF mRNA expression [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p38 in heart associated with fibrosis and cardiovascular disorder under development
14) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.23 Pain Relevance 0.17
Previous studies have indicated an increase in cardiac fibrosis in response to p38 MAPK overexpression and shown that adenoviral p38-injection into the heart increased CTGF mRNA expression [27].
Positive_regulation (increased) of Gene_expression (expression) of p38-injection in heart associated with fibrosis and cardiovascular disorder under development
15) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.25 Pain Relevance 0.17
Our results showed that PTX injection induced activation of microglia and a significant increase in P-p38 MAPK expression in the spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of p38 in spinal cord associated with spinal cord
16) Confidence 0.35 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409222 Disease Relevance 0.45 Pain Relevance 1.22
In contrast to the expression of p-p38, p-ERK1/2 was induced exclusively in neurons.
Positive_regulation (induced) of Gene_expression (expression) of p38 in neurons
17) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 1.04 Pain Relevance 0.76
The immunohistochemical expression of cellular markers of neuronal damage (activating transcription factor 3) or activation (phosphorylated p38 mitogen-activated kinase, NF-kappa B p65) in dorsal root ganglia (DRG) tended to increase with both cytokine injections.
Positive_regulation (increase) of Gene_expression (expression) of p38 in dorsal root ganglia associated with cytokine
18) Confidence 0.32 Published 2005 Journal Pain Section Abstract Doc Link 15964142 Disease Relevance 0.78 Pain Relevance 0.74
Repeated morphine exposure (10-20 microm) for 6 days increased the number of neurons expressing phosphorylated (p) mitogen-activated protein (MAP) kinases, including the extracellular signal-regulated kinase (pERK), c-jun N-terminal kinase (pJNK) and P38 (pP38 MAPK).
Positive_regulation (increased) of Gene_expression (expressing) of P38 in neurons associated with morphine
19) Confidence 0.31 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683901 Disease Relevance 0.85 Pain Relevance 1.62
We have shown that this tolerance leads to alterations in cytokine production, macrophage NF-kappaB activation and p38 MAP-kinase activity.
Positive_regulation (activation) of Gene_expression (production) of p38 MAP-kinase in macrophage associated with tolerance and cytokine
20) Confidence 0.29 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 0.67 Pain Relevance 0.51

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