INT99070

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 8
Speculated 7
Reported most in Body
Documents 147
Total Number 168
Disease Relevance 103.99
Pain Relevance 79.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
neurons 20
microglia 16
spinal cord 12
spinal 11
heart 5
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1760 100.00 Very High Very High Very High
cytokine 712 100.00 Very High Very High Very High
Pain 686 100.00 Very High Very High Very High
Dopamine 341 100.00 Very High Very High Very High
dorsal root ganglion 241 100.00 Very High Very High Very High
spinal dorsal horn 237 100.00 Very High Very High Very High
Osteoarthritis 150 100.00 Very High Very High Very High
fibrosis 100 100.00 Very High Very High Very High
metalloproteinase 94 100.00 Very High Very High Very High
Kinase C 52 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1960 100.00 Very High Very High Very High
Pain 1133 100.00 Very High Very High Very High
Nervous System Injury 935 100.00 Very High Very High Very High
Nociception 712 100.00 Very High Very High Very High
Apoptosis 446 100.00 Very High Very High Very High
Ganglion Cysts 414 100.00 Very High Very High Very High
Osteoarthritis 211 100.00 Very High Very High Very High
Fibrosis 82 100.00 Very High Very High Very High
Coronary Heart Disease 60 100.00 Very High Very High Very High
Repression 18 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Gene_expression (expression) of p38 in spinal
1) Confidence 0.78 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Gene_expression (expression) of p38 in spinal
2) Confidence 0.78 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVE: To investigate the expression of activated p38 mitogen-activated protein kinases (p38 MAP kinase; p38) in the spinal cord and to determine the effect of intrathecal administration of a specific p38 inhibitor on pain in a lumbar disc herniation model and on motor function and hypoalgesia in a spinal canal stenosis (SCS) model.
Spec (investigate) Gene_expression (expression) of p38 in spinal
3) Confidence 0.78 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.10 Pain Relevance 0
Phosphorylation of ERK significantly increased but there were no significant effects on cortical expression of ERK, Jun and p-38.
Gene_expression (expression) of p-38
4) Confidence 0.75 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.68 Pain Relevance 0.11
Tissue samples were processed from the entire AAR of left ventricle for the determination of p38 MAPK protein expression (5 hearts/group).
Gene_expression (expression) of p38 in hearts
5) Confidence 0.74 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17531118 Disease Relevance 0.16 Pain Relevance 0
Double staining studies with NeuN also showed a limited number of neurons expressing P-p38 that were confined to lamina II (see Figure 1F–1H and 1J).


Gene_expression (expressing) of p38 in lamina
6) Confidence 0.74 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.45 Pain Relevance 0.43
In addition, the effect of tonabersat prior to chemical stimulation on gap junction activity and expression of connexins and active p38 was investigated.
Gene_expression (expression) of p38
7) Confidence 0.72 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0.07 Pain Relevance 0
The change in gap junction activity was accompanied by increased expression of connexin 26 and active p38 levels in both neurons and satellite glia in V1 and V2 regions.
Gene_expression (levels) of p38 in neurons
8) Confidence 0.72 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
The change in gap junction activity was accompanied by increased expression of connexin 26 and active p38 levels in both neurons and satellite glia in V1 and V2 regions.
Gene_expression (expression) of p38 in neurons
9) Confidence 0.72 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
RESULTS: A significant increase in number of p-p38 immunoreactive cells was observed in the ipsilateral L4-5 spinal dorsal horn from 1 h to 3 days after the incision. p-p38 was found predominantly in microglia.
Gene_expression (found) of p38 in spinal
10) Confidence 0.67 Published 2009 Journal Anesthesiology Section Body Doc Link 19104183 Disease Relevance 0.14 Pain Relevance 0
These observations suggest that p38alpha kinase inhibition may be an effective therapeutic strategy to manage orthopaedic-related pain.
Neg (inhibition) Gene_expression (inhibition) of p38 associated with pain
11) Confidence 0.65 Published 2009 Journal Pain Section Abstract Doc Link 19167815 Disease Relevance 0.73 Pain Relevance 0.86
Proinflammatory cytokine production via p38 MAPK appears to be dependent on tumor necrosis factor-alpha (TNF-?)
Gene_expression (production) of p38 associated with necrosis, cancer and cytokine
12) Confidence 0.64 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.42 Pain Relevance 1.05
Other molecules are known to influence p38 MAPK function in an arthritic state, including map kinase family members (such as ERK1/2) and NF?
Gene_expression (function) of p38 associated with arthritis
13) Confidence 0.64 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.30 Pain Relevance 0.56
As shown in Figure 1A, P-p38 levels increased in individual rats between days 8 and 17 after immunization.
Gene_expression (levels) of p38 associated with immunization
14) Confidence 0.64 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.28 Pain Relevance 0.16
is responsible for p38 activation, CFA-immunized rats administered either IT vehicle or etanercept on days 7 and 10 were sacrificed on day 11; immunostaining and Western blot analysis on these animals showed that etanercept decreased P-p38 expression, suggesting that TNF?
Gene_expression (expression) of p38 associated with etanercept and intrathecal
15) Confidence 0.64 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.37 Pain Relevance 0.58
Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and ?
Neg (inhibition) Gene_expression (inhibition) of p38 in spinal
16) Confidence 0.64 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1560929 Disease Relevance 1.16 Pain Relevance 0.91
Phosphorylated p38 MAPK was found in microglia and neurons of the RVM.
Gene_expression (found) of p38 in microglia associated with rostroventromedial medulla
17) Confidence 0.62 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19614984 Disease Relevance 0.96 Pain Relevance 1.40
Pretreatment with tonabersat inhibited gap junction communication between neurons and satellite glia and blocked the increase in connexin 26 and active p38 levels in response to injection of both tumor necrosis factor-alpha (V2) and capsaicin (V1).
Gene_expression (levels) of p38 in neurons
18) Confidence 0.62 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
 ; OA: osteoarthritis; p38: p38 mitogen activated kinase; PBMCs: peripheral blood mononuclear cells.


Gene_expression (osteoarthritis) of p38 in mononuclear cells associated with osteoarthritis
19) Confidence 0.61 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 1.71 Pain Relevance 1.20
 ; OA: osteoarthritis; p38: p38 mitogen activated kinase; PBMCs: peripheral blood mononuclear cells.


Gene_expression (osteoarthritis) of p38 in mononuclear cells associated with osteoarthritis
20) Confidence 0.61 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 1.71 Pain Relevance 1.20

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